MicroRNA expression profile is altered in the upper airway skeletal muscle tissue of patients with obstructive sleep apnea-hypopnea syndrome

Hou, Jin; Zhao, Lei; Yan, Jing; Ren, Xiaoyong; Zhu, Kangshun; Gao, Tianxi; Du, Xiaoying; Luo, Huanan; Li, Zhihui; Xu, Min

doi:10.1177/0300060519858900

Cited by 11 publications

(11 citation statements)

References 51 publications

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“…miR-101-3p was also downregulated and was previously reported to exhibit similar pattern in neuromyelitis optica (52) and familial dysautonomia patients (53). Moreover, miR-101-3p was also found to be downregulated in the upper airway skeletal muscles of patients suffering from obstructive sleep apnea-hypopnea syndrome (54).…”

Section: Discussionsupporting

confidence: 63%

miRNome profiling in Duchenne muscular dystrophy; identification of asymptomatic and manifesting female carriers

et al. 2021

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Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disorder that occurs due to inactivating mutations in DMD gene, leading to muscular dystrophy. Prediction of pathological complications of DMD and the identification of female carriers are important research points that aim to reduce disease burden. Herein, we describe a case of a late DMD patient and his immediate female family members, who all carry same DMD mutation and exhibited varied degrees of symptoms. In our study, we sequenced the whole miRNome in leukocytes and plasma of the family members and results were validated using Real-Time PCR. Our results highlighted the role of miR-409-3p, miR-424-5p, miR-144-3p as microRNAs that show correlation with the extent of severity of muscular weakness and can be used for detection of asymptomatic carriers. Cellular and circulating levels of miR-494-3p had showed significant increase in symptomatic carriers, which may indicate significant roles played by this miRNA in the onset of muscular weakness. Interestingly, circulating levels of miR-206 and miR-410-3p were significantly increased only in the severely symptomatic carrier. In conclusion, our study highlighted several miRNA species, which could be used in predicting the onset of muscle and/or neurological complications in DMD carriers.

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Section: Discussionsupporting

confidence: 63%

miRNome profiling in Duchenne muscular dystrophy; identification of asymptomatic and manifesting female carriers

et al. 2021

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“…Based on the normalization counts, the significantly differentially expressed miRNAs in three stages were determined by their fold change. Based on a power analysis using the IDEG6 ( Romualdi et al, 2003 ), we determined that our design had over 99% power to detect differentially expressed miRNAs (DEMs) at | log2(FC) | > = 1 and FDR < = 0.01 ( Hou et al, 2019 ). We then screened for DEMs in the 30 d vs. 60 d and 60 d vs. 90 d pairwise comparisons.…”

Section: Methodsmentioning

confidence: 99%

RNA sequencing-based identification of microRNAs in the antler cartilage of Gansu red deer (Cervus elaphus kansuensis)

Chen

Zhang

et al. 2022

PeerJ

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Background The velvet antler is a complex mammalian bone organ with unique biological characteristics, such as regeneration. The rapid growth stage (RGS) is a special period in the regeneration process of velvet antler. Methods To elucidate the functions of microRNAs (miRNAs) at the RGS of antler development in Gansu red deer (Cervus elaphus kansuensis), we used RNA sequencing (RNA-seq) to analyze miRNA expression profiles in cartilage tissues of deer antler tips at three different growth stages. Results The RNA-seq results revealed 1,073 known and 204 novel miRNAs, including 1,207, 1,242, and 1,204 from 30-, 60-, and 90-d antler cartilage tissues, respectively. To identify key miRNAs controlling rapid antler growth, we predicted target genes of screened 25 differentially expressed miRNAs (DEMs) and specifically expressed miRNAs (SEMs) in 60 d and annotated their functions. The KEGG results revealed that target genes of 25 DEMs and 30 SEMs were highly classified in the “Metabolic pathways”, “Pathways in cancer”, “Proteoglycans in cancer” and “PI3K-Akt signaling pathway”. In addition, a novel miRNA (CM008039.1_315920), highly enriched in “NF-kappa B signaling pathway”, may need further study. Conclusions The miRNAs identified in our study are potentially important in rapid antler growth. Our findings provide new insights to help elucidate the miRNA-mediated regulatory mechanisms involved during velvet antler development in C. elaphus kansuensis.

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“…In addition, a study of the miRNA profiles of OSA in samples of upper airway skeletal muscle was conducted [43]. From the 370 miRNAs identified in the screening phase, hsa-let-7 family miRNAs, hsa-miR-34a-5p, hsa-miR-92a-3p, and hsa-miR-101-3p were downregulated in OSA patients.…”

Section: Micrornas In Obstructive Sleep Apnoeamentioning

confidence: 99%

Micro-RNA in obstructive sleep apnoea: biomarker of cardiovascular outcome?

Zapater

Barbé

Sánchez‐de‐la‐Torre

2022

Current Opinion in Pulmonary Medicine

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Purpose of reviewObstructive sleep apnoea (OSA) is a global health problem with important cardiovascular consequences. Risk assessment tools are essential in OSA to identify patients at increased risk of cardiovascular disease and to achieve a cost-effective clinical management of the disease in the era of precision medicine. The objective is to provide an updated perspective on the role of microRNAs (miRNAs) in OSA as a biomarker of cardiovascular risk.Recent findingsSpecific miRNAs have already been associated with patients with OSA and specific cardiovascular diseases such as hypertension, myocardial infarction or endothelial dysfunction. Numerous studies have addressed the use of miRNAs to identify the cardiovascular risk associated with OSA, both in patients and in animals with in vivo hypoxia models. Thus, these studies identified profiles of differentially expressed miRNAs in patients with OSA. In addition, the in vitro studies suggest that therapies with miRNA inhibitors that could help reduce cardiovascular risk. Therefore, this review highlights the primary approaches of the potential of miRNAs as biomarkers at the prognostic, diagnostic and therapeutic strategy levels.SummaryGiven the heterogeneity of OSA and its cardiovascular consequences, miRNAs have emerged as powerful biomarkers that can help improve the clinical management of OSA and its cardiovascular risk.

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MicroRNA expression profile is altered in the upper airway skeletal muscle tissue of patients with obstructive sleep apnea-hypopnea syndrome

Cited by 11 publications

References 51 publications

miRNome profiling in Duchenne muscular dystrophy; identification of asymptomatic and manifesting female carriers

miRNome profiling in Duchenne muscular dystrophy; identification of asymptomatic and manifesting female carriers

RNA sequencing-based identification of microRNAs in the antler cartilage of Gansu red deer (Cervus elaphus kansuensis)

Micro-RNA in obstructive sleep apnoea: biomarker of cardiovascular outcome?

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