MicroRNA levels in hemodialysis patients following resistance training: Associations with functional performance, inflammatory profile, sestrins-2, and nitric oxide

Corrêa, Hugo de Luca; Neves, Rodrigo Vanerson Passos; Deus, Lysleine Alves; Reis, Andrea Lucena; Raab, Artur Temizio Oppelt; Rodrigues-Silva, Paolo Lucas; Barbosa, João Alexandre Ribeiro Gonçalves; Araújo, Thaís Branquinho de; Silva, Marcelo Guido Silveira da; Ferreira, Carlos Ernesto Santos; Simões, Herbert Gustavo; Prestes, Jonato; Franco, Octávio Luiz; Andrade, Rosângela Vieira de; Rosa, Thiago Santos

doi:10.1016/j.exger.2022.111761

Cited by 4 publications

(6 citation statements)

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“…Functional performance was evaluated by the Timed Up-and-Go (TUG) test and six-minute walking test (6MWT). Procedures were fully explained before the assessment, followed by a familiarization attempt as described elsewhere (19).…”

Section: Handgrip Strength and Functional Performancementioning

confidence: 99%

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Phosphate and IL-10 concentration as predictors of long-covid in hemodialysis patients: A Brazilian study

et al. 2022

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BackgroundThe global burden of persistent COVID-19 in hemodialysis (HD) patients is a worrisome scenario worth of investigation for the critical care of chronic kidney disease (CKD). We performed an exploratory post-hoc study from the trial U1111-1237-8231 with two specific aims: i) to investigate the prevalence of COVID-19 infection and long COVID symptoms from our Cohort of 178 Brazilians HD patients. ii) to identify whether baseline characteristics should predict long COVID in this sample.Methods247 community-dwelling older (>60 years) patients (Men and women) undergoing HD (glomerular filtration rate < 15 mL/min/1.73m2) with arteriovenous fistula volunteered for this study. All patients presented hypertension and diabetes. Patients were divided in two groups: without long-COVID and with long-COVID. Body composition, handgrip strength, functional performance, iron metabolism, phosphate, and inflammatory profile were assessed. Patients were screened for 11-months after COVID-19 infection. Results were considered significant at P < 0.05.ResultsWe found that more than 85% of the COVID-19 infected patients presented a severe condition during the infection. In our sample, the mortality rate over 11-month follow was relatively low (8.4%) when compared to worldwide (approximately 36%). Long COVID was highly prevalent in COVID-19 survivors representing more than 80% of all cases. Phosphate and IL-10 were higher in the long COVID group, but only phosphate higher than 5.35 mg/dL appears to present an increased prevalence of long COVID, dyspnea, and fatigue.ConclusionThere was a high prevalence of COVID-19 infection and long COVID in HD patients from the Brazilian trial ‘U1111-1237-8231’. HD clinics should be aware with phosphate range in HD patients as a possible target for adverse post-COVID events.

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Section: Handgrip Strength and Functional Performancementioning

confidence: 99%

“…Coronavirus disease 2019 (COVID- 19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has impacted worldwide public health (1,2). More than 6 million deaths were registered by May 2022, being more evident in Europe and Americas (https://covid19.who.int/; assessed 30 May 2022).…”

Section: Introductionmentioning

confidence: 99%

Phosphate and IL-10 concentration as predictors of long-covid in hemodialysis patients: A Brazilian study

et al. 2022

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“…Our findings regarding the predictive roles of baseline miRNA-206 and miRNA-23a expression on the change of muscle function in HP fully align with existing evidence (Van Craenenbroeck et al, 2015;Robinson et al, 2020;de Luca Corrêa et al, 2022;Wang et al, 2023). We found that the baseline expression level of miRNA-206 among CKD5-HD patients highly predicted a change in muscle function after IDE.…”

Section: Impact Of a Patient´s Age Sex And Expression Of Microribonuc...supporting

confidence: 87%

“…We also found that the baseline expression of miRNAs could predict the functional response to IDE, but that more detailed evidence is lacking. The roles of MiRNA expression profiles in functional adaptation to resistance training are well described in healthy and chronic disease populations, but limited evidence exists on the effectiveness and individualisation of IDE (Davidsen et al, 2011;Kirby & McCarthy, 2013;Van Craenenbroeck et al, 2015;Ogasawara et al, 2016;Hagstrom & Denham, 2018;Domańska-Senderowska et al, 2019;Navaratnarajah et al, 2020;Robinson et al, 2020;Da Silva et al, 2021;Bell et al, 2022;de Luca Corrêa et al, 2022;Krammer et al, 2022;Telles et al, 2022;Widmann et al, 2022;Grieb et al, 2023;Kotewitsch et al, 2023;Mastrototaro & Roden, 2023;Wang et al, 2023;Xhuti et al, 2023). This implies that future studies on the roles of miRNA expression profiles in physiological response to different settings of physical activity might significantly increase effectiveness on muscle function, partially in a group of lowresponding patients.…”

Section: Implications For Future Researchmentioning

confidence: 99%

Intradialytic exercise in haemodialysis patients: applicability and effects on muscle function

Zelko

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“…NO bioavailability (assessed by NO 2 − levels) were analysed as previously described by Correa et al 20 ADMA concentration was determined by ELISA, the intra‐ and inter‐assay CV were ≤8% and ≤12%, respectively (Human ADMA ELISA Kit, MyBioSource, San Diego, USA).…”

Section: Methodsmentioning

confidence: 99%

Exploring the impact of short daily haemodialysis on muscle strength and bone health in end‐stage kidney disease patients

Tavares,

de Luca Corrêa,

Wilund

et al. 2024

J cachexia sarcopenia muscle

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BackgroundShort‐daily haemodialysis (SDH) has been strongly recommended over conventional haemodialysis (CHD) for end‐stage kidney disease patients, though few studies have directly compared the effects of these two haemodialysis (HD) modalities on clinical variables related to patient's health.MethodsWe conducted a cross‐sectional study in individuals undergoing HD, comparing epidemiological, clinical, metabolic, inflammatory, anthropometric, bone health/metabolism, and skeletal muscle function according to dialysis modality. One‐hundred seventy‐eight patients (20.8% females, 62 ± 2.5 years old), were analysed in this study, 86 (48%) of whom were undergoing CHD versus 92 (51%) who were undergoing SDH.ResultsSDH patients had significantly higher serum albumin levels (3.93 vs. 3.66 g/dL, P < 0.0001) and higher Kt/v (2.6 vs. 2.38, P < 0.0001). SDH group presented a significantly lower number of erythropoietin‐stimulating agents compared with CHD group (percentage: 53.3 vs. 83.7%, P < 0.0001) and had lower levels of serum phosphate (4.9 vs. 5.3 mg/dL, P = 0.004) and parathyroid hormone (PTH) (398.4 vs. 480.4 pg/mL, P < 0.001) compared with CHD patients. In terms of bone health and metabolism, SDH patients had significantly higher total BMD, femur BMD, lumbar BMD, and femoral neck BMD compared with CHD patients (all P < 0.05). SDH patients also had lower anti‐osteogenic and inflammatory biomarkers, including FGF23, sclerostin, TNF, IL‐18, IL‐17a, and C‐reactive peptide (all P < 0.05). CHD modality was demonstrated to be a risk factor for low BMD (odds ratio: 4.02; 95% CI: 1.59–10.2, P = 0.003). In terms of skeletal muscle function, SDH patients had significantly higher 6‐minute walking test (444.6 vs. 424.9 m, P = 0.04) and higher fat‐free mass (52.3 vs. 51.68 kg, P = 0.02) compared with CHD patients. Higher fat‐free mass and handgrip strength were associated with a 34% and 23% lower risk of low BMD, respectively. SDH patients had lower levels of the uremic toxin asymmetric dimethyl‐ l‐arginine (ADMA) (1.8 vs. 2.07 μM, P = 0.002) and fasting blood glucose (132.6 vs. 141.7 mg/dL, P < 0.02) than CHD group. SDH patients also displayed higher levels of haemoglobin when compared with CHD group (11.9 vs. 10.2 g/dL, P < 0.0001).ConclusionsThe present study improves our understanding of the relationship between dialysis modality and clinical variables that may influence HD patient's health. Grip strength and lean mass were positively correlated with bone mineral density in HD patients regardless of dialysis modality. SDH was associated with better bone mineral density, inflammatory profile, and skeletal muscle function when compared with CHD patients. These findings provide more evidence of the clinical benefits of SDH that should be explored in greater detail.

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MicroRNA levels in hemodialysis patients following resistance training: Associations with functional performance, inflammatory profile, sestrins-2, and nitric oxide

Cited by 4 publications

References 40 publications

Phosphate and IL-10 concentration as predictors of long-covid in hemodialysis patients: A Brazilian study

Phosphate and IL-10 concentration as predictors of long-covid in hemodialysis patients: A Brazilian study

Intradialytic exercise in haemodialysis patients: applicability and effects on muscle function

Exploring the impact of short daily haemodialysis on muscle strength and bone health in end‐stage kidney disease patients

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