2010
DOI: 10.1254/jphs.10r11fm
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MicroRNAs and Their Therapeutic Potential for Human Diseases: Aberrant MicroRNA Expression in Alzheimer’s Disease Brains

Abstract: Abstract. MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled manner. They play a key role in neuronal development, differentiation, and synaptic plasticity. However, at present, the pathological implications of deregulated miRNA expression in neur… Show more

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Cited by 57 publications
(40 citation statements)
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“…n = 3, mean ± s.d., *p < 0.05, Student's t test translation [36]. It is therefore not surprising that dysregulation of miRNAs has been recently implicated in neurodegenerative disorders [19,21], including AD [20,22]. Altered expression of several miRNAs has been found in AD brains, a relevant number of which have been involved in the regulation of genes with a key role in AD pathogenesis, notably APP and BACE1 (reviewed in [22]).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…n = 3, mean ± s.d., *p < 0.05, Student's t test translation [36]. It is therefore not surprising that dysregulation of miRNAs has been recently implicated in neurodegenerative disorders [19,21], including AD [20,22]. Altered expression of several miRNAs has been found in AD brains, a relevant number of which have been involved in the regulation of genes with a key role in AD pathogenesis, notably APP and BACE1 (reviewed in [22]).…”
Section: Discussionmentioning
confidence: 99%
“…MiRNAs are small regulatory RNAs with established roles in neurodevelopment, neuroplasticity, apoptosis, and other neurobiological processes [17,18]. Accumulating evidence implicates miRNAs in the pathogenesis of neurodegenerative diseases, particularly AD [19][20][21][22].…”
Section: Introductionmentioning
confidence: 99%
“…MicroRNAs are important for brain function and neuronal survival. 57,58 Knockout of Dicer, which is responsible for microRNA processing, in dopaminergic neurons leads to cell death and reduced locomotion. 59 Dicer knockout in the hippocampus, Purkinje cells or striatum caused neuronal phenotypes with reduction of dendritic branches and size and increase of degeneration in respective brain areas.…”
Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning
confidence: 99%
“…Human brain cells and tissues utilize only a fraction of the ~900 currently known human miRNAs, and only a highly selective subset of these is altered in neurodegenerative disorders, such as Alzheimer’s disease (AD) [2,3,510]. Specifically, increases in the expression of miRNA-146a significantly regulate the abundance of two of miRNA-146a’s major targets, complement factor H (CFH) and interleukin-1 receptor associated kinase (IRAK) mRNAs, key modulators of the brain’s innate immune and inflammatory response [811].…”
mentioning
confidence: 99%