MicroRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors

Lavaud, Mélanie; Georges, Steven; Ory, Benjamin

doi:10.1016/b978-0-12-821666-8.00063-3

Cited by 1 publication

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References 70 publications

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“…These activities were related to YAP activation. Several recent publications showed the role played by specific miRNA in controlling stemness in osteosarcoma, including miR29b and its target Spin1 [ 82 ] , miR34a [ 83 ] and the DNMT1/miR34a/Bcl2 axis [ 84 , 85 ] , TNF-α-miR155 signaling [ 86 ] , miR335 and its target POUF5 [ 87 ] , miR429 and its target Sox2 [ 88 ] , and the TGF-β/miR499a/SHKBP1 89 axis [ 89 , 90 ] . Very recently, leukemia inhibitory factor (LIF) was shown to belong to the IL-6 family of cytokines, similarly activating STAT-3, and was recently revealed as a super-enhancer-controlled regulator of CSC properties, confirming the role of STAT-3 transcription factor in the functional regulation of CSCs in osteosarcoma [ 91 ] .…”

Section: Molecular Regulation Of Cancer Stem-like Cells In Osteosarcomamentioning

confidence: 99%

Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma

Jubelin¹,

Muñoz-García²,

Cochonneau³

et al. 2022

CDR

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Sarcomas are a large family of cancers originating in the mesenchyme. Composed of more than 100 histological subtypes, soft tissue and bone sarcomas remain clinically challenging, particularly in children and adolescents in whom sarcomas are the second most common malignant entities. Osteosarcoma is the main primary bone tumor in adolescents and young adults and is characterized by a high propensity to induce distant metastatic foci and become multi-drug resistant. The innate and acquired resistance of osteosarcoma can be explained by high histological heterogeneity and genetic/molecular diversity. In the last decade, the notion of cancer stem-like cells (CSCs) has emerged. This subset of cancer cells has been linked to drug resistance properties, recurrence of the disease, and therapeutic failure. Although CSCs remain controversial, many elements are in favor of them playing a role in the development of the drug resistance profile. The present review gives a brief overview of the most recent biological evidence of the presence of CSCs in osteosarcomas and their role in the drug resistance profile of these rare oncological entities. Their use as promising therapeutic targets is discussed.

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Section: Molecular Regulation Of Cancer Stem-like Cells In Osteosarcomamentioning

confidence: 99%

Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma

Jubelin¹,

Muñoz-García²,

Cochonneau³

et al. 2022

CDR

View full text Add to dashboard Cite

show abstract

MicroRNA implication in therapeutic resistance and metastatic dissemination of bone-associated tumors

Cited by 1 publication

References 70 publications

Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma

Biological evidence of cancer stem-like cells and recurrent disease in osteosarcoma

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