MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

Stojković, Stefan; Nossent, A. Yaël; Haller, P; Jäger, Bernhard; Vargas, Kris G.; Wojta, Johann; Huber, Kurt

doi:10.1055/s-0039-1693702

Cited by 24 publications

(22 citation statements)

References 101 publications

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“…Recent several research groups evidenced that microRNAs have significant impact on various cardiovascular biology and progression of diseases including coronary artery disease (CAD) and atherothrombosis. MicroRNAs which are detectable in various body fluids are defined as circulating microRNAs [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging

Sheikh

2020

Cardiology Research and Practice

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The present study explored the clinical value of plasma microRNA-21 as a novel biomarker for early prediction of stable and unstable angina patients and its relationship with aging. A total of 255 participants, 123 patients with chronic stable angina, 82 patients with unstable angina, and 50 healthy subjects, were included in our study. Stable coronary and unstable coronary patients were confirmed following AHA/ACC clinical protocols. Total RNA was extracted from plasma by using miRNA-based TRIzol reagent. Plasma miR-21 expression levels were determined by real-time polymerase chain reaction. To evaluate the diagnosis accuracy, the receiver operating characteristic (ROC) curves were used. Plasma microRNA-21 concentration levels were significantly elevated in stable and unstable angina patients as compared with control subjects P<0.001. The area under the ROC curves of circulating microRNA-21 was accurately distinguished in stable angina patients (AUC 0.921) and unstable angina patients (AUC 0.944) from healthy subjects. MicroRNA-21 expression gradually elevated with increasing aging in all the populations. Moreover, the current study also demonstrated that the expression of plasma miR-21 levels was significantly associated with different age groups within healthy subjects and stable and unstable angina patients P<0.001. This research finding suggested that plasma microRNA-21 may be considered as a suitable new biomarker for early detection of stable and unstable angina patients, and it has a strong correlation with aging.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging

Sheikh

2020

Cardiology Research and Practice

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“…The first two papers 5,6 describe platelet function testing in hemostasis in arterial and venous thrombosis: the first on total antithrombotic effects of combination antithrombotic effects in various cardiovascular conditions, and the second on the role of platelet micro-ribonucleic acids in platelet function in stable and unstable coronary artery disease.…”

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confidence: 99%

Platelets: The Balance between Aggregation and Bleeding

Verheugt

2019

Thromb Haemost

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“…Кроме того, сама процедура ЧКВ активирует тромбоциты. Потому ДАТ уменьшает развитие периоперационного инфаркта миокарда (ИМ), снижает риск развития интраоперационного и острого тромбоза стента, снижает риски ишемических осложнений при ожидании пациентами операции КШ [3].…”

Section: доказательная база преимуществ раннего назначения дат при оксunclassified

Timing of dual antiplatelet therapy in acute coronary syndrome: a problem of coronary artery bypass grafting accessibility for patients

2020

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The feasibility of dual antiplatelet therapy as early as possible in patients with ST-segment elevation acute coronary syndrome, where percutaneous coronary intervention is recommended, has been proven: it improves treatment outcomes by reducing the risk of adverse ischemic events, including stent thrombosis and myocardial infarction.This article provides a detailed analysis of the evidence data and current recommendations on the validity and timing of dual antiplatelet therapy for acute coronary syndrome. The emphasis is made on the controversy regarding the early dual antiplatelet therapy in non-ST-segment elevation acute coronary syndrome. The rationale for using dual antiplatelet therapy only after coronary angiography and determining the revascularization strategy is described, which should increase the accessibility of coronary artery bypass graft surgery for patients.

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MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

Cited by 24 publications

References 101 publications

Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging

Diagnostic Role of Plasma MicroRNA-21 in Stable and Unstable Angina Patients and Association with Aging

Platelets: The Balance between Aggregation and Bleeding

Timing of dual antiplatelet therapy in acute coronary syndrome: a problem of coronary artery bypass grafting accessibility for patients

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