microRNAs are important players in head and neck carcinoma: A review

Janiszewska, Joanna; Szaumkessel, Marcin; Szyfter, Krzysztof

doi:10.1016/j.critrevonc.2013.07.012

Cited by 27 publications

(20 citation statements)

References 96 publications

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“…[155][156][157][158][159] MicroRNAs THAT REGULATE HNSCC INVASION MicroRNAs (miRNAs) are a class of gene-expression regulators that often have altered expression in various human cancers, including HNSCC. [160][161][162][163][164][165] The MiRNAs have emerged as having key roles in diverse cellular processes, including cancer cell proliferation, migration, invasion, and metastasis. 160,161,166,167 Dicer, a key enzyme involved in siRNA and miRNA function, was reduced in expression in tongue squamous cell carcinoma lines, and reduction of Dicer led to increased cell proliferation and invasion.…”

mentioning

confidence: 99%

Mechanisms of Invasion in Head and Neck Cancer

Jimenez¹,

Jayakar²,

Ow³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The highly invasive properties demonstrated by head and neck squamous cell carcinoma (HNSCC) are often associated with locoregional recurrence and lymph node metastasis in patients and is a key factor leading to an expected 5-year survival rate of approximately 50% for patients with advanced disease. It is important to understand the features and mediators of HNSCC invasion so that new treatment approaches can be developed.Objectives.-To provide an overview of the characteristics, mediators, and mechanisms of HNSCC invasion.Data Sources.-A literature review of peer-reviewed articles in PubMed on HNSCC invasion.Conclusions.-Histologic features of HNSCC tumors can help predict prognosis and influence clinical treatment decisions. Cell surface receptors, signaling pathways, proteases, invadopodia function, epithelial-mesenchymal transition, microRNAs, and tumor microenvironment are all involved in the regulation of the invasive behavior of HNSCC cells. Identifying effective HNSCC invasion inhibitors has the potential to improve outcomes for patients by reducing the rate of spread and increasing responsiveness to chemoradiation.

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mentioning

confidence: 99%

Mechanisms of Invasion in Head and Neck Cancer

Jimenez¹,

Jayakar²,

Ow³

et al. 2015

Archives of Pathology &Amp; Laboratory Medicine

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“…Altered expression of specific miRNAs has been associated with initiation or prognosis in a number of human cancers, and functional studies performed in cancer cell lines, or mouse models, involving over-expression or knockdown of miRNAs, have supported a role for miRNAs in carcinogenesis [19,22]. It is estimated that over 2,000 miRNAs exist in the human genome, although many of these have not yet been discovered [20].…”

Section: Microrna Characteristics and Biogenesismentioning

confidence: 99%

“…They are short (18-25 nucleotide), regulatory, non-coding single strands of RNA, which have diverse roles in cellular functions, including development, differentiation, proliferation, inflammation, immune responses, stress responses, and apoptosis [20,21]. miRNAs were initially linked to human cancers because of their proximity to chromosomal breakpoints or areas of instability, and dysregulated ex- pression levels in several human cancers [19].…”

Section: Microrna Characteristics and Biogenesismentioning

confidence: 99%

An Update on Cellular MicroRNA Expression in Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma

Emmett

Whiteman²,

Panizza

et al. 2018

Oncology

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Squamous cell carcinoma of mucosal sites in the head and neck (HNSCC) is the sixth most common cause of cancer worldwide, and despite advances in conventional management, it still has significant morbidity and mortality associated with both diagnosis and treatment. Advances in our understanding of the biological mechanisms underlying this disease have demonstrated a significant difference between human papillomavirus (HPV)-associated, HPV and tobacco associated, and HPV-negative disease. It remains important to further elucidate the biologic and genetic differences between HPV-associated and tobacco-associated disease, with the aim of earlier diagnosis through screening, and advances in management including the development of novel therapeutic agents. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression, and have effects on almost every cellular function, and have potentially important applications to diagnosis, management and prognosis in HNSCC. Establishing a cellular miRNA expression profile for HPV-associated disease may therefore have important implications for the screening and treatment of this disease. This review summarises the current findings regarding miRNA expression in mucosal HNSCC, and focuses particularly on miRNA expression in HPV-associated tumours.

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“…In addition, the miRNA tumor profile differed between each anatomic site, allowing its potential identification through tissue obtained from the nodal metastasis [51]. Approximately 10-20% of HNSCC patients have occult metastasis to cervical lymph nodes at diagnosis, and this is one of the strongest predictors of prognosis [32,65]. Using the differential expression of miR-205 between HNSCC and normal tissue, Fletcher et al were able to distinguish between benign lymph nodes and metastatic SCC to cervical lymph nodes [65].…”

Section: Associations With Survival and Prognosismentioning

confidence: 99%

“…They are short (18-25 nucleotide), regulatory, non-coding single strands of RNA, which have diverse roles in cellular functions, including: development, differentiation, proliferation, inflammation, immune responses, stress responses, and apoptosis [32,33]. MiRNAs were initially linked to human cancers because of their proximity to chromosomal breakpoints or areas of instability, and dysregulated expression levels in several human cancers [31].…”

Section: Introductionmentioning

confidence: 99%

Evaluating cellular microRNA expression in human papillomavirus associated head and neck squamous cell carcinoma

Emmett¹

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Squamous cell carcinoma of mucosal head and neck sites (HNSCC) is the sixth most common cause of cancer world-wide, and is associated with a significant morbidity and mortality despite advances in therapeutic options over the past decades. HNSCC includes tumours of the oral cavity, oropharynx, larynx and hypopharynx. While there has been a decline in tumours occurring as a result of exposure to the traditional risk factors of tobacco smoking and alcohol consumption, a significant increase has been observed in the number of tumours attributed to the Human Papillomavirus (HPV). This has primarily been associated with causation of tumours in the oropharynx, however, a smaller number of tumours at other subsites are also likely to be related to the virus. Although HPV-related tumours tend to have an improved prognosis and a better response to chemo-and radiotherapy, the pathobiology underlying these differences is not yet fully understood.MiRNAs are short, non-coding single strands of RNA which regulate gene expression at the posttranscriptional level. They have been identified to be dysregulated and function as tumour suppressor or oncogenes in a number of human cancers, including head and neck cancers. MiRNAs have also been associated with prognostication including associations with recurrence of disease and diseasefree survival. As they are readily available across a range of body tissues including solid tissue, saliva, and plasma, these biomarkers have potential utility in relation to screening for disease diagnosis, recurrence or progression. Although there is an established difference between HPV-positive and negative tumours in the oropharynx clinically, the majority of studies investigating miRNA expression in HNSCC have not taken this factor into account. In the small number of studies which have examined the effect of HPV on miRNA expression in HNSCC, there is a lack of consistency in the results described.This thesis aimed to assess the difference in miRNA expression between HPV-positive and negative tumours, through use of miRNA microarray followed by validation with real-time PCR using TaqMan assays combined with a sensitive detection method (Fluidigm HD) in a larger cohort of patients. It also investigated differences in miRNA expression in association with lifestyle factors, demographics and clinical outcomes. A set of seven miRNAs was identified to be differentially expressed between HPV-positive and negative tumours in the oropharynx. No difference in miRNA expression was observed between the two tumour cohorts at other subsites in the head and neck.Differences in miRNA expression were also observed with lifestyle factors such as smoking status and alcohol consumption. Recurrence of the primary tumour and overall disease-free survival were further associated with altered miRNA expression. The findings outlined in this thesis add to the present literature regarding differences in miRNA expression between HPV-positive and negative iii tumours in the oropharynx, and provide a basis for further...

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microRNAs are important players in head and neck carcinoma: A review

Cited by 27 publications

References 96 publications

Mechanisms of Invasion in Head and Neck Cancer

Mechanisms of Invasion in Head and Neck Cancer

An Update on Cellular MicroRNA Expression in Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma

Evaluating cellular microRNA expression in human papillomavirus associated head and neck squamous cell carcinoma

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