MicroRNA MultiTool: A Software for Identifying Modified and Unmodified Human microRNA Using Mass Spectrometry

Cui, Zhonghao; Chiu, Norman H. L.; Wambua, Dickson M.

doi:10.3390/ncrna3010013

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…The current technologies/techniques used for the study of nutrigenetics and nutrigenomics are shown in Table 1. The demand for determining genome, transcriptome, proteome, metabolome and mutation-specific profile characteristics has led to the implementation of several technologies, some of which are simple and inexpensive technologies, such as polymerase chain reaction (PCR)-based methods [7,11,12,13]. The more complex and costly technologies consist of microarray, Sanger sequencing and next generation sequencing (NGS), mass spectrometry (MS), and liquid chromatography coupled with mass spectrometry (LC–MS).…”

Section: Introductionmentioning

confidence: 99%

Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention

et al. 2019

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Regarding cancer as a genetic multi-factorial disease, a number of aspects need to be investigated and analyzed in terms of cancer’s predisposition, development and prognosis. One of these multi-dimensional factors, which has gained increased attention in the oncological field due to its unelucidated role in risk assessment for cancer, is diet. Moreover, as studies advance, a clearer connection between diet and the molecular alteration of patients is becoming identifiable and quantifiable, thereby replacing the old general view associating specific phenotypical changes with the differential intake of nutrients. Respectively, there are two major fields concentrated on the interrelation between genome and diet: nutrigenetics and nutrigenomics. Nutrigenetics studies the effects of nutrition at the gene level, whereas nutrigenomics studies the effect of nutrients on genome and transcriptome patterns. By precisely evaluating the interaction between the genomic profile of patients and their nutrient intake, it is possible to envision a concept of personalized medicine encompassing nutrition and health care. The list of nutrients that could have an inhibitory effect on cancer development is quite extensive, with evidence in the scientific literature. The administration of these nutrients showed significant results in vitro and in vivo regarding cancer inhibition, although more studies regarding administration in effective doses in actual patients need to be done.

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