MicroRNA-mediated immune modulation as a therapeutic strategy in host-implant integration

Ong, Siew-Min; Biswas, Subhra K.; Wong, Sek-Man

doi:10.1016/j.addr.2015.05.013

Cited by 19 publications

(11 citation statements)

References 228 publications

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“…The design of biomaterials to specifically modulate macrophage behavior has emerged as a promising strategy in regenerative medicine and tissue engineering (see refs. ), including utilization of controlled release systems or microRNA‐focused techniques . Here we highlight key studies that have modified biomaterial surfaces and structures to control both macrophage and fibroblast behavior along with combination strategies that include delivery of soluble factors through the use of coatings, films, electrospinning, liposomes, and polymeric particles.…”

Section: Strategies For Modulating Macrophage and Fibroblast Behaviormentioning

confidence: 99%

Macrophage and Fibroblast Interactions in Biomaterial‐Mediated Fibrosis

Witherel

Abebayehu

Barker

et al. 2019

Adv Healthcare Materials

272

201

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Biomaterial‐mediated inflammation and fibrosis remain a prominent challenge in designing materials to support tissue repair and regeneration. Despite the many biomaterial technologies that have been designed to evade or suppress inflammation (i.e., delivery of anti‐inflammatory drugs, hydrophobic coatings, etc.), many materials are still subject to a foreign body response, resulting in encapsulation of dense, scar‐like extracellular matrix. The primary cells involved in biomaterial‐mediated fibrosis are macrophages, which modulate inflammation, and fibroblasts, which primarily lay down new extracellular matrix. While macrophages and fibroblasts are implicated in driving biomaterial‐mediated fibrosis, the signaling pathways and spatiotemporal crosstalk between these cell types remain loosely defined. In this review, the role of M1 and M2 macrophages (and soluble cues) involved in the fibrous encapsulation of biomaterials in vivo is investigated, with additional focus on fibroblast and macrophage crosstalk in vitro along with in vitro models to study the foreign body response. Lastly, several strategies that have been used to specifically modulate macrophage and fibroblast behavior in vitro and in vivo to control biomaterial‐mediated fibrosis are highlighted.

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Section: Strategies For Modulating Macrophage and Fibroblast Behaviormentioning

confidence: 99%

Macrophage and Fibroblast Interactions in Biomaterial‐Mediated Fibrosis

Witherel

Abebayehu

Barker

et al. 2019

Adv Healthcare Materials

272

201

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“…Small interfering RNA (siRNA)and microRNA (miRNA) platforms have been proposed to regulate the immune response to implants, promote wound healing, and improve host-implant integration [84]. In particular, a limited number of studies have explored the controlled release of nucleic acids (e.g., genes, miRNAs, and siRNAs) to alleviate inflammation or promote healing by targeting macrophage-related functions in tissue engineering applications [84].…”

Section: Delivering Molecules To Control Macrophage Polarizationmentioning

confidence: 99%

“…In particular, a limited number of studies have explored the controlled release of nucleic acids (e.g., genes, miRNAs, and siRNAs) to alleviate inflammation or promote healing by targeting macrophage-related functions in tissue engineering applications [84]. However, in other inflammatory scenarios, such as inflammatory diseases, autoimmune diseases, and cancer, the delivery of nucleic acids has been frequently tested as a means of controlling inflammation or promoting healing.…”

Section: Delivering Molecules To Control Macrophage Polarizationmentioning

confidence: 99%

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

Álvarez

Liu

Santiago

et al. 2016

Journal of Controlled Release

201

119

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Macrophages are key players in many physiological scenarios including tissue homeostasis. In response to injury, typically the balance between macrophage sub-populations shifts from an M1 phenotype (pro-inflammatory) to an M2 phenotype (anti-inflammatory). In tissue engineering scenarios, after implantation of any device, it is desirable to exercise control on this M1-M2 progression and to ensure a timely and smooth transition from the inflammatory to the healing stage. In this review, we briefly introduce the current state of knowledge regarding macrophage function and nomenclature. Next, we discuss the use of controlled release strategies to tune the balance between the M1 and M2 phenotypes in the context of tissue engineering applications. We discuss recent literature related to the release of anti-inflammatory molecules (including nucleic acids) and the sequential release of cytokines to promote a timely M1-M2 shift. In addition, we describe the use of macrophages as controlled release agents upon stimulation by physical and/or mechanical cues provided by scaffolds. Moreover, we discuss current and future applications of “smart” implantable scaffolds capable of controlling the cascade of biochemical events related to healing and vascularization. Finally, we provide our opinion on the current challenges and the future research directions to improve our understanding of the M1-M2 macrophage balance and properly exploit it in tissue engineering and regenerative medicine applications.

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“…These aspects might all confer an improved long-term survival to transplanted cells and generated liver organoids and avoid immune reactions with hepatocyte-based bioreactor systems. However, a detailed discussion of immune-modulation by miRNAs is beyond the focus of this review and can be found in this issue [93] and elsewhere [94].…”

Section: Biliary Treementioning

confidence: 99%