MicroRNAs as regulators of connexin-43 expression

Abstract

Posttranscriptional regulation of the biosynthesis of connexins, the building blocks of gap junctional channels, may occur by modulation of connexin mRNA stability and translation. To date, few RNA binding proteins and micro-RNAs (miRNAs) affecting connexin expression are known. In recent years, it has become clear that epigenetic processes are also essentially involved in connexin gene expression. In this review, we summarize recent knowledge on regulation of connexin expression by transcription factors and epigenetic mechanisms including microRNA.

Regulation of Connexins Expression Levels by MicroRNAs, an Update

“…Likewise, in glioblastoma multiforme, it was observed that downregulation of Cx43 by miR-221/222 is implicated in invasiveness and disease progression (Hao et al, 2012). The level of downregulation has been associated with the degree of malignancy (Hao et al, 2012; Ye et al, 2016). Therefore, when U251 human glioblastoma cells were transfected with antisense oligonucleotides against miR-221/222, Cx43 expression was upregulated, and cellular communication through GJCs was restored (Hao et al, 2012).…”