MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1

Jung, Kwang Hwa; McCarthy, Ryan L.; Zhou, Chong; Uprety, Nadima; Barton, Michelle C.

doi:10.1002/stem.2283

Cited by 39 publications

(31 citation statements)

References 47 publications

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“…Although it can be treated by surgery and chemotherapy, the clinical prognosis remains poor. In recent years, many studies have indicated that miRNAs play a role in the development of osteosarcoma, with several miRNAs found to be aberrantly expressed in osteosarcoma development [11-13]. Our study demonstrated that miR-194 may play an antioncogenic role in the development of osteosarcoma.…”

Section: Discussionsupporting

confidence: 58%

miR-194 Suppresses Proliferation and Migration and Promotes Apoptosis of Osteosarcoma Cells by Targeting CDH2

Miao

Wang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Studies have shown that miR-194 functions as a tumour suppressor and is associated with tumour growth and metastasis. This study intends to uncover the mechanism of tumour suppression by miR-194. The expression of miR-194 in osteosarcoma cell lines and tissues were monitored by real-time PCR. Methods: The proliferation ability was examined by MTT assay. Migration and apoptosis of cells were monitored by migration assay and flow cytometry, respectively. The regulation of miR-194 on CDH2 was determined by luciferase assays and western blot assays. Results: The results showed that miR-194 was significantly reduced in osteosarcoma compared with that in normal bone tissue. Overexpression of miR-194 significantly attenuated the proliferation and migration and induced the apoptosis of osteosarcoma cells. Furthermore, we demonstrated that miR-194 has inhibited the malignant behaviour of osteosarcoma by downregulating CDH2 expression. Conclusions: These findings suggested that miR-194 may act as a tumour suppressor in osteosarcoma. miR-194/CDH2 may be a novel therapeutic target in the treatment of osteosarcoma.

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Section: Discussionsupporting

confidence: 58%

miR-194 Suppresses Proliferation and Migration and Promotes Apoptosis of Osteosarcoma Cells by Targeting CDH2

Miao

Wang

et al. 2018

Cell Physiol Biochem

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“…miR‐194 has been reported to act a great role in numerous physiological and pathological pathways. For instance, overexpression of miR‐194 can decrease stellate cell activation (Venugopal et al, ), modulate hepatocytic differentiation of progenitor cells (Jung et al, ) and osteoblast differentiation (Li et al, ). In addition, miR‐194 is involved in Toll‐Like Receptor 4 Inflammatory Responses in THP‐1 Cells (Tian et al, ).…”

Section: Discussionmentioning

confidence: 99%

miR‐194 functions as a novel modulator of cellular senescence in mouse embryonic fibroblasts

Zhang

Zhu

et al. 2017

Cell Biology International

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MicroRNA-194 (miR-194), a typical p53 responsive miRNA, serves as a tumor suppressor similar as p53, and has been demonstrated to play an anti-proliferation role in various human cancers. In spite of the pivotal role of p53 during aging process, the knowledge of miR-194's contribution to cellular senescence is limited. We herein sought to explore the role of miR-194 in the replicative senescence and stress-induced senescence of mouse embryonic fibroblasts. Our results unraveled that, compared to young cells, miR-194 is highly expressed in senescent cells, and extra expression of miR-194 significantly triggers the replicative senescence of MEFs and H O -induced senescence of NIH/3T3 cells, while inhibition of miR-194 exhibited the opposite effect. We further unveiled that DNMT3A was a direct and authentic target of miR-194, which has been reported to be closely associated with cellular senescence. Taken together, our data suggest that miR-194 may significantly promote the development of cellular senescence in mouse embryonic fibroblasts, which potentially occurs through inhibiting the DNMT3A expression.

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“…The regulation of cell development for producing differentiated and mature cells is based on gene expression and transcriptional regulators. For example, miR‐1 and miR‐133 are modulatory molecules of the skeletal muscle proliferation and differentiation (Chen et al, ), miR‐23a has an inhibitory function on osteogenesis of human bone marrow mesenchymal stem cells (hBM‐MSCs) (Li et al, ), miR‐194 controls hepatocytic differentiation of the progenitor cells (Jung et al, ), and miR‐99b, ‐181a, and ‐181b play essential roles in the differentiation of human embryonic stem cells (hESCs) toward vascular endothelial cells (Kane et al, ), while transfection of hiPSCs with miR‐186 and miR‐375 leads to islet‐like cell clusters differentiation (Shaer et al, ). Differentiation of different sources of cells to islet‐like structures has been reported in several studies and in some cases miRNAs were applied to conduct this differentiation process.…”

Section: Introductionmentioning

confidence: 99%

The role of microRNAs in islet β‐cell development

Kaviani

Azarpira

Karimi

et al. 2016

Cell Biology International

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Cell-based therapies suggest novel treatments to overcome the complication of the current therapeutic approaches in diabetes mellitus type 1. Replacement of the destroyed pancreatic islet β-cells by appropriate alternative cells needs an efficient approach to differentiate the cells into viable and functional insulin producing cells. Small non-coding RNA molecules, microRNAs (miRNA), have critical roles in post-transcriptional regulation of gene expression. Therefore, they can direct the cells toward β-cell like cells and control islet β-cell development. Previous reports showed the manipulation of the miRNA expression on islet β-cell differentiation and regeneration. Likewise, the regulation of epithelial to mesenchymal transi-tion by the miR-30 family and the miR-200 family may be a useful approach to conduct islet β-cell development. Investigation of stem cells differentiation showed that the dynamic expression patterns of miR-375 and miR-7 are similar to developing human fetal pancreas while dynamic expression of miR-146a and miR-34a occurred during the differentiation. Moreover, miR-342 and its both targets, FOXA2 and MAFB, are found in β-cell differentiation and maturation. Because miRNAs can target specific transcription factors during islet β-cell development and differentiation, they could be offerred as alternative regenerative treatment for diabetes mellitus. Considering that the application of these non-coding RNAs remains limited in the literature, in this review article, we present an overview of the roles of miRNAs in the islet β-cell development, focusing on the application of different miRNAs in the experimental protocols.

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MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1

Cited by 39 publications

References 47 publications

miR-194 Suppresses Proliferation and Migration and Promotes Apoptosis of Osteosarcoma Cells by Targeting CDH2

miR-194 Suppresses Proliferation and Migration and Promotes Apoptosis of Osteosarcoma Cells by Targeting CDH2

miR‐194 functions as a novel modulator of cellular senescence in mouse embryonic fibroblasts

The role of microRNAs in islet β‐cell development

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