MicroRNA let-7 and viral infections: focus on mechanisms of action

Letafati, Arash; Najafi, Sajad; Mottahedi, Mehran; Karimzadeh, Mohammad Reza; Shahini, Ali; Garousi, Setareh; Abbasi-Kolli, Mohammad; Nahand, Javid Sadri; Zadeh, Seyed Saeed Tamehri; Hamblin, Michael R.; Rahimian, Neda; Taghizadieh, Mohammad; Mirzaei, Hamed

doi:10.1186/s11658-022-00317-9

Cited by 77 publications

(45 citation statements)

References 335 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MicroRNAs (miRNAs) are small (20–23 nts) and non-coding RNA molecules that negatively influence gene expression by binding to mRNAs and thereby promoting degradation of the target mRNA or blocking its translation into protein ( 19 , 68 – 79 ).…”

Section: Biogenesis and Function Of Micrornas And Their Roles In Prog...mentioning

confidence: 99%

“…Recent studies have demonstrated that numerous miRNAs can strongly affect the expression of pro- and anti-apoptotic genes, oncogenes, ER stress- and/or necroptosis-related genes ( 20 , 103 ). Aberrations involving miRNAs implicated in apoptosis or necroptosis could also impact physiological conditions and promote disease, including carcinogenesis and infection diseases ( 19 , 104 – 106 ). Numerous studies have demonstrated that miRNAs usually target multiple mRNAs and they could act as so-called apopto-miRs, oncomiR or tumor suppressor miRNAs in different cancers.…”

Section: Biogenesis and Function Of Micrornas And Their Roles In Prog...mentioning

confidence: 99%

See 1 more Smart Citation

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

Self Cite

View full text Add to dashboard Cite

Oral cancer remains a major public concern with considerable socioeconomic impact in the world. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for oral cancer remained undesirable, and the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Noncoding RNAs (ncRNAs) include transfer RNAs (tRNAs), as well as small RNAs such as microRNAs, and the long ncRNAs such as HOTAIR are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including cancer cell development. Cell death, such as apoptosis, necrosis, and autophagy, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between ncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of oral cancer can be controlled by increasing or decreasing the expression of ncRNAs, a method which confers broad prospects for oral cancer treatment. Therefore, it is urgent for us to understand the influence of ncRNAs on the development of different modes of oral tumor death, and to evaluate whether ncRNAs have the potential to be used as biological targets for inducing cell death and recurrence of chemotherapy. The purpose of this review is to describe the impact of ncRNAs on cell apoptosis and autophagy in oral cancer in order to explore potential targets for oral cancer therapy.

show abstract

Section: Biogenesis and Function Of Micrornas And Their Roles In Prog...mentioning

confidence: 99%

Section: Biogenesis and Function Of Micrornas And Their Roles In Prog...mentioning

confidence: 99%

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…An important aspect of virus–host relation during SARS-CoV-2 infection and COVID-19 course is the role of miRNAs. This issue has been a subject of recent reviews [ 132 , 133 ]. One of the first known major modes of action of the virus on the host cell is sequestering of the host miRNAs [ 134 ].…”

Section: Final Remarksmentioning

confidence: 99%

COVID-19 therapies: do we see substantial progress?

et al. 2022

View full text Add to dashboard Cite

The appearance of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its spread all over the world is the cause of the coronavirus disease 2019 (COVID-19) pandemic, which has recently resulted in almost 400 million confirmed cases and 6 million deaths, not to mention unknown long-term or persistent side effects in convalescent individuals. In this short review, we discuss approaches to treat COVID-19 that are based on current knowledge of the mechanisms of viral cell receptor recognition, virus–host membrane fusion, and inhibition of viral RNA and viral assembly. Despite enormous progress in antiviral therapy and prevention, new effective therapies are still in great demand.

show abstract

“…miRNAs are a major class of conserved short noncoding RNAs with crucial biological functions in the regulation of a third of the whole genome at the posttranslational level [ 68 ]. miRNAs exert their roles by increasing messenger RNA degradation or by blocking messenger RNA translation [ 69 ].…”

Section: Introductionmentioning

confidence: 99%

Protective effects of dexmedetomidine in vital organ injury: crucial roles of autophagy

Zhao

Wu²,

Lin

et al. 2022

Cell Mol Biol Lett

View full text Add to dashboard Cite

Vital organ injury is one of the leading causes of global deaths. Accumulating studies have demonstrated that dexmedetomidine (DEX) has an outstanding protective effect on multiple organs for its antiinflammatory and antiapoptotic properties, while the underlying molecular mechanism is not clearly understood. Autophagy, an adaptive catabolic process, has been found to play a crucial role in the organ-protective effects of DEX. Herein, we present a first attempt to summarize all the evidence on the proposed roles of autophagy in the action of DEX protecting against vital organ injuries via a comprehensive review. We found that most of the relevant studies (17/24, 71%) demonstrated that the modulation of autophagy was inhibited under the treatment of DEX on vital organ injuries (e.g. brain, heart, kidney, and lung), but several studies suggested that the level of autophagy was dramatically increased after administration of DEX. Albeit not fully elucidated, the underlying mechanisms governing the roles of autophagy involve the antiapoptotic properties, inhibiting inflammatory response, removing damaged mitochondria, and reducing oxidative stress, which might be facilitated by the interaction with multiple associated genes (i.e., hypoxia inducible factor-1α, p62, caspase-3, heat shock 70 kDa protein, and microRNAs) and signaling cascades (i.e., mammalian target of rapamycin, nuclear factor-kappa B, and c-Jun N-terminal kinases pathway). The authors conclude that DEX hints at a promising strategy in the management of vital organ injuries, while autophagy is crucially involved in the protective effect of DEX.

show abstract

MicroRNA let-7 and viral infections: focus on mechanisms of action

Cited by 77 publications

References 335 publications

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

COVID-19 therapies: do we see substantial progress?

Protective effects of dexmedetomidine in vital organ injury: crucial roles of autophagy

Contact Info

Product

Resources

About