MicroRNA profiling of second trimester maternal plasma shows upregulation of miR-195-5p in patients with gestational diabetes

Tagoma, Aili; Alnek, Kristi; Kirss, Anne; Uibo, Raivo; Haller-Kikkatalo, Kadri

doi:10.1016/j.gene.2018.06.004

Cited by 56 publications

(109 citation statements)

References 45 publications

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Analysis of the circulating miRNA profiles in peripheral blood has revealed that miR-1275, miR-16-5p, miR-17-5p, miR-19a-3p, miR-19b-3p, miR-20a-5p, miR-195-5p and miR-3664-3p are significantly upregulated in GDM pregnancies compared with those in normal pregnancies. In contrast, miR-29a, miR-132, miR-142-5p, miR-222 and miR-4666a-3p were found to be downregulated in women affected by GDM [51][52][53][54][55][56][57]. RNA sequencing has revealed that miR-138-5p is significantly downregulated in GDM placentas [53].…”

Section: Peripheral Blood Exosomes and Circulating Mirnas In Gestatiomentioning

confidence: 98%

Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities

Yang

Wang

et al. 2020

J Transl Med

View full text Add to dashboard Cite

During pregnancy in humans, the physiology of the mother and foetus are finely regulated by many factors. Inappropriate regulation can result in pregnancy disorders, such as complications and foetal abnormalities. The early prediction or accurate diagnosis of related diseases is a concern of researchers. Liquid biopsy can be analysed for circulating cells, cell-free nucleic acids, and exosomes. Because exosomes can be detected in the peripheral blood of women in early pregnancy, these vesicles and their contents have become the focus of early prediction or diagnostic biomarker research on pregnancy complications and foetal developmental disorders. In this review, we focus on recent studies addressing the roles of peripheral blood exosomes and circulating miRNAs in pregnancy complications and in pregnancies with abnormal foetal developmental disorders, with particular attention paid to the potential application value of exosomes and circulating miRNAs as disease-specific biomarkers.

show abstract

Section: Peripheral Blood Exosomes and Circulating Mirnas In Gestatiomentioning

confidence: 98%

Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities

Yang

Wang

et al. 2020

J Transl Med

View full text Add to dashboard Cite

show abstract

“…However, most of microRNAs, which were the subjects of our interest, have not yet been observed by other investigators to be dysregulated in maternal circulation (peripheral blood, plasma, or serum samples) of women with clinically established GDM or before the onset of GDM [20,21,37,80,92,143,149,[172][173][174][175][176]. So, it is feasible that epigenetic profiles of a series of microRNAs have also been changing with time by force of various circumstances as a result of the interaction between genetic and environmental factors [177].…”

Section: Discussionmentioning

confidence: 88%

“…Moreover, a set of circulating microRNAs associated with cardiovascular/cerebrovascular diseases (miR-16-5p, miR-17-5p, miR-20a-5p, miR-29a-3p, miR-125b-5p, and miR-195-5p) was reported by several independent studies [20,21,80,92,143,172,173] to be upregulated during various gestational ages in serum or plasma of mothers with already-diagnosed GDM or mothers who were destined to develop GDM later during pregnancy. The data resulting from these prenatally ongoing studies and interaction network analysis [20,21,80,92,98,125,143,172,173] may support our current finding referring to upregulated expression profile of these particular microRNAs in whole peripheral blood of women with a prior exposure to GDM.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus and Cardiovascular Risk Assessment in Mothers with a History of Gestational Diabetes Mellitus Based on Postpartal Expression Profile of MicroRNAs Associated with Diabetes Mellitus and Cardiovascular and Cerebrovascular Diseases

Hromadníková

Dvořáková

Krofta

2020

IJMS

View full text Add to dashboard Cite

Mothers with a history of gestational diabetes mellitus (GDM) have an increased risk of developing diabetes in the future and a lifelong cardiovascular risk. Postpartal expression profile of cardiovascular/cerebrovascular disease associated microRNAs was assessed 3–11 years after the delivery in whole peripheral blood of young and middle-aged mothers with a prior exposure to GDM with the aim to identify a high-risk group of mothers at risk of later development of diabetes mellitus and cardiovascular/cerebrovascular diseases who would benefit from implementation of early primary prevention strategies and long-term follow-up. The hypothesis of the assessment of cardiovascular risk in women was based on the knowledge that a series of microRNAs play a role in the pathogenesis of diabetes mellitus and cardiovascular/cerebrovascular diseases. Abnormal expression profile of multiple microRNAs was found in women with a prior exposure to GDM (miR-1-3p, miR-16-5p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-24-3p, miR-26a-5p, miR-29a-3p, miR-100-5p, miR-103a-3p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-199a-5p, miR-221-3p, miR-342-3p, miR-499a-5p, and-miR-574-3p). Postpartal combined screening of miR-1-3p, miR-16-5p, miR-17-5p, miR-20b-5p, miR-21-5p, miR-23a-3p, miR-26a-5p, miR-29a-3p, miR-103a-3p, miR-133a-3p, miR-146a-5p, miR-181a-5p, miR-195-5p, miR-199a-5p, miR-221-3p, and miR-499a-5p showed the highest accuracy for the identification of mothers with a prior exposure to GDM at a higher risk of later development of cardiovascular/cerebrovascular diseases (AUC 0.900, p < 0.001, sensitivity 77.48%, specificity 93.26%, cut off >0.611270413). It was able to identify 77.48% mothers with an increased cardiovascular risk at 10.0% FPR. Any of changes in epigenome (upregulation of miR-16-5p, miR-17-5p, miR-29a-3p, and miR-195-5p) that were induced by GDM-complicated pregnancy are long-acting and may predispose mothers affected with GDM to later development of diabetes mellitus and cardiovascular/cerebrovascular diseases. In addition, novel epigenetic changes (upregulation of serious of microRNAs) appeared in a proportion of women that were exposed to GDM throughout the postpartal life. Likewise, a previous occurrence of either GH, PE, and/or FGR, as well as a previous occurrence of GDM, is associated with the upregulation of miR-1-3p, miR-17-5p, miR-20a-5p, miR-20b-5p, miR-29a-3p, miR-100-5p, miR-125b-5p, miR-126-3p, miR-130b-3p, miR-133a-3p, miR-143-3p, miR-145-5p, miR-146a-5p, miR-181a-5p, miR-199a-5p, miR-221-3p, and miR-499a-5p. On the other hand, upregulation of miR-16-5p, miR-21-5p, miR-23a-3p, miR-24-3p, miR-26a-5p, miR-103a-3p, miR-195-5p, miR-342-3p, and miR-574-3p represents a unique feature of aberrant expression profile of women with a prior exposure to GDM. Screening of particular microRNAs may stratify a high-risk group of mothers with a history of GDM who might benefit from implementation of early primary prevention strategies.

show abstract

“…They also reported the decreased expression of miR-20a, which was a significant predictor of GDM. Conversely, Tagoma et al [61] reported increased expression of plasma-derived miR-222 in Finnish women with GDM compared with controls, while miR-20a was increased in Chinese women with GDM compared with controls. [62] Furthermore, many studies have demonstrated that placenta-specific miRNAs are altered in pregnancy complications, such as preeclampsia, macrosomia, preterm delivery, pregnancy loss and smallfor-gestational-age babies, which further supports the use of miRNAs as predictive biomarkers for adverse pregnancy outcomes.…”

Section: Epigeneticsmentioning

confidence: 92%

Screening and diagnosis of gestational diabetes mellitus in South Africa: What we know so far

2019

View full text Add to dashboard Cite

The early detection and management of gestational diabetes mellitus (GDM) present an ideal opportunity to decrease perinatal complications and adverse long-term health outcomes in mothers and their offspring. This review describes the major GDM screening and diagnostic strategies used worldwide, including novel screening and diagnostic methods that are being explored. It highlights the varied screening and diagnostic strategies currently employed in South Africa (SA). The lack of uniform GDM diagnostic criteria and variation in clinical practice hamper early detection and management of GDM, which negatively affects maternal and child health. We recommend that an SA diabetes-in-pregnancy study group, comprising interested obstetricians, physicians, endocrinologists, public health specialists, dieticians and scientists, be established to make evidence-based recommendations on affordable, accessible and applicable GDM screening and diagnostic and management strategies.

show abstract

MicroRNA profiling of second trimester maternal plasma shows upregulation of miR-195-5p in patients with gestational diabetes

Cited by 56 publications

References 45 publications

Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities

Clinical application of exosomes and circulating microRNAs in the diagnosis of pregnancy complications and foetal abnormalities

Diabetes Mellitus and Cardiovascular Risk Assessment in Mothers with a History of Gestational Diabetes Mellitus Based on Postpartal Expression Profile of MicroRNAs Associated with Diabetes Mellitus and Cardiovascular and Cerebrovascular Diseases

Screening and diagnosis of gestational diabetes mellitus in South Africa: What we know so far

Contact Info

Product

Resources

About