2022
DOI: 10.21203/rs.3.rs-2121570/v1
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MicroRNAs-26 and related osteogenic target genes can play a pivotal role in improving the mechanical and cellular properties of critical-sized foot defects in photobiomodulation and adipose-derived stem cell-based treatments in a rat model

Abstract: Photobiomodulation (PBM) and stem cell-based treatments are relatively invasive methods for treating bone defects. Specific and oriented cellular and molecular functions can be induced by applying an appropriate type of PBMT and ADSs. This study aimed to explore the role of MicroRNAs in the PBM & hADS-based treatments in improving the mechanical and cellular properties of a critical size fracture in a rat model. A critical size femoral defect (CSFD) is induced in both femoral bones of 24 rats. Then a human… Show more

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