MicroRNAs and their role on fish oxidative stress during xenobiotic environmental exposures

Burgos-Aceves, Mario Alberto; Cohen, Amit; Smith, Yoav; Faggio, Caterina

doi:10.1016/j.ecoenv.2017.12.001

Cited by 216 publications

(54 citation statements)

References 102 publications

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“…Erythrocyte MN test in fish has been widely applied for in situ genotoxicity assessment of freshwater environments using native or laboratory manipulated animals following different periods of exposure (Barbee et al, ; De Lemos et al, ; Ergene, Cavas, Celik, Koleli, & Aymak, ; Marlasca et al, ; Moraes de Andrade et al, ; Rodrigues‐Cea, Ayllon, & Garcia‐Vasquez, ; Russo, Rocco, Moreascalchi, & Stingo, ). The MN test in fish erythrocytes was also widely validated for laboratory testing with different species after exposure to a large number of genotoxic agents (Bolognesi & Hayashi, ; Burgos‐Aceves, Cohen, Smith, & Faggio, ; Fazio et al, ; Fazio et al, ; Fazio et al, ; Faggio, Fazio, Marafioti, Piccione, & Arfuso, ). Responses were observed to a large number of experimental carcinogens, such as aflatoxins, methylcholanthrene, chlorinated hydrocarbons, PAHs (Al‐Sabti, ), cyclophosphamide (Ayllon & Garcia‐Vaszquez, ), pesticides (Ali, Nagpure, Kumar, Kumar, & Kushwaha, ), heavy metals (Al‐Sabti, ; Bolognesi, Perrone, Roggieri, Pampanin, & Sciutto, ) and ubiquitous environmental contaminants, for example, bisphenol A, tetrabromodiphenyl ether (Bolognesi et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Presence of erythrocyte with alteration nuclear morphology was reported also by other authors as physiologic conditions (Arikan, Goçmen, Atatur, Kumlutas, & Çiçek, 2009;Claver & Quaglia, 2009;Mayer, Knoll, Innis, & Mitchell, 2005), or induced by urban or industrial pollutant such as petrochemical products (Barbee et al, 2008;Marlasca, Sanpera, Riva, Sala, & Crespo, 1998) Erythrocyte MN test in fish has been widely applied for in situ genotoxicity assessment of freshwater environments using native or laboratory manipulated animals following different periods of exposure (Barbee et al, 2008;De Lemos et al, 2008;Ergene, Cavas, Celik, Koleli, & Aymak, 2007;Marlasca et al, 1998;Moraes de Andrade et al, 2004;Rodrigues-Cea, Ayllon, & Garcia-Vasquez, 2003;Russo, Rocco, Moreascalchi, & Stingo, 2004). The MN test in fish erythrocytes was also widely validated for laboratory testing with different species after exposure to a large number of genotoxic agents (Bolognesi & Hayashi, 2011;Burgos-Aceves, Cohen, Smith, & Faggio, 2018;Fazio et al, 2012; 2006). Interestingly, we found that the percentage of MN and nuclear abnormalities were increased, and these parameters correlate between them (their means differ nonsignificantly (Table 2).…”

Section: Discussionmentioning

confidence: 99%

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Digital light microscopy as a tool in toxicological evaluation of fish erythrocyte morphological abnormalities

Sula

Aliko

Pagano

et al. 2019

Microscopy Res & Technique

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Fish erythrocytes are very sensitive to environmental pollution because they exhibit pathological alterations before appearance of other external symptoms, may be used as reliable toxicity bioindicators. Microscopic analysis can be a useful tool in early detection of alterations in erythrocyte morphology due to different environmental stressors, and in predicting organism's possible response ways. This study aims to evaluate the toxicity of a polluted freshwater lake on the erythrocytes of crucian carp fish, Carassius carassius, using digital light microscopy (DLM). Scanning DLM micrographs revealed the presence of nuclear and cytoplasmic abnormalities like micronucleus, nuclear buds, lobed nucleus, deformed nucleus, vacuolated cytoplasm, and echinocyte in the erythrocytes of crucian carp fish from a polluted lake. The obtained results substantiate that computation of erythrocyte morphological damages as biomarkers of exposure, through digital light microscopy software, can be effectively used as a toxicological tool.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Digital light microscopy as a tool in toxicological evaluation of fish erythrocyte morphological abnormalities

Sula

Aliko

Pagano

et al. 2019

Microscopy Res & Technique

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“…This antioxidant system includes enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) or glutathione reductase (GR) and low‐molecular‐weight molecules, such as glutathione (GSH; Aliko, Qirjo, Sula, Morina, & Faggio, ; Capo et al, ; Freitas et al, ; Sureda et al, ). ROS overproduction can alter the balance between prooxidants and antioxidants, and this fact causes oxidative stress (Burgos‐Aceves, Cohen, Smith, & Faggio, ; Gobi, Vaseeharan, Rekha, Vijayakumar, & Faggio, ).…”

Section: Introductionmentioning

confidence: 99%

Perkinsus mediterraneus infection induces oxidative stress in the mollusc Mimachlamys varia

Box

Capó

Tejada

et al. 2019

Journal of Fish Diseases

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Perkinsus mediterraneus is a protozoan parasite that can cause marine mollusc diseases known as perkinsosis being a serious threat for clam cultures worldwide. The aim of the present study was first to determine the Perkinsus species infecting the variegated scallop Mimachlamys varia and then to evaluate the existence of oxidative stress in gills of M. varia according to different degrees of infection. DNA sequencing confirmed that P. mediterraneus was the species infecting M. varia. ROS production was progressively increasing with the degree of infection although the differences were only significant in the high‐infected group. Low degree of infection significantly increased superoxide dismutase (SOD) and glutathione S‐transferase (GST) activities and nitrite levels with respect to the control group. In the high‐infected group, a significant increase was evidenced in all analysed enzymes, catalase, SOD, glutathione reductase and GST. Non‐significant differences in MDA levels were observed between the control and low‐infected groups; however, a significant increase in MDA levels was observed in the high‐infected group. In conclusion, the infection by Perkinsus mediterraneus in M. varia induces oxidative stress and an antioxidant response directly related to the infection degree that can contribute to the pathogenicity of the infection.

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“…Fish usually used as a model animal in toxicology studies (Burgos‐Aceves, Cohen, Smith, & Faggio, ). Moreover, carps are an important family fish in aquaculture (Fiorino et al, ; Chromcova et al, ).…”

Section: Introductionmentioning

confidence: 99%

Histopathological lesions and toxicity in common carp (Cyprinus carpio L. 1758) induced by copper nanoparticles

Vajargah

Yalsuyi

Hedayati

et al. 2018

Microscopy Res & Technique

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105

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Different types of metal oxide nanoparticles (NPs) have been suggested for various applications such as water treatment and construction of agricultural pesticides; however, there are concerns about the potential toxicity of these compounds for the nontarget organism especially aquatic organisms. The aims of this study were assessing toxicity and histopathological effects of copper oxide NPs (NPs-CuO) on common carp (Cyprinus carpio) as a model organism. For this purpose 150 common carp with an average weight 7 ± 1 g were exposed to 0, 10, 20, 30, 40, 60, 80, 100, 150, and 200 mg/l of CuO-NPs (10 treatment with three replicates) for 96 hrs. After 24, 48, 72, and 96 hrs exposures, mortality rates recorded and gill samples were collected. Statistical analysis showed significant differences in carp survival between control and treatment groups (p < 0.05); regression between fish mortality rate and NPs-CuO concentration was also revealed (p < 0.01). The LC 96h of NPs-CuO for common carp was estimated as 124.9 mg/l in this study. Various tissue damages were observed in gill of treatments; such as, hypertrophy, hyperplasia, lamellar fusions, erythrocyte infiltration, epithelial lifting; also, there was significant correlation between intensity of tissue lesions and concentration of NPs-CuO (p < 0.01). The findings of the present study demonstrate that sublethal concentration of NPs-CuO can lead to serious tissue lesions. Whats more, concentrations above 30 ml/l of NPs-CuO can lead to some clinical signs; such as skin darkening and death with open mouth as well as definite fish death.

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MicroRNAs and their role on fish oxidative stress during xenobiotic environmental exposures

Cited by 216 publications

References 102 publications

Digital light microscopy as a tool in toxicological evaluation of fish erythrocyte morphological abnormalities

Digital light microscopy as a tool in toxicological evaluation of fish erythrocyte morphological abnormalities

Perkinsus mediterraneus infection induces oxidative stress in the mollusc Mimachlamys varia

Histopathological lesions and toxicity in common carp (Cyprinus carpio L. 1758) induced by copper nanoparticles

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