MicroRNAs and Adrenocortical Tumors: Where do we Stand on Primary
                    Aldosteronism?

Tömböl, Zsófia; Turai, Péter István; Decmann, Ábel; Igaz, Péter

doi:10.1055/a-1116-2366

Cited by 8 publications

(6 citation statements)

References 83 publications

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“…Steroid profiling by liquid chromatograph-mass spectrometry [ 58 ] and detection of increased 18-oxocortisol and 18-hydroxycortisol levels specifically in APAs harboring potassium inwardly rectifying channel subfamily J member 5 ( KCNJ5 ) mutations [ 59 , 60 ] have been proposed as alternative methods to AVS for classifying the PA subtype. In addition, several microRNAs with differential expression in APA tissues and circulating blood [ 61 , 62 ] have been demonstrated as potential biomarkers useful for subtype diagnosis. Further studies to prove the specificity, sensitivity, and cost effectiveness are needed.…”

Section: When Can We Bypass Avs?mentioning

confidence: 99%

Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism

et al. 2021

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Adrenal venous sampling (AVS) is the key procedure for lateralization of primary hyperaldosteronism (PA) before surgery. Identification of the adrenal veins using computed tomography (CT) and intraoperative cortisol assay facilitates the success of catheterization. Although administration of adrenocorticotropic hormone (ACTH) has benefits such as improving the success rate, some unilateral cases could be falsely diagnosed as bilateral. Selectivity index of 5 with ACTH stimulation to assess the selectivity of catheterization and lateralization index (LI) >4 with ACTH stimulation for unilateral diagnosis is used in many centers. Co-secretion of cortisol from the tumor potentially affects the lateralization by the LI. Patients aged <35 years with hypokalemia, marked aldosterone excess, and unilateral adrenal nodule on CT have a higher probability of unilateral disease. Patients with normokalemia, mild aldosterone excess, and no adrenal tumor on CT have a higher probability of bilateral disease. Although no methods have 100% specificity for subtype diagnosis that would allow bypassing AVS, prediction of the subtype should be considered when recommending AVS to patients. Methodological standardization and strict indication improve diagnostic quality of AVS. Development of non-invasive imaging and biochemical markers will drive a paradigm shift in the clinical practice of PA.

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Section: When Can We Bypass Avs?mentioning

confidence: 99%

Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism

et al. 2021

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“…However, the influence of miRNA on the aldosterone steroidogenic pathway is not confined to CYP11B2 ; we have also shown significant effects on CYP11A1 and CYP21A2 [ 19 ], and it would seem likely that miRNAs are able to control this specific pathway at various stages, even before one considers their influence over the various regulatory mechanisms (primarily the renin–angiotensin system) that stimulate the adrenal cortex to produce aldosterone. Therefore, it seems likely that we have only scratched the surface of the numerous ways in which miRNAs intervene in the regulation, synthesis and action of aldosterone, either in the adrenal cortex or elsewhere [ 22 , 23 , 24 ].…”

Section: Adrenal Mirna In Adrenal Steroidogenesis and Pamentioning

confidence: 99%

Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism

MacKenzie

Saunders

Kralingen

et al. 2021

Cancers

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Primary aldosteronism (PA) is a common and highly treatable condition, usually resulting from adrenocortical tumorous growth or hyperplasia. PA is currently underdiagnosed owing to its complex and protracted diagnostic procedures. A simplified biomarker-based test would be highly valuable in reducing cardiovascular morbidity and mortality. Circulating microRNAs are emerging as potential biomarkers for a number of conditions due to their stability and accessibility. PA is known to alter microRNA expression in adrenocortical tissue; if these changes or their effects are mirrored in the circulating miRNA profile, then this could be exploited by a diagnostic test. However, the reproducibility of studies to identify biomarker-circulating microRNAs has proved difficult for other conditions due to a series of technical challenges. Therefore, any studies seeking to definitively identify circulating microRNA biomarkers of PA must address this in their design. To this end, we are currently conducting the circulating microRNA arm of the ongoing ENS@T-HT study. In this review article, we present evidence to support the utility of circulating microRNAs as PA biomarkers, describe the practical challenges to this approach and, using ENS@T-HT as an example, discuss how these might be overcome.

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“…As a potential marker, miRNAs have also been studied in cardiovascular diseases, endocrine diseases, tumors, etc. (30)(31)(32). Depression is one of the most common mental diseases in the clinic (33).…”

Section: Introductionmentioning

confidence: 99%

Relationship and effect of miR-1-3p expression and BDNF level in patients with primary hypertension complicated with depression

Ding

JIANG

Yang

2022

Cell Mol Biol (Noisy-le-grand)

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This experiment was designed to explore the relationship and effect of miR-1-3p expression and BDNF level in patients with primary hypertension complicated with depression. The subjects of the study were 145 patients with hypertension with a small fluctuation range of blood pressure in recent three months. Within 48 hours after admission, patients were evaluated with the Hospital Anxiety and Depression Scale (HADS) and Hamilton Depression Rating Scale (HAMD). After fasting for 12 hours, enrolled subjects were subject to blood collection (5 ml) in the morning for detecting blood lipid levels, miR-1-3p expression and BDNF by using an automatic biochemical analyzer, real-time fluorescence quantitative PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. Results showed that compared with the normal control group, while miR-1-3p expression increased obviously in patients with hypertension, while the level of BDNF decreased significantly; and compared with patients with simple hypertension, the expression of miR-1-3p in hypertension patients with depression was significantly increased, while BDNF level was decreased evidently (All P < 0.05). miR-1-3p expression in patients with hypertension complicated with depression was negatively correlated with serum BDNF level (r=-0.302, P < 0.05). In relative to the normal control population, the area under the curve (AUC) of ROC produced by serum miR-1-3p and BDNF in patients with primary hypertension complicated with depression was 0.971 (95% CI = 0.945-0.998, P < 0.0001) and 0.875 (95% CI = 0.808-0.942, P < 0.0001); and in relative to primary hypertension patients without depression, the AUC of ROC produced by serum miR-1-3p and BDNF in patients with primary hypertension with depression was 0.957 (95% CI = 0.925-0.989, P < 0.0001) and 0.883 (95% CI = 0.821-0.944, P < 0.0001), respectively. HADS-D score, HAMD score, course of the disease, miR-1-3p expression and BDNF level showed statistical differences in primary hypertension patients with and without depression (All P < 0.05). It was concluded that there are high miR-1-3p expression and low serum BDNF levels in patients with primary hypertension complicated with depression. miR-1-3p has a negative correlation with BDNF, and it may play a role by negatively regulating the expression of BDNF. Detecting miR-1-3p and BDNF in patients with primary hypertension can indicate the occurrence of depression to some extent.

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MicroRNAs and Adrenocortical Tumors: Where do we Stand on Primary Aldosteronism?

Cited by 8 publications

References 83 publications

Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism

Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism

Circulating microRNAs as Diagnostic Markers in Primary Aldosteronism

Relationship and effect of miR-1-3p expression and BDNF level in patients with primary hypertension complicated with depression

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