MicroRNA1 influences cardiac differentiation in
            <i>Drosophila</i>
            and regulates Notch signaling

Kwon, Chulan; Han, Zhe; Olson, Eric N.; Srivastava, Deepak

doi:10.1073/pnas.0509535102

Cited by 405 publications

(355 citation statements)

References 38 publications

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“…miRNA-1 and miRNA-133 are expressed in cardiac and skeletal muscle and are transcriptionally regulated by the myogenic differentiation factors MyoD, Mef2, and SRF (18)(19)(20)(21). In Drosophila, deletion of the single miRNA-1 gene results in a defect in muscle differentiation or maintenance (20,21).…”

mentioning

confidence: 99%

Distinctive patterns of microRNA expression in primary muscular disorders

Eisenberg

Eran

Nishino

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

460

518

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The primary muscle disorders are a diverse group of diseases caused by various defective structural proteins, abnormal signaling molecules, enzymes and proteins involved in posttranslational modifications, and other mechanisms. Although there is increasing clarification of the primary aberrant cellular processes responsible for these conditions, the decisive factors involved in the secondary pathogenic cascades are still mainly obscure. Given the emerging roles of microRNAs (miRNAs) in modulation of cellular phenotypes, we searched for miRNAs regulated during the degenerative process of muscle to gain insight into the specific regulation of genes that are disrupted in pathological muscle conditions. We describe 185 miRNAs that are up- or down-regulated in 10 major muscular disorders in humans [Duchenne muscular dystrophy (DMD), Becker muscular dystrophy, facioscapulohumeral muscular dystrophy, limb-girdle muscular dystrophies types 2A and 2B, Miyoshi myopathy, nemaline myopathy, polymyositis, dermatomyositis, and inclusion body myositis]. Although five miRNAs were found to be consistently regulated in almost all samples analyzed, pointing to possible involvement of a common regulatory mechanism, others were dysregulated only in one disease and not at all in the other disorders. Functional correlation between the predicted targets of these miRNAs and mRNA expression demonstrated tight posttranscriptional regulation at the mRNA level in DMD and Miyoshi myopathy. Together with direct mRNA–miRNA predicted interactions demonstrated in DMD, some of which are involved in known secondary response functions and others that are involved in muscle regeneration, these findings suggest an important role of miRNAs in specific physiological pathways underlying the disease pathology.

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mentioning

confidence: 99%

Distinctive patterns of microRNA expression in primary muscular disorders

Eisenberg

Eran

Nishino

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

460

518

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“…Hundreds of microRNAs have been identified, most of which are predicted to target multiple mRNAs, suggesting that microRNAs may function as part of an extensive gene regulatory network (3). Indeed, the regulation of conserved developmental signaling pathways (e.g., the Notch, Hedgehog, and TGF␤ pathways) by microRNAs has been reported (5)(6)(7)(8). Activation of the Wg/Wnt pathway by the microRNA miR-315 was also been reported recently (9).…”

mentioning

confidence: 92%

The microRNA miR-8 is a conserved negative regulator of Wnt signaling

Kennell

Gerin

MacDougald

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

178

151

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Wnt signaling plays many important roles in animal development. This evolutionarily conserved signaling pathway is highly regulated at all levels. To identify regulators of the Wnt/Wingless (Wg) pathway, we performed a genetic screen in Drosophila. We identified the microRNA miR-8 as an inhibitor of Wg signaling. Expression of miR-8 potently antagonizes Wg signaling in vivo, in part by directly targeting wntless, a gene required for Wg secretion. In addition, miR-8 inhibits the pathway downstream of the Wg signal by repressing TCF protein levels. Another positive regulator of the pathway, CG32767, is also targeted by miR-8. Our data suggest that miR-8 potently antagonizes the Wg pathway at multiple levels, from secretion of the ligand to transcription of target genes. In addition, mammalian homologues of miR-8 promote adipogenesis of marrow stromal cells by inhibiting Wnt signaling. These findings indicate that miR-8 family members play an evolutionarily conserved role in regulating the Wnt signaling pathway.adipogenesis ͉ TCF ͉ Wntless

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“…A majority of identified miRNAs are highly evolutionarily conserved among many distantly related species, some from worms to human in animals , and mosses to high flowering eudicots in plants (Axtell and Bartel, 2005;Zhang et al, 2006c), suggesting that miRNAs play a very important role in essential biological processes, including developmental timing (Lee et al, 1993), stem cell differentiation (Houbaviy et al, 2003;Hatfield et al, 2005;Zhang et al, 2006b), signaling transduction (Guo et al, 2005;Karp and Ambros, 2005;Kwon et al, 2005), disease (Labourier et al, 2004;Alvarez-Garcia and Miska, 2005), and cancer (Hayashita et al, 2005;Lu et al, 2005b). Currently, miRNAs have been considered one of the most important regulatory molecules, which regulate gene expression at the posttranscriptional levels by targeting mRNAs for direct cleavage of mRNAs or repression of mRNA translation.…”

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confidence: 99%

MicroRNAs and their regulatory roles in animals and plants

Zhang

Wang

Pan

2006

Journal Cellular Physiology

493

307

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microRNAs (miRNAs) are an abundant class of newly identified endogenous non-protein-coding small RNAs. They exist in animals, plants, and viruses, and play an important role in gene silencing. Translational repression, mRNA cleavage, and mRNA decay initiated by miRNA-directed deadenylation of targeted mRNAs are three mechanisms of miRNA-guided gene regulation at the posttranscriptional levels. Many miRNAs are highly conserved in animals and plants, suggesting that they play an essential function in plants and animals. Lots of investigations indicate that miRNAs are involved in multiple biological processes, including stem cell differentiation, organ development, phase change, signaling, disease, cancer, and response to biotic and abiotic environmental stresses. This review provides a general background and current advance on the discovery, history, biogenesis, genomics, mechanisms, and functions of miRNAs.

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MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling

Cited by 405 publications

References 38 publications

Distinctive patterns of microRNA expression in primary muscular disorders

Distinctive patterns of microRNA expression in primary muscular disorders

The microRNA miR-8 is a conserved negative regulator of Wnt signaling

MicroRNAs and their regulatory roles in animals and plants

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