MicroRNAs as potential biomarkers in diseases and toxicology

Siddeek, Bénazir; Inoubli, Lilia; Lakhdari, Nadjem; Rachel, Paul Bellon; Fussell, Karma C.; Schneider, Steffen; Mauduit, Claire; Benahmed, Mohamed

doi:10.1016/j.mrgentox.2014.01.010

Cited by 53 publications

(37 citation statements)

References 176 publications

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“…117,118 Altered miRNA expression profiles have been reported for immune disorders such as rheumatoid arthritis 119 and systemic lupus erythematosus 120 as well as for pain conditions such as irritable bowel syndrome, 121 chronic bladder syndrome, 122 and endometriosis. 123 Cerebrospinal fluid from fibromyalgia patients showed differential expression of nine miRNAs and miR-145-5p correlated positively with pain ratings based on the fibromyalgia impact questionnaire 124 (Fig.…”

Section: Mirnas and Painmentioning

confidence: 99%

MicroRNA Biology and Pain

McDonald

Ajit

2015

Progress in Molecular Biology and Translational Science

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Section: Mirnas and Painmentioning

confidence: 99%

MicroRNA Biology and Pain

McDonald

Ajit

2015

Progress in Molecular Biology and Translational Science

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“…They have been indicated intargeting around 60% of human genes and regulated a range of biological processes, such as TGF-β and SIRT-1 signaling, Fas/FasL apoptotic pathways, and NF-κB pathway [6]. Moreover, miRNAs are associated with apoptosis, cell maturation, oxidative stress, degradation of extracellular matrix (ECM), angiogenesis, and inflammation [7] [8] [9] [10].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA Let-7g and Atherosclerosis Plaque Stabilization

Yin¹,

Zhang²,

Hou³

et al. 2017

WJCD

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Vascular atherosclerotic vulnerable plaque rupture is the primary cause of acute myocardial infarctions and strokes. Thus, stabilization of vulnerable plaques is of important clinical endeavor to decrease the fatal risk of atherosclerosis. Inflammatory infiltration, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells (VSMCs), destruction of extracellular matrix (ECM) or collagen, and neovascularization all contribute to the formation and stability of plaque. Let-7g, one miRNA of let-7 family, is related to retardation of the progress of vulnerable atherosclerosis plaque. First of all, let-7g induced preservation on vascular diseases through regulating on the intracellular Ca 2+ -activated protein kinase C-oxLDL-LOX-1 pathway, which resulted in reduced leukocyte adhesion to and migration across endothelium. Over expression of let-7g negatively regulated apoptosis in the ECs by targeting lectin-like oxidized LDL receptor-1(LOX-1)/CASP3 expression, therefore made the fibrous cap of plaque integrated and thick, increased the density of vascular atherosclerotic plaque. In addition, let-7g might stabilize the atherosclerotic plaque through other aspects. In this review, we focus on current and potential importance of let-7g on the stabilization of atherosclerosis plaque which might lead to the future development of an alternative strategy of CAD.

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“…8) We were interested in the effects of nuclear receptor ligands, since some nuclear receptors, such as pregnane X receptor (PXR) and constitutive androstane receptor (CAR), are indispensable for the expression of drug metabolizing enzymes, especially the CYPs. Recently, Takahashi et al showed that rifampicin, a PXR ligand, alters the expression of miR-34a and miR-148a in human hepatocytes.…”

mentioning

confidence: 99%

Identification of Candidate Target <i>Cyp</i> Genes for microRNAs Whose Expression Is Altered by PCN and TCPOBOP, Representative Ligands of PXR and CAR

Moriya

Kataoka

Nishikawa

et al. 2016

Biological & Pharmaceutical Bulletin

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MicroRNAs (miRNAs) are small non-coding RNAs that are involved in mRNA post-transcriptional regulation. The deregulation of miRNAs affects the expression of drug-metabolizing enzymes, drug transporters, and nuclear receptors, all of which are important in regulating drug metabolism. miRNA expression can be altered by several endogenous or exogenous agents, such as steroid hormones, carcinogens, and therapeutic drugs. However, it is unclear whether hepatic miRNA expression is regulated by nuclear receptors, such as pregnane X receptor (PXR) and constitutive androstane receptor (CAR), which are indispensable for the expression of the CYPs. Here we investigated the effects of the mouse PXR and CAR ligands pregnenolone-16α-carbonitrile (PCN) and 1,4-bis[(3,5-dichloropyridin-2-yl)oxy]benzene (TCPOBOP) on hepatic miRNA expression in mice. We found that the expression of 9 miRNAs was increased (>2-fold) and of 4 miRNAs was decreased (>50%) in response to PCN, while TCPOBOP treatment led to the up-regulation of 8 miRNAs and down-regulation of 6 miRNAs. Using several miRNA target prediction algorithms, we found that the predicted target genes included several lesser known Cyp genes (Cyp1a1, Cyp1b1, Cyp2b10, Cyp2c38, Cyp2u1, Cyp4a12a/b, Cyp4v3, Cyp17a1, Cyp39a1, and Cyp51). We analyzed the expression of these genes in response to PCN and TCPOBOP and found changes in their mRNA levels, some of which were negatively correlated with the expression of their corresponding miRNAs, suggesting that miRNAs may play a role in regulating Cyp enzyme expression. Further studies will be required to fully elucidate the miRNA regulatory mechanisms that contribute to modulating CYP expression.Key words microRNA; cytochrome P450; nuclear receptor; pregnane X receptor (PXR); constitutive androstane receptor (CAR) MicroRNAs (miRNAs) are a class of small non-coding RNAs that act as post-transcriptional gene expression regulators. They bind to the 3′-untranslated region (3′UTR) of target mRNA(s) with incomplete complementarity, and induce mRNA degradation or translational repression. 1) Each miRNA has the potential to regulate hundreds of target mRNAs, and each mRNA can be targeted by multiple miRNAs. Thus, miRNAs are believed to establish highly complex gene regulatory networks, and accumulating evidence indicates that they are involved in regulating various biological processes, including proliferation, differentiation, and development.2) miRNAs are also important in modulating drug metabolism through the regulation of drug-metabolizing enzymes, transporters, and nuclear receptors.3) Using in silico bioinformatical tools (e.g., miRanda, PITA, and Targetscan), Singh et al. predicted that the CYP genes are targeted by miRNAs. 4)Some of these predictions have subsequently been confirmed experimentally. For example, Pan et al. revealed that miR-27b and mmu-miR-298 directly target CYP3A4, 5) which metabolizes more than 50% of therapeutic drugs. Other studies have shown that other Cyp enzymes are regulated by miRNAs. 6,7)These findings strongly su...

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MicroRNAs as potential biomarkers in diseases and toxicology

Cited by 53 publications

References 176 publications

MicroRNA Biology and Pain

MicroRNA Biology and Pain

MicroRNA Let-7g and Atherosclerosis Plaque Stabilization

Identification of Candidate Target <i>Cyp</i> Genes for microRNAs Whose Expression Is Altered by PCN and TCPOBOP, Representative Ligands of PXR and CAR

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