MicroRNAs as potential cancer therapeutics

Trang, Phong; Weidhaas, Joanne B.; Slack, Frank J.

doi:10.1038/onc.2009.353

Cited by 194 publications

(154 citation statements)

References 66 publications

(78 reference statements)

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“…On account of the involvement of miRNA in eukaryotic cell function, the dysregulation of miRNA is correlated with disease (10) and cancer (11). Notably, miRNA-based therapies have been reported to be a potential for cancer treatment (12). miR-766-5p has been demonstrated to be overexpressed in CRC and promote the cell proliferation of SW480 cells (13).…”

Section: Introductionmentioning

confidence: 99%

The role of miR-766-5p in cell migration and invasion in colorectal cancer

2018

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Abstract. Colorectal cancer (CRC) develops from the colon or rectum and is the fourth highest inducer of cancer mortality. In the present study, cancer tissues and normal tissues were extracted from patients with CRC who were treated in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Jinan, China). Reverse transcription-quantitative polymerase chain reaction demonstrated that the expression level of miR-766-5p was significantly higher (P<0.01) in cancer tissue than that in normal tissue. SW480 cells were used for in vitro study and randomly separated into the miR-negative control (NC) inhibitor treatment group and miR-766-5p inhibitor treatment group. SW480 cell behaviors were evaluated. Results demonstrated that in the miR-766-5p inhibitor group, there was a decreased level of cell proliferation/migration/invasion and higher cell apoptosis compared with that in the miR-NC inhibitor group. miR-766-5p was predicted and verified to target the 3' untranslated region of suppressor of cancer cell invasion (SCAI) in SW480 cells. Protein expression levels of matrix metalloproteinase-2/phosphoinositide 3-kinase/AKT were decreased and SCAI was increased following miR-766-5p inhibitor treatment. In conclusion, the present study indicated that miR-766-5p inhibitor repressed the process of CRC by targeting SCAI.

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Section: Introductionmentioning

confidence: 99%

The role of miR-766-5p in cell migration and invasion in colorectal cancer

2018

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“…Expression of particular miRNAs has been found to be tissue-, developmental-, and even diseasespecific, revolutionizing our understanding of gene expression regulatory networks. Recent studies have shown that miRNAs function as key mediators in multiple normal and disease-related biological processes (11)(12)(13)(14)(15). Consequently, novel therapeutical approaches that exploit miRNA-dependent gene silencing offer promising approaches for the management of multiple diseases.…”

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confidence: 99%

“…1B). To test the hypothesis that Srebp-2 and miR-33 are coexpressed and regulated by the same metabolic/sterol stimuli, we incubated mouse and human primary macrophages in media containing low or high sterols (see Materials and Methods), conditions known to regulate Srebp-2, SREBP-2 target genes, and LXR target genes (7)(8)(9)(10)(11)(12)(13)(14)(15)(16). As expected, excessive exogenous cholesterol resulted in increased expression of the LXR target gene Abca1, with concomitant repression of the SREBP-2 target Ldl-r, whereas the opposite pattern of gene expression was found in cells incubated in media lacking cholesterol ( Fig.…”

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confidence: 99%

miR-33 links SREBP-2 induction to repression of sterol transporters

Marquart

Allen

Ory

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

505

501

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The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR) control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and synthesis, and cholesterol efflux, respectively. The clinical importance of SREBP-2 is revealed in patients with hypercholesterolemia treated with statins, which reduce low-density lipoprotein (LDL) cholesterol levels by increasing hepatic expression of SREBP-2 and its target, the LDL receptor. Here we show that miR-33 is encoded within SREBP-2 and that both mRNAs are coexpressed. We also identify sequences in the 3′ UTR of ABCA1 and ABCG1, sterol transporter genes both previously shown to be regulated by LXR, as targets for miR-33-mediated silencing. Our data show that LXR-dependent cholesterol efflux to both ApoAI and serum is ameliorated by miR-33 overexpression and, conversely, stimulated by miR-33 silencing. Finally, we show that ABCA1 mRNA and protein and plasma HDL levels decline after hepatic overexpression of miR-33, whereas they increase after hepatic miR-33 silencing. These results suggest novel ways to manage hypercholesterolemic patients.

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“…miRNAs are endogenous short non-coding molecules able to regulate gene expression at the post-transcriptional level (7). In the last decade, miRNAs, a new class of molecules able to post-transcriptionally regulate gene expression, have emerged to be involved in several fundamental physiological and pathological biomolecular and cellular mechanisms (8,9). miRNA profiles have been analyzed and several differentially expressed miRNAs involved in many cellular functions such as apoptosis, cell cycle control, and DNA damage/repair were identified in response to different radiation doses (10).…”

Section: Introductionmentioning

confidence: 99%

Knockdown of microRNA-1323 restores sensitivity to radiation by suppression of PRKDC activity in radiation-resistant lung cancer cells

Han

et al. 2015

Oncology Reports

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Abstract.Resistance to radiation is a major problem in cancer treatment. The mechanisms of radioresistance remain poorly understood; however, mounting evidence supports a role for microRNAs (miRNAs) in the modulation of key cellular pathways mediating the response to radiation. The present study aimed to identify specific miRNAs and their effect on radioresistant cells. The global miRNA profile of an established radioresistant lung cancer cell line and the corresponding control cells was determined.

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MicroRNAs as potential cancer therapeutics

Cited by 194 publications

References 66 publications

The role of miR-766-5p in cell migration and invasion in colorectal cancer

The role of miR-766-5p in cell migration and invasion in colorectal cancer

miR-33 links SREBP-2 induction to repression of sterol transporters

Knockdown of microRNA-1323 restores sensitivity to radiation by suppression of PRKDC activity in radiation-resistant lung cancer cells

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