microRNA profiling for early detection of nonmelanoma skin cancer

Balcı, Şenay; Ayaz, Lokman; Görür, Ayşegül; Yaroğlu, Hatice Yildirim; Akbayir, Serin; Ünal, Nil; Bulut, Bilal; Türsen, Ümit; Tamer, Lülüfer

doi:10.1111/ced.12736

Cited by 35 publications

(28 citation statements)

References 23 publications

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“…Expression of miR-186-5p has only been reported in two studies, one on head & neck squamous cell carcinoma and another on non-melanoma skin cancer [11,15].…”

Section: Discussionmentioning

confidence: 99%

“…Overexpression of miR-186-5p was associated with poor prognosis of patients with head and neck squamous cell carcinoma [15]. In this study, we noted that overexpression of miR-186-5p in colorectal cancer was correlated with distant metastasis and lymphovascular permeation The prognosis of patients with colorectal cancer depends on the TNM pathological staging, which is a collective assessment of cancer invasion, lymph node and distant metastasis [25].…”

Section: Discussionmentioning

confidence: 99%

“…In cancer, miR-186-5p was significantly up regulated in head & neck and skin carcinomas [11,15]. Importantly, circulating plasma miR-186-5p differentiated the patient with head & neck squamous cell carcinoma from healthy individuals with high specificity and sensitivity [11].…”

Section: Introductionmentioning

confidence: 98%

“…They modulate carcinogenesis of colorectal cancer by activating oncogenes and inactivating tumour suppressor genes, or DNA repair genes [1,7]. miR-186-5p, located at 1p31.1, has been reported to have roles in the pathogenesis of cancers, Alzheimer's disease, neuronal disorder and acute myocardial infarction [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor

Islam

Gopalan

Vider

et al. 2017

Experimental Cell Research

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“…Expression of miR-186-5p has only been reported in two studies, one on head & neck squamous cell carcinoma and another on non-melanoma skin cancer [11,15].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor

Islam

Gopalan

Vider

et al. 2017

Experimental Cell Research

View full text Add to dashboard Cite

“…Therefore, analysis of circulating miRNA expression levels can be potentially employed for use in a noninvasive biomarker test for NMSC. Plasma profiling for early detection of NMSC has been explored in one recent study, which showed significant changes in expression of miRNA-19a, miRNA-25, miRNA-30a, miRNA-145, miRNA-186 [108]. While these are interesting findings, extensive validation of the clinical utility of these miRNAs as NMSC biomarkers is required.…”

Section: Rna Markersmentioning

confidence: 99%

Molecular Mechanisms and Biomarkers of Skin Photocarcinogenesis

López¹,

Liu²,

Geskin³

2018

Human Skin Cancers - Pathways, Mechanisms, Targets and Treatments

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Skin cancer is the most commonly diagnosed malignancy in the United States and worldwide. While melanoma is the deadliest form of skin cancer, non-melanoma skin cancers, which include basal cell carcinoma and squamous cell carcinoma, are responsible for significant morbidity in millions of Americans each year. While numerous attempts have been made to reduce skin cancer risk factors related to ultraviolet radiation exposure, skin cancer incidence continues to rise. Improved understanding of the molecular pathways underlying skin cancer pathogenesis has led to the investigation of new approaches to skin cancer prevention. In particular, the search for ultraviolet radiation associated biomarkers of skin cancer has become a rapidly expanding and promising area of research. Advances in genetic sequencing have facilitated the discovery of novel biomarkers, which have the potential to profoundly improve patient care. Here we will review the molecular genetics of skin cancer and analyze the existing literature of proposed biomarkers for potential use in skin cancer diagnosis and prevention.

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Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

Himawan

Vora

Permana

et al. 2022

Adv Healthcare Materials

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Extracellular tissue fluids are interesting biomatrices that have recently attracted scientists' interest. Many significant biomarkers for localized external organ diseases have been isolated from this biofluid. In the diagnostic and disease monitoring context, measuring biochemical entities from the fluids surrounding the diseased tissues may give more important clinical value than measuring them at a systemic level. Despite all these facts, pushing tissue fluid-based diagnosis and monitoring forward to clinical settings faces one major problem: its accessibility. Most extracellular tissue fluid, such as interstitial fluid (ISF), is abundant but hard to collect, and the currently available technologies are invasive and expensive. This is where novel microneedle technology can help tackle this significant obstacle. The ability of microneedle technology to minimally invasively access tissue fluid-containing biomarkers will enable ISF and other tissue fluid utilization in the clinical diagnosis and monitoring of localized diseases. This review attempts to present the current pursuit of the application of microneedle systems as a diagnostic and monitoring platform, along with the recent progress of biomarker detection in diagnosing and monitoring localized external organ diseases. Then, the potential use of various microneedles in future clinical diagnostics and monitoring of localized diseases is discussed by presenting the currently studied cases.

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microRNA profiling for early detection of nonmelanoma skin cancer

Abstract: Our study suggests that the miRNAs with significant changes in expression (miR-19a-3p, miR-25-3p, miR-30a-5p, miR-145-5p and miR-186-5p) could serve as novel noninvasive biomarkers for detection of NMSC.

Cited by 35 publications

References 23 publications

MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor

MicroRNA-186-5p overexpression modulates colon cancer growth by repressing the expression of the FAM134B tumour inhibitor

Molecular Mechanisms and Biomarkers of Skin Photocarcinogenesis

Where Microneedle Meets Biomarkers: Futuristic Application for Diagnosing and Monitoring Localized External Organ Diseases

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