MicroRNA signature analysis in colorectal cancer: identification of expression profiles in stage II tumors associated with aggressive disease

Chang, Kah Hoong; Miller, Nicola; Kheirelseid, Elrasheid; Lemetre, Christophe; Ball, Graham; Smith, Myles; Regan, Michael J.; McAnena, O. J.; Kerin, Michael J.

doi:10.1007/s00384-011-1279-4

Cited by 95 publications

(71 citation statements)

References 42 publications

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“…Increased expression of miR-10b was associated with tumors 17 located in the colon relative to the rectum and with poorly differentiated tumors. MiR-10b has previously been reported to be downregulated in CRC and increased expression was associated with increased pT-stage [42]. We did, however, not observe association with pT stage.…”

Section: Discussioncontrasting

confidence: 55%

“…FOBT is an over-the-counter test which detects occult blood in feces. The use of FOBT has been shown in different randomized trials to reduce cancer mortality [39] but their application in screening is still debated [40] as test from different 24 manufacturers has a variable sensitivity (40%-80%) resulting in many false negatives [41,42].…”

Section: E) Early Detection and Screeningmentioning

confidence: 99%

“…MiR-10b-5p has previously been associated with increased pT stage in CRC [252]. Examining the top five highly expressed miRNAs for association with clinicopathological parameters revealed that reduced expression of miR-192-5p was associated with increased pT stage and poorly differentiated tumors.…”

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confidence: 99%

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Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients

et al. 2011

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Section: Discussioncontrasting

confidence: 55%

Section: E) Early Detection and Screeningmentioning

confidence: 99%

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Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients

et al. 2011

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“…miR-10b overexpression was associated with poor prognosis in breast cancer37 and gliomas 38. In colon cancer, miR-10b showed increasing expression in higher stage disease 39. In gastric cancer, increased miR-10b expression was associated with decreased survival 40.…”

Section: Discussionmentioning

confidence: 99%

miR-10b is a prognostic marker in clear cell renal cell carcinoma

et al. 2017

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“…Our miRNA target prediction analyses revealed that miR-139-5p could potentially target NDRG4 (Wingless-type MMTV integration site family member 4) in ACC. Very interestingly, NDRG4 has been reported as a candidate tumor suppressor gene and potential biomarker for colorectal cancer (Melotte et al 2009) while a more recent study demonstrated that miR-139-5p was upregulated in aggressive colorectal tumors (Chang et al 2011). MiR-376a belongs to the large 14q32 miRNA cluster, which lies within a parentally imprinted chromosomal area.…”

Section: Discussionmentioning

confidence: 99%

Serum miR-483-5p and miR-195 are predictive of recurrence risk in adrenocortical cancer patients

Chabre¹,

Libé²,

Assié³

et al. 2013

Endocrine-Related Cancer

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Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Local and distant recurrences occur in a subset of tumors classified as 'aggressive' ACC (aACC), as opposed to 'non-aggressive' ACC (naACC). In this study, we investigated whether tissue and serum microRNAs (miRNAs) are predictive of ACC prognosis. Tissue miRNA expression profiles were determined using microarrays in a test series of six adrenocortical adenomas (ACAs), six naACCs, and six aACCs. Eight miRNAs were selected for further validation by quantitative RT-PCR (ten ACAs, nine naACCs, nine aACCs, and three normal adrenals). Serum levels of five miRNAs were measured in samples from 56 subjects (19 healthy controls (HC), 14 ACA, nine naACC, and 14 aACC patients). MiR-195 and miR-335 levels were significantly decreased in both tumor and serum samples of ACC patients relative to ACA patients or HC. MiR-139-5p and miR-376a levels were significantly increased in aACC compared with naACC patients in tumor samples only. Tissue miR-483-5p was markedly upregulated in a majority of ACC compared with ACA patients or HC, but most importantly, serum miR-483-5p was detected only in aACC patients. High circulating levels of miR-483-5p or low circulating levels of miR-195 were associated with both shorter recurrence-free survival (PZ0.0004 and PZ0.0014 respectively) and shorter overall survival (PZ0.0005 and PZ0.0086 respectively). In conclusion, this study reports for the first time that circulating miR-483-5p and miR-195 are promising noninvasive biomarkers with a highly specific prognostic value for the clinical outcome of ACC patients.

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MicroRNA signature analysis in colorectal cancer: identification of expression profiles in stage II tumors associated with aggressive disease

Abstract: Association of specific miRNAs with clinicopathological features indicates their biological relevance and highlights the power of ANN to reliably predict clinically relevant miRNA biomarkers, which it is hoped will better stratify patients to guide adjuvant therapy.

Cited by 95 publications

References 42 publications

Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients

Investigation of nonspecific cross-reacting antigen 2 as a prognostic biomarker in bone marrow plasma from colorectal cancer patients

miR-10b is a prognostic marker in clear cell renal cell carcinoma

Serum miR-483-5p and miR-195 are predictive of recurrence risk in adrenocortical cancer patients

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