microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ

Karbiener, Michael; Fischer, Christoph; Nowitsch, Susanne; Opriessnig, Peter; Papak, Christine; Ailhaud, Gérard; Dani, Christian; Amri, Ez-Zoubir; Scheideler, Marcel

doi:10.1016/j.bbrc.2009.09.098

Cited by 387 publications

(323 citation statements)

References 21 publications

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“…Previous studies have shown that some differentially and abundantly expressed miRNAs (down-regulated miRNAs: ssc-let-7i, ssc-miR-21, ssc-miR-27b-3p and up-regulated miRNAs: ssc-miR-1, ssc-miR-133a-3p, ssc-miR-486) were responsible for regulating adipogenic differentiation [36][37][38][41][42][43]. ssc-miR-1 and ssc-miR133a were found extensively in skeletal muscle tissues while ssc-miR-21, ssc-miR-27b-3p, and the Let-7 family play important roles in adipomuscle and myocardial tissue.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Zhang¹,

Huang²,

Guo³

et al. 2017

Oncotarget

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The domestic pig, an important species in the animal production industry, is also a model system for studying fat deposition and fat-associated diseases in humans. In order to investigate the genetic relationships of the miRNAs that may regulate fat deposition, we performed a genome-wide analysis of miRNAs derived from subcutaneous adipose tissue of Laiwu and Large White pig using RNA-seq. A total of 26,486,906 reads were obtained. Further analysis indicated that 39 known miRNAs and 56 novel miRNAs had significantly differential expression between the two breeds of pigs. Gene Ontology and KEGG pathway analysis revealed that the predicted targets of these differentially expressed miRNAs were involved in several fat-associated pathways, such as the PPAR, MAPK and Wnt signaling pathways. In addition, we found that three miRNAs, ssc-miR-133a-3p, ssc-miR-486 and ssc-miR-1, had an impact on the development of porcine subcutaneous fat through the PPAR signaling pathway. This study provides clues to understand the potential mechanisms of adipogenesis and fat deposition between two different pig breeds. Furthermore, these results may also contribute to the research involving human obesity.

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Section: Discussionmentioning

confidence: 99%

WITHDRAWN: An integrated analysis of microRNAs involved in fat deposition in different pig breeds

Zhang¹,

Huang²,

Guo³

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Similarly, microRNA-21 stalls adipogenesis by inhibiting the TGF-β signaling pathway and microRNA-143 acts in the similar fashion through down-regulating ERK-5 function [54]. The let-7 microRNA inhibits adipogenesis by targeting high-mobility group AT-hook 2 (HMGA-2) [53], whereas microRNA-27 and microRNA-130 function through suppressing peroxisome proliferator activated receptor γ directly [61,62].…”

Section: Micrornas Are Important For Adipose Tissue Functionmentioning

confidence: 99%

MicroRNA Regulated Macrophage Activation in Obesity

Kamanemi¹,

Ying²,

Bazer³

et al. 2013

J Nutr Food Sci

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Obesity and many other metabolic disorders, including type 2 diabetes and atherosclerosis, have conventionally been viewed as lipid storage disorders caused by over nutrition. Research has demonstrated that the obesity associated chronic low-grade tissue inflammation and oxidative stress is crucial factors in the initiation, propagation, and development of these metabolic disorders. Disruption in the normal functioning of the immune system and its interaction with host tissue cells makes it difficult to treat these diseases. Macrophages play critical roles in the development of insulin resistance and tissue inflammation, particularly through a unique shift in polarized activation status from an anti-inflammatory M2 function in lean adipose tissues to proinflammatory M1 activation in adipose tissues of obese individuals. Compelling evidence demonstrated the significance of microRNAs as important regulators in the immune system network. Our recent research has demonstrated that microRNA-223 is a crucial regulator of obesity associated insulin resistance through regulation of macrophage polarization in adipose tissue. This review highlights the importance of various microRNAs and their roles played in the polarization of macrophages which could be targeted for development of new therapeutic strategies to treat obesity associated diseases.

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“…In line with this, several in vitro studies have already revealed distinct miRNAs to steer murine adipocyte differentiation, 6,[10][11][12][13][14][15][16][17] while only a few studies did so for human. [18][19][20][21] We are interested in miRNAs with a regulatory role in adipocyte differentiation and function, particularly in human. In this study, we focused on miR-30c, which is induced during adipocyte differentiation of human multipotent adiposederived stem (hMADS) cells, a unique human model system for adipogenesis.…”

Section: Mir-30c Is Upregulated During Adipocyte Differentiationmentioning

confidence: 99%