MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States

Vasu, Srividya; Kumano, Kenjiro; Darden, Carly M.; Rahman, Irum; Lawrence, Michael C.; Naziruddin, Bashoo

doi:10.3390/cells8121533

Cited by 140 publications

(107 citation statements)

References 109 publications

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“…Accumulating evidence highlights miRNAs as important possible biomarkers. However, the complexity of the miRNA landscape associated with human diseases, including diabetes, is so high that it is probably more promising to study miRNA signatures (combinations of multiple miRNA) rather than single miRNA types [65].…”

Section: The Role Of Circulating Non-coding Rnasmentioning

confidence: 99%

The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

Poznyak

Grechko

Poggio

et al. 2020

IJMS

681

359

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Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a common main feature of chronic hyperglycemia that results from defects of insulin secretion, insulin action, or both. Insulin is an important anabolic hormone, and its deficiency leads to various metabolic abnormalities in proteins, lipids, and carbohydrates. Atherosclerosis develops as a result of a multistep process ultimately leading to cardiovascular disease associated with high morbidity and mortality. Alteration of lipid metabolism is a risk factor and characteristic feature of atherosclerosis. Possible links between the two chronic disorders depending on altered metabolic pathways have been investigated in numerous studies. It was shown that both types of diabetes mellitus can actually induce atherosclerosis development or further accelerate its progression. Elevated glucose level, dyslipidemia, and other metabolic alterations that accompany the disease development are tightly involved in the pathogenesis of atherosclerosis at almost every step of the atherogenic process. Chronic inflammation is currently considered as one of the key factors in atherosclerosis development and is present starting from the earliest stages of the pathology initiation. It may also be regarded as one of the possible links between atherosclerosis and diabetes mellitus. However, the data available so far do not allow for developing effective anti-inflammatory therapeutic strategies that would stop atherosclerotic lesion progression or induce lesion reduction. In this review, we summarize the main aspects of diabetes mellitus that possibly affect the atherogenic process and its relationship with chronic inflammation. We also discuss the established pathophysiological features that link atherosclerosis and diabetes mellitus, such as oxidative stress, altered protein kinase signaling, and the role of certain miRNA and epigenetic modifications.

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Section: The Role Of Circulating Non-coding Rnasmentioning

confidence: 99%

The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

Poznyak

Grechko

Poggio

et al. 2020

IJMS

681

359

View full text Add to dashboard Cite

show abstract

“…However, it is important to evaluate whether and how novel miRNA findings are associated with relevant clinical outcomes. Moreover, intrinsic and extrinsic elements such as sex [ 196 ], age [ 197 ], type of biological sample [ 198 ], diabetes duration [ 199 ], method of profiling [ 200 ] as well as pre-analytic factor such as hemolysis of samples or covariates of DFU, such as decreased nutritional state of the patient, smoking, peripheral limb ischemia, etc., [ 201 ] may affect miRNA expression levels ( Table 3 ).…”

Section: Circulating and Tissue Micrornas As Biomarkers For The Eamentioning

confidence: 99%

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Petković

Sørensen

Leal

et al. 2020

Cells

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Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers.

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“…It can be hypothesized that genetic factors play a role in the progression form prediabetes to diabetes. miRNAs, as important mediators of cell-to-cell communication and coordinators of many biological functions, could be useful markers and thus suitable to implement the monitoring and identifying of high-risk individuals for T2DM development before the metabolic imbalance sets in [ 48 ]. Thus, new potential miRNA biomarkers indicative of developing diabetes in the future are needed.…”

Section: Discussionmentioning

confidence: 99%

Circulating miRNAs as a Predictive Biomarker of the Progression from Prediabetes to Diabetes: Outcomes of a 5-Year Prospective Observational Study

Sidorkiewicz

Niemira

Maliszewska

et al. 2020

JCM

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Due to a global increase in the prevalence of type 2 diabetes mellitus (T2DM), there is an urgent need for early identification of prediabetes, as these people have the highest risk of developing diabetes. Circulating miRNAs have shown potential as progression biomarkers in other diseases. This study aimed to conduct a baseline comparison of serum-circulating miRNAs in prediabetic individuals, with the distinction between those who later progressed to T2DM and those who did not. The expression levels of 798 miRNAs using NanoString technology were examined. Spearman correlation, receiver operating characteristic (ROC) curve analysis, and logistic regression modeling were performed. Gene ontology (GO) and canonical pathway analysis were used to explore the biological functions of the miRNA target genes. The study revealed that three miRNAs were upregulated in the serum samples of patients who later progressed to T2DM. Pathway analysis showed that the miRNA target genes were mainly significantly enriched in neuronal NO synthase (nNOS) signaling in neurons, amyloid processing, and hepatic cholestasis. ROC analysis demonstrated that miR-491-5p, miR-1307-3p, and miR-298 can be introduced as a diagnostic tool for the prediction of T2DM (area under the curve (AUC) = 94.0%, 88.0%, and 84.0%, respectively). Validation by real-time quantitative polymerase chain reaction (qRT-PCR) confirmed our findings. The results suggest that circulating miRNAs can potentially be used as predictive biomarkers of T2DM in prediabetic patients.

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MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes States

Cited by 140 publications

References 109 publications

The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

Mechanistic Actions of microRNAs in Diabetic Wound Healing

Circulating miRNAs as a Predictive Biomarker of the Progression from Prediabetes to Diabetes: Outcomes of a 5-Year Prospective Observational Study

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