MicroRNAs and Breast Cancer

Findlay,

doi:10.2174/1874079001003010055

Cited by 4 publications

(4 citation statements)

References 71 publications

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“…Our results were in agreement with other prior studies which reported that miR-21 over-expression was associated with tumor grades, higher proliferation index, and lymph node metastasis in BC [5,13,30,76]. Other previous studies showed that miR-21 levels are positively correlated with vascular invasion, visceral metastasis, and advanced clinical stage [13,46,77], and associated with poor response to therapy, and worse survival in BC [49,[78][79][80][81]. Moreover, miR-21 deregulation represented a global cancer phenomenon; associated with poor prognosis and survival in other cancer types including lung cancer [42,82], colorectal carcinoma [54,83], gastric cancer [84], pancreatic cancer [33], diffuse large B-cell lymphoma [36,37].…”

Section: Discussionsupporting

confidence: 93%

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Pilot Study of Serum MicroRNA-21 as a Diagnostic and Prognostic Biomarker in Egyptian Breast Cancer Patients

et al. 2015

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Section: Discussionsupporting

confidence: 93%

“…status in BC cells, and demonstrated that miR-21 expression is induced by HER2 ? signaling via the mitogen-activated protein kinase (MAPK) pathway [70,77,85]. Another proposed mechanism for this association can be through the linkage of HER2 and miR-21 by chromosomal region amplification.…”

Section: Discussionmentioning

confidence: 99%

Pilot Study of Serum MicroRNA-21 as a Diagnostic and Prognostic Biomarker in Egyptian Breast Cancer Patients

et al. 2015

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“…Blenkiron et al [ 28 ] have previously observed higher expression of miR-145 in luminal-A samples, and miR-145 may be one of the miRNAs related to the breast cancer subtype. In addition, the identified let-7e for the basal-like gain group and miR-21 for the basal-like loss group are all approved to be breast cancer subtype related [ 29 , 30 ]. Furthermore, we used the Cyclus3D algorithm to identify the network motifs that are patterns of subgraphs that recur at frequencies much higher than those found in randomized networks (see Figures 2(a2) – 2(d2) ).…”

Section: Resultsmentioning

confidence: 99%

Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling

Xia

et al. 2015

BioMed Research International

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Breast cancer is a heterogeneous disease with well-defined molecular subtypes. Currently, comparative genomic hybridization arrays (aCGH) techniques have been developed rapidly, and recent evidences in studies of breast cancer suggest that tumors within gene expression subtypes share similar DNA copy number aberrations (CNA) which can be used to further subdivide subtypes. Moreover, subtype-specific miRNA expression profiles are also proposed as novel signatures for breast cancer classification. The identification of mRNA or miRNA expression-based breast cancer subtypes is considered an instructive means of prognosis. Here, we conducted an integrated analysis based on copy number aberrations data and miRNA-mRNA dual expression profiling data to identify breast cancer subtype-specific biomarkers. Interestingly, we found a group of genes residing in subtype-specific CNA regions that also display the corresponding changes in mRNAs levels and their target miRNAs' expression. Among them, the predicted direct correlation of BRCA1-miR-143-miR-145 pairs was selected for experimental validation. The study results indicated that BRCA1 positively regulates miR-143-miR-145 expression and miR-143-miR-145 can serve as promising novel biomarkers for breast cancer subtyping. In our integrated genomics analysis and experimental validation, a new frame to predict candidate biomarkers of breast cancer subtype is provided and offers assistance in order to understand the potential disease etiology of the breast cancer subtypes.

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“…Depending on their targets, miRNAs can function as oncogenes or tumor suppressor genes in different cancers (1). Increasing research has suggested that aberrant expression/functions of miRNAs are associated with the progression of cancer and may serve as novel biomarkers for diagnosis and prognosis in cancers, and may be potential novel therapeutic agents for tumor suppression (2–5). miRNAs are involved in the regulation of cellular functions, including cell proliferation and apoptosis (6).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑4530 suppresses cell proliferation and induces apoptosis by targeting RASA1 in human umbilical vein endothelial cells

Zhang

et al. 2019

Mol Med Report

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MicroRNAs (miRNAs/miRs) are a class of endogenous and non-coding RNAs that are present in eukaryotes. In previous studies, miRNAs have been revealed to have an important role in cell growth and apoptosis. In the present study, the function of a novel and rarely studied miRNA, miR-4530, was investigated in human umbilical vein endothelial cells (HUVECs). The expression level of miR-4530 in HUVECs was investigated using reverse transcription-quantitative polymerase chain reaction following transfection with miR-4530 precursor plasmids, anti-miR-4530 plasmids and empty vector plasmids. Following this, it was revealed that overexpression of miR-4530 can suppress cell proliferation and enhance cell apoptosis. TargetScan analysis suggested that Ras p21 protein activator 1 (RASA1) is a target gene of miR-4530. The results of a dual-luciferase reporter assay also suggested that miR-4530 targets RASA1. Furthermore, the results of dual-luciferase reporter assay suggested that miR-4530 enhanced luciferase activity of the wild-type reporter, but not the mutant RASA1 reporter activity, thus suggesting that miR-4530 enhances the expression of RASA1. In addition, western blot analysis demonstrated that the protein expression level of RASA1 was enhanced following upregulation of miR-4530. The exact mechanism underlying this process has not yet been determined and requires further investigation. In addition, a RASA1 overexpression plasmid vector was transfected into HUVECs. The results suggest that overexpression of RASA1 suppresses cell growth and promotes apoptosis, which was in agreement with the results regarding the overexpression of miR-4530. To investigate how miRNA-4530 affects cellular function, numerous proteins associated with the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT serine/threonine kinase pathways were investigated via western blot analysis. The results suggested that miRNA-4530 suppresses cell proliferation and enhances apoptosis by targeting RASA1 via the ERK/MAPK and PI3K/AKT signaling pathways.

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MicroRNAs and Breast Cancer

Cited by 4 publications

References 71 publications

Pilot Study of Serum MicroRNA-21 as a Diagnostic and Prognostic Biomarker in Egyptian Breast Cancer Patients

Pilot Study of Serum MicroRNA-21 as a Diagnostic and Prognostic Biomarker in Egyptian Breast Cancer Patients

Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling

MicroRNA‑4530 suppresses cell proliferation and induces apoptosis by targeting RASA1 in human umbilical vein endothelial cells

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