MicroRNA therapeutics and nucleic acid nano-delivery systems in bacterial infection: a review

Li, Ze; Lei, Zhixin; Cheng, Dong‐Bing; Sun, Tao

doi:10.1039/d3tb00694h

J. Mater. Chem. B

2023

DOI: 10.1039/d3tb00694h

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MicroRNA therapeutics and nucleic acid nano-delivery systems in bacterial infection: a review

Ze Li¹,

Zhixin Lei²,

Dong‐Bing Cheng³

et al.

Abstract: Bacteria that have worked with humans for thousands of years have posed a major threat to human health even today, as drug resistance has become a prominent problem. Compared to...

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2024

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Cited by 3 publications

References 261 publications

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Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence

Sandhanam,

Tamilanban,

Manasa

et al. 2024

Neuroscience

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Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence

Sandhanam,

Tamilanban,

Manasa

et al. 2024

Neuroscience

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A Review of Nanotechnology in microRNA Detection and Drug Delivery

Wang

2024

Cells

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MicroRNAs (miRNAs) are small, non-coding RNAs that play a crucial role in regulating gene expression. Dysfunction in miRNAs can lead to various diseases, including cancers, neurological disorders, and cardiovascular conditions. To date, approximately 2000 miRNAs have been identified in humans. These small molecules have shown promise as disease biomarkers and potential therapeutic targets. Therefore, identifying miRNA biomarkers for diseases and developing effective miRNA drug delivery systems are essential. Nanotechnology offers promising new approaches to addressing scientific and medical challenges. Traditional miRNA detection methods include next-generation sequencing, microarrays, Northern blotting, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Nanotechnology can serve as an effective alternative to Northern blotting and RT-qPCR for miRNA detection. Moreover, nanomaterials exhibit unique properties that differ from larger counterparts, enabling miRNA therapeutics to more effectively enter target cells, reduce degradation in the bloodstream, and be released in specific tissues or cells. This paper reviews the application of nanotechnology in miRNA detection and drug delivery systems. Given that miRNA therapeutics are still in the developing stages, nanotechnology holds great promise for accelerating miRNA therapeutics development.

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Oral Nanoformulations in Cardiovascular Medicine: Advances in Atherosclerosis Treatment

Sun,

Jia,

Tan

et al. 2024

Pharmaceuticals

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Atherosclerosis (AS) is the formation of atherosclerotic plaques on the walls of the arteries, causing them to narrow. If this occurs in the coronary arteries, the blood vessels may be completely blocked, resulting in myocardial infarction; if it occurs in the blood vessels of the brain, the blood vessels may be blocked, resulting in cerebral infarction, i.e., stroke. Studies have shown that the pathogenesis of atherosclerosis involves the processes of inflammation, lipid infiltration, oxidative stress, and endothelial damage, etc. SIRT, as a key factor regulating the molecular mechanisms of oxidative stress, inflammation, and aging, has an important impact on the pathogenesis of plaque formation, progression, and vulnerability. Statistics show that AS accounts for about 50 per cent of deaths in Western countries. Currently, oral medication is the mainstay of AS treatment, but its development is limited by side effects, low bioavailability and other unfavourable factors. In recent years, with the rapid development of nano-preparations, researchers have combined statins and natural product drugs within nanopreparations to improve their bioavailability. Based on this, this paper summarises the main pathogenesis of AS and also proposes new oral nanoformulations such as liposomes, nanoparticles, nanoemulsions, and nanocapsules to improve their application in the treatment of AS.

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MicroRNA therapeutics and nucleic acid nano-delivery systems in bacterial infection: a review

Abstract: Bacteria that have worked with humans for thousands of years have posed a major threat to human health even today, as drug resistance has become a prominent problem. Compared to...

Cited by 3 publications

References 261 publications

Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence

Unlocking novel therapeutic avenues in glioblastoma: Harnessing 4-amino cyanine and miRNA synergy for next-gen treatment convergence

A Review of Nanotechnology in microRNA Detection and Drug Delivery

Oral Nanoformulations in Cardiovascular Medicine: Advances in Atherosclerosis Treatment

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