2020
DOI: 10.1186/s43168-020-00021-2
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MicroRNA genetic signature in non-small cell lung cancer (NSCLC) Egyptian patients

Abstract: Background: Cancer development is associated with deregulated microRNA (miRNA) in body fluids including serum, plasma, and bronchoalveolar lavage (BAL). Early diagnosis and early treatment of lung cancer improve survival and response to treatment. So, finding an easy detectable biomarker is crucially important to improve the disease outcome. So, we analyzed the differential expression of miRNA using microarray both in serum and BAL of 37 non-small cell lung cancer (NSCLC) patients and 30 healthy control subjec… Show more

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Cited by 3 publications
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“…Furthermore, it is crucial to acknowledge that miRNAs, which target proto-oncogenes and tumor suppressor genes, undergo regulation within cancer cells based on the specific context imposed by the ongoing process of carcinogenesis. This implies that the expression patterns of miRNAs in tumor tissue may carry a distinct connotation compared to the profiles observed in the cell-free circulating miRNAs we analyzed from blood serum [78,79]. Additionally, different subtypes of NSCLC, such as adenocarcinoma or squamous cell carcinoma, may also exhibit distinct miRNA expression patterns [78,79].…”
Section: Discussionmentioning
confidence: 95%
See 3 more Smart Citations
“…Furthermore, it is crucial to acknowledge that miRNAs, which target proto-oncogenes and tumor suppressor genes, undergo regulation within cancer cells based on the specific context imposed by the ongoing process of carcinogenesis. This implies that the expression patterns of miRNAs in tumor tissue may carry a distinct connotation compared to the profiles observed in the cell-free circulating miRNAs we analyzed from blood serum [78,79]. Additionally, different subtypes of NSCLC, such as adenocarcinoma or squamous cell carcinoma, may also exhibit distinct miRNA expression patterns [78,79].…”
Section: Discussionmentioning
confidence: 95%
“…This implies that the expression patterns of miRNAs in tumor tissue may carry a distinct connotation compared to the profiles observed in the cell-free circulating miRNAs we analyzed from blood serum [78,79]. Additionally, different subtypes of NSCLC, such as adenocarcinoma or squamous cell carcinoma, may also exhibit distinct miRNA expression patterns [78,79]. Second, different detection methods and platforms, including microarray, qRT-PCR, and sequencing, can affect the sensitivity, specificity, and reproducibility of miRNA measurement [78,79].…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations