microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs

Eipper-Mains, Jodi; Kiraly, Drew D.; Palakodeti, Dasaradhi; Mains, Richard E.; Eipper, Betty A.; Graveley, Brenton R.

doi:10.1261/rna.2775511

Cited by 120 publications

(147 citation statements)

References 66 publications

(92 reference statements)

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“…Next generation sequencing recently identified tens of miRNAs that are altered in NAc whole extracts and in purified striatal postsynaptic densities after chronic cocaine 166 . Among these, cocaine increased expression of miR-181a and decreased expression of miR-124 and let-7d in rat striatum 126; 167; 168; 169; 170 .…”

Section: Epigenetics and Addictionmentioning

confidence: 99%

Epigenetic Signaling in Psychiatric Disorders

Peña

Bagot

Labonté

et al. 2014

Journal of Molecular Biology

134

145

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Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in neural circuit structure and function. While genetic factors are important in the etiology of disorders such as depression and addiction, relatively high rates of discordance among identical twins clearly indicate the importance of additional mechanisms. Environmental factors such as stress or prior drug exposure are known to play a role in the onset of these illnesses. Such exposure to environmental insults induces stable changes in gene expression, neural circuit function, and ultimately behavior, and these maladaptations appear distinct between developmental and adult exposures. Increasing evidence indicates that these sustained abnormalities are maintained by epigenetic modifications in specific brain regions. Indeed, transcriptional dysregulation and associated aberrant epigenetic regulation is a unifying theme in psychiatric disorders. Aspects of depression and addiction can be modeled in animals by inducing disease-like states through environmental manipulations (e.g., chronic-stress, drug administration). Understanding how environmental factors recruit the epigenetic machinery in animal models is revealing new insight into disease mechanisms in humans.

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Section: Epigenetics and Addictionmentioning

confidence: 99%

Epigenetic Signaling in Psychiatric Disorders

Peña

Bagot

Labonté

et al. 2014

Journal of Molecular Biology

134

145

View full text Add to dashboard Cite

show abstract

“…Several genes implicated in addiction models such as ΔFosB, dopamine transporter, and glutamate receptor subunits, have also been related to drug-triggered alterations in specific miRNAs [26]. Moreover, miRNAs are altered in NAc after chronic cocaine use [27]. However, extensive researches on miRNA affected by chronic substance intake and its relationship have yet to be elucidated.…”

Section: Histone Modificationmentioning

confidence: 99%

The Role of Epigenetic Mechanisms in Substance Use Disorders: An Overview

Umesh¹,

Crj²,

Simlai³

et al. 2015

Hereditary Genet

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Substance use disorder" (SUD) is a common, chronic, remitting/relapsing group of psychiatric disorders having devastating effect not only on the individual but also impose socio-economic burden on their families and the society at large. They are often accompanied with numerous maladaptive behaviors and a persistent and compulsive, uncontrolled use of substance. Interestingly, they have moderate to high heritability and seem to be modulated by both genes and environment. Recent researches suggest that interactions of environmental and genetic factors designate the significance of epigenetic mechanisms, which have been found to occur in SUDs. This review makes an attempt to provide an overview regarding the various types of epigenetic modifications and their application in relation to SUDs.

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“…Finally, next-generation miRNA sequencing, microRNA-Seq, was used to identify cocaine-regulated miRNAs in the nucleus accumbens and striatal synapses. A number of miRNAs were identified that exhibit cocaine-induced expression changes, such as the miR-8 family members miR-429 and miR-200a/b (Eipper-Mains et al 2011). miRNAs are also involved in modulating brain physiology underlying alcohol addiction. In the adult mammalian brain, alcohol exposure rapidly up-regulates miR-9 expression levels in the striatum and supraoptic nucleus (SON).…”

Section: Micrornas In Drug Addictionmentioning

confidence: 99%

MicroRNAs in learning, memory, and neurological diseases: Figure 1.

2012

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MicroRNAs (miRNAs) represent a class of small regulatory noncoding RNAs 22 bp in length that mediate post-transcriptional silencing of gene expression via the recognition of specific sequences in target messenger (m)RNAs. The current body of literature suggests that miRNAs are fine-tuning regulators of gene expression profiles in a wide range of biological processes, from development to cancer. Many miRNAs are highly expressed in the adult nervous system in a spatially and temporally controlled manner in normal physiology, as well as in certain pathological conditions. These findings emphasize that gene regulation networks based on miRNA activities may be particularly important to brain function, and that perturbation of these networks may result in abnormal brain function. Indeed, miRNAs have been implicated in various aspects of dendrite remodeling and synaptic plasticity, as well as in experience-dependent adaptive changes of neural circuits in the postnatal developmental and adult brain. Recent advances in methods of next-generation sequencing, such as RNA-seq, offer the means to quantitatively evaluate the functions of miRNAs in a genome-wide manner in large cohorts of samples. These new technologies have already yielded valuable information and are expanding our understanding of miRNA-based mechanisms in higher-order brain processing, including learning and memory and cognition, as well as in neuropsychiatric disorders.

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microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs

Cited by 120 publications

References 66 publications

Epigenetic Signaling in Psychiatric Disorders

Epigenetic Signaling in Psychiatric Disorders

The Role of Epigenetic Mechanisms in Substance Use Disorders: An Overview

MicroRNAs in learning, memory, and neurological diseases: Figure 1.

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