2014
DOI: 10.1016/j.ejca.2014.07.012
|View full text |Cite
|
Sign up to set email alerts
|

MicroRNAs and head and neck cancer: Reviewing the first decade of research

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
73
0
1

Year Published

2015
2015
2018
2018

Publication Types

Select...
9

Relationship

0
9

Authors

Journals

citations
Cited by 73 publications
(76 citation statements)
references
References 162 publications
(204 reference statements)
2
73
0
1
Order By: Relevance
“…miRNA-21 in head and neck SCC has been shown to regulate a large number of oncogenic and tumor suppressor targets, including Ras, PDCD4, PTEN, RECK, and HNRPK, and its overexpression has been associated with poor prognosis [38]. Deregulated miRNAs in head and neck SCCs also include: miRNA-155, which downregulates the CDC73 gene and suppresses the cytokine signaling 1 (SOCS1)-STAT3 pathway; the cluster miR-106b, -93 and -25, which targets the p21/CDKN1A pathway; miRNA-130b, regulating the tumor suppressor gene RUNX3, and miR-31 activating the HIF pathway in some cancer types [39]. Moreover, several miRNAs with tumor suppressor activity have also been found deregulated in head and neck cancers.…”
Section: Role Of Mirna In Oropharynx Tumorsmentioning
confidence: 99%
See 1 more Smart Citation
“…miRNA-21 in head and neck SCC has been shown to regulate a large number of oncogenic and tumor suppressor targets, including Ras, PDCD4, PTEN, RECK, and HNRPK, and its overexpression has been associated with poor prognosis [38]. Deregulated miRNAs in head and neck SCCs also include: miRNA-155, which downregulates the CDC73 gene and suppresses the cytokine signaling 1 (SOCS1)-STAT3 pathway; the cluster miR-106b, -93 and -25, which targets the p21/CDKN1A pathway; miRNA-130b, regulating the tumor suppressor gene RUNX3, and miR-31 activating the HIF pathway in some cancer types [39]. Moreover, several miRNAs with tumor suppressor activity have also been found deregulated in head and neck cancers.…”
Section: Role Of Mirna In Oropharynx Tumorsmentioning
confidence: 99%
“…Let-7, whose reduced expression is associated with a poor prognosis, negatively regulates the KRAS oncogene. Other miRNAs with potentially tumor suppressor activities include miRNA-1, -153, -29s, -24, -27a, -34a, -101, -107, -124, -126, -133a, -143, -145, -138, -181a, -200c, -203, -205, -206, -218, -363, -489, -491, and -596 [39]. …”
Section: Role Of Mirna In Oropharynx Tumorsmentioning
confidence: 99%
“…Появляются доказа-тельства того, что дисрегуляция микроРНК вследствие генетических мутаций, эпигенетических изменений, модификаций в биогегенезе, экспрессии поврежден-ного транскрипционного фактора или изменений в таргетных сайтах может приводить к прогрессии опухоли. В нескольких исследованиях установлены микроРНК при ПРГШ, которые представлены онко-генными транскриптами и супрессорами опухолевого роста [37]. К примеру, miR-130b гиперактивна при ПРГШ, что играет роль в эпителиально-мезенхималь-ном переходе [38,39].…”
Section: внутриопухолевая гетерогенностьunclassified
“…Several miRNAs have been found to be up or downregulated in OSCC [52]. A molecular classification of OSCC based on 61 miRNAs with an accuracy of 93% was achieved [53].…”
Section: Introductionmentioning
confidence: 99%