MicroRNAs as prognostic molecular signatures in renal cell carcinoma: a systematic review and meta-analysis

Gu, Liangyou; Li, Hongzhao; Chen, Luyao; Ma, Xin; Gao, Yu; Li, Xintao; Zhang, Yu; Yang, Fan; Zhang, Xu

doi:10.18632/oncotarget.5324

Cited by 95 publications

(94 citation statements)

References 77 publications

(110 reference statements)

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“…As RCC is the most common type of kidney cancer, with an increasing incidence (7,24), it is important to explore and understand the tumor biology of this malignancy in order to find new early diagnostic markers and therapeutic approaches. Cancer cells aquire various mechanisms by which they escape apoptosis, become immortal, or provide to them at least a survival advantage compared to non-malignant cells (25).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, it is more necessary than ever to understand its tumor biology and explore new targets for further therapeutic approaches and prognostic options (6). Former studies suggested that among others, a misguided microRNA expression pattern may be involved in tumor initiation and progression in RCC (7,8). Among such mechanisms, small regulatory RNAs, so-called microRNAs (miRs), can operate as controllers of different proccesses in tumorigenesis, such as cell migration and differentiation, as well as metastasis and apoptosis (9-11).…”

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confidence: 99%

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MicroRNA-1 and MicroRNA-21 Individually Regulate Cellular Growth of Non-malignant and Malignant Renal Cells

Ahrend

Kaul

Ziegler

et al. 2017

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Abstract. Background/Aim: Due to its poor prognosis, it is increasingly necessary to understand the biology of renal cell cancer (RCC). Therefore, we investigated the role of microRNAs miR-1 and miR-21 in the growth of RCC cells compared to that of non-malignant renal cells. Materials and Methods: Four malignant cell lines RCC4, A498) Tumorigenesis gives cells an advantage in survival by an increase of proliferation, angiogenesis, immunomodulation and immortality (1-4). Due to its delayed diagnosis until advanced stages, renal cell cancer (RCC) is known as the deadliest neoplasm of the urinary tract (1, 5). Thus, it is more necessary than ever to understand its tumor biology and explore new targets for further therapeutic approaches and prognostic options (6). Former studies suggested that among others, a misguided microRNA expression pattern may be involved in tumor initiation and progression in RCC (7,8). Among such mechanisms, small regulatory RNAs, so-called microRNAs (miRs), can operate as controllers of different proccesses in tumorigenesis, such as cell migration and differentiation, as well as metastasis and apoptosis (9-11). miR-1 and miR-21 are two of numerous representatives of microRNAs. miR-1, initially found in cardiac muscle cells (12), but also found in various tissues (13-15), was strongly suspected of acting as a tumor suppressor due to its antioncogenic properties (16) in prostate, breast and colorectal cancer (13-15); interestingly, the type of tissue in fact determines the biological behavior of miR-1 (9). Sadly, the current data situation for the expression of miR-1 in RCC leaves much to be desired. For this reason, our study aimed to expand the first findings in order to gain a better understanding of the tumor biology of RCC. Similarly to miR-1, miR-21 was also detected in various malignant tissues, such as prostate and lung cancer and their metastases, pancreatic cancer and colorectal cancer (17-21). However, in contrast to miR-1, miR-21 appears to be an oncomir. There are preliminary investigations, showing miR-21 to appear as an oncomir in the case of RCC (22, 23).The fact that cancer cells have a further survival advantage by extending their chromosomal ends by means of endogenic telomerase, not only raises a problem, but also provides a therapeutic approach in cancer therapy (4).In order to gain deeper insight into these issues, as far as we are aware, we are the first to investigate one non-malignant 625 This article is freely accessible online. *These Authors contributed equally to this study. Materials and MethodsCell culture. Human RCC cell lines Caki-1, 786-O, A498 (all Cell Lines Service, Eppelheim, Germany), and RCC4 (Sigma-Aldrich, München, Germany) and the non-malignant renal cell line RC-124 (Cell Lines Service) were applied in this study. Caki-1 and A498 cells were propagated in minimum essential medium (MEM) supplemented with 79.6 mg/l non-essential amino acids, 2 mM L-glutamine, 1 mM sodium pyruvate, 1% penicillline/streptomycin (P/S), and 10% fetal bovine serum (FBS...

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

MicroRNA-1 and MicroRNA-21 Individually Regulate Cellular Growth of Non-malignant and Malignant Renal Cells

Ahrend

Kaul

Ziegler

et al. 2017

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“…RCC patients with positive microRNA-21 exhibit shorter disease-free and overall survival rates (13). Therefore, microRNA-21 is proposed as a diagnostic and prognostic marker in renal cell carcinoma (15,44,45). So, in this study influence of cordythat cordycepin dose-dependently down-regulated microRNA-21 levels in Caki-1 cells (Fig.…”

Section: Effects Of Cordycepin On Renal Cell Carcinoma Caki-1 Cellsmentioning

confidence: 62%

<b>Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN </b><b>phosphatase </b>

et al. 2017

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Cordycepin is an active component extracted from Traditional Chinese medical herb Cordyceps militaris. Many reports demonstrated that cordycepin harbors antitumor activity in a broad spectrum of cancer types. In this study the actions and the underneath molecular mechanisms of cordycepin were investigated in renal cell carcinoma Caki-1 cell line. Results showed that cordycepin induced apoptotic cell death and inhibited cell migration in Caki-1 cells. Quantitative real-time PCR results and western blot analyses indicated cordycepin dose-dependently decreased microRNA-21 expression and Akt phosphorylation levels in Caki-1 cells, but increased PTEN phosphatase levels. Block of cordycepin-induced microRNA-21 decrease or PTEN increase in Caki-1 cells by transfection of microRNA-21 mimic or PTEN siRNA significantly attenuated cordycepin-induced cell death and inhibition of cell migration. Taken together, findings in present study suggested that cordycepin induced apoptotic cell death in renal cell carcinoma through regulation of microRNA-21 and PTEN phosphatase. Furthermore, present study also firstly illustrated that cordycepin inhibited cell migration of renal cell carcinoma, which also involved micro-RNA-21 and PTEN phosphatase.Renal cell carcinoma (RCC) is the most lethal urological cancer, accounting for 87% of all renal malignancies and 2-3% of all cancers (4). In the past two decades, the global incidence of RCC has increased by 2% per year (4). Worldwide, the agestandardized incidence and mortality of RCC were 6 per 100,000 and 2.1 per 100,000 respectively (43). Despite advance in diagnostic techniques, up to 20-30% of patients with RCC present with metastasis (4). The prognosis of RCC has historically been poor, with 5-year survival rate of 8% among patients with metastatic RCC (9). Although recent progress about understanding of the pathogenesis of RCC has led to novel immune-based and targeted treatments for this chemoresistant cancer, no one drug obtains overall response rate of 100% and durable complete responses (4, 9). Development of neo-adjuvant therapy is still in a demand at present. Cordycepin is a main active composition extracted from Cordyceps militaris and has been reported to harbor anti-tumor activity in a broad spectrum of cancer types, including lung cancer (50), ovarian cancer (46), leukemia (30), breast cancer (47), and so on (33). Two recent reports firstly demonstrated that cordycepin could induce apoptosis in renal cell carcinoma through Erk-JNK signaling pathway (20,48) and indicated the potential application of cordycepin in treating renal cell carcinoma. However, the actions and the underneath molecular mechanisms of cordycepin in renal cell carcinoma are not definitely clear and warrant extensive and further investigations. Recently, a comprehensive molecular analysis

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“…Therefore, in this present study, we aimed to identify new miRNA biomarker that could be used as predictor for the overall survival of GC patients and also with the hope to reveal the underlying mechanism of how miRNA participated in the development of GC. miR-100 has been found aberrant expressed in several human cancers but its role in tumorigenesis is still controversial (16)(17)(18)(19)(20). The reason for that might be it can regulate different downstream target genes and therefore it can have different and even opposite functions in tumors.…”

Section: Discussionmentioning

confidence: 99%

“…For example, miR-100 was found to acting as tumor suppressor by deregulation its target genes in hepatocellular carcinoma (17), epithelial ovarian cancer (18), and breast cancer (19). However, miR-100 was also found to acting as oncogene in renal cell carcinoma (20) and acute myeloid leukemia (16). Therefore, the clinical significance of miR-100 in GC and the underlying mechanism still remained to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7

Cao

Song

et al. 2017

Oncol Lett

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MicroRNAs as prognostic molecular signatures in renal cell carcinoma: a systematic review and meta-analysis

Cited by 95 publications

References 77 publications

MicroRNA-1 and MicroRNA-21 Individually Regulate Cellular Growth of Non-malignant and Malignant Renal Cells

MicroRNA-1 and MicroRNA-21 Individually Regulate Cellular Growth of Non-malignant and Malignant Renal Cells

<b>Cordycepin induces apoptotic cell death and inhibits cell migration in renal cell carcinoma via regulation of microRNA-21 and PTEN </b><b>phosphatase </b>

MicroRNA-100 suppresses human gastric cancer cell proliferation by targeting CXCR7

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