MicroRNAs Associated With HBV Infection And HBV-related HCC

Xie, Kunlin; Zhang, Yange; Li, Jun; Zeng, Yong; Wu, Hong

doi:10.7150/thno.8715

Cited by 72 publications

(83 citation statements)

References 153 publications

(154 reference statements)

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“…Therefore, the consequence of the inhibition of PTEN by miR21 is the activation of the PI3K/AKT pathway, which promotes cancer cell proliferation and metastasis (28). miR221/222 acts on many key tumor suppressors, including Bmf (29) (35). Among the HBV-related miRNAs, miR1 and miR501-5p can promote HBV replication, thereby promoting the occurrence and progression of HCC (36)(37)(38).…”

Section: Discussionmentioning

confidence: 99%

An Artificially Designed Interfering lncRNA Expressed by Oncolytic Adenovirus Competitively Consumes OncomiRs to Exert Antitumor Efficacy in Hepatocellular Carcinoma

Sun

et al. 2016

Molecular Cancer Therapeutics

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Endogenous miRNAs, especially oncogenic miRNAs (OncomiR), have been molecular targets for cancer therapy. We generated an artificially designed interfering long noncoding RNA (lncRNAi), which contains the sequences that can complementarily bind to multiple OncomiRs and is expressed by cancer-selectively replicating adenovirus. The adenovirus-expressed lncRNAi with high levels in hepatocellular carcinoma (HCC) cells competes with OncomiR target genes to bind to and consume OncomiRs, thereby achieving the targeted anti-HCC efficacy. With the targeting replication of adenovirus in HCC cells, lncRNAi was highly expressed and resulted in decreased abilities of proliferation, migration, and invasion, induced cell-cycle changes and apoptosis, and markedly changed the cellular mRNA and miRNA expression profiles in HCC cells. The optimal antitumor effect was also demonstrated on HCC cell line xenograft models and HCC patient-derived xenograft (PDX) tumor models in nude mice. This strategy has established a technology platform with a reliable therapeutic effect for HCC therapy.

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Section: Discussionmentioning

confidence: 99%

An Artificially Designed Interfering lncRNA Expressed by Oncolytic Adenovirus Competitively Consumes OncomiRs to Exert Antitumor Efficacy in Hepatocellular Carcinoma

Sun

et al. 2016

Molecular Cancer Therapeutics

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“…A previous study examined the effect of a family history of HCC on the incidence of HCC in the entire population who were screened for HBV seromarkers, and elucidated that family history of HCC multiplied the risk of HCC at each stage of HBV infection (7). Although numerous molecular studies have revealed that the HBV-encoded X (HBx) protein performs a critical role in hepatocarcinogenesis in patients with HBV-associated HCC (9)(10)(11)(12), the mechanisms underlying familial clustering-associated carcinogenesis remain to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection

Zhang

et al. 2017

Oncology Letters

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Abstract. Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression profiles of 3 patients with HCC with familial aggregation of HCC and HBV infection and 1 healthy volunteer were examined by microarray analysis, in order to identify relevant miRNAs involved in the pathogenesis of HCC with familial aggregation and HBV infection. The results indicated that 26 miRNAs exhibited a ≥20-fold increase or decrease in the plasma of patients with HCC, compared with the healthy control (24 upregulated and 2 downregulated). Among these altered miRNAs, 15 of them have been reported in HCC. The other 11 miRNAs have never been reported in HCC. These differentially-expressed miRNAs may be potential molecular markers for HCC pathogenesis and development.

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“…MicroRNAs (miRNAs) comprise a group of small noncoding RNAs which regulate gene expression at the posttranslational level, thereby participating in fundamental biological processes including cell proliferation, differentiation, and apoptosis (Karakatsanis et al, 2013;Wang et al, 2014a;Xie et al, 2014). miRNAs have been proposed to represent ideal biomarker candidates because of their resistance to endogenous RNase resistance and high stability under different storage conditions (Schwarzenbach et al, 2014) and in the peripheral blood (Zhu et al, 2012;Wang et al, 2014c).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

Yan

Liu

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The diagnostic and prognostic value of miR-21 has been examined for hepatocellular carcinoma (HCC), with inconsistent results. Present meta-analysis summarized the diagnostic accuracy and the predictive role for survival of miR-21 in patients with HCC. All eligible studies were searched using PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases up to October 2014. For the diagnostic meta-analysis, the indices of miR-21 in the diagnosis of HCC were pooled using bivariate random-effect approach models. For the prognostic meta-analysis, data were synthesized with a random effect model, and the hazard ratio (HR) or odd ratio (OR) with its 95% confidence interval (95%CI) was used as the effect size estimate. Ten studies dealing with HCC were included. The overall pooled results for sensitivity, specificity, and the area under the curve (AUC) for the diagnostic meta-analysis (five studies) were 74. The combined data for the prognostic meta-analysis (seven studies) suggested that miR-21 overexpression in HCC correlated with poor overall survival [HR = 1.19 (95%CI = 0.44-1.94)], and higher miR-21 expression was associated with tumor, node, metastases (TNM) stage [OR = 0.34 (95%CI = 0.13-0.91)]. We concluded that miR-21 might be complementary to alpha fetal protein in HCC diagnosis, and might serve as an attractive estimator of HCC. We also demonstrated that miR-21 overexpression was associated with HCC TNM stage and with poor survival. As our study was limited, additional prospective studies are needed to validate these results.

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MicroRNAs Associated With HBV Infection And HBV-related HCC

Cited by 72 publications

References 153 publications

An Artificially Designed Interfering lncRNA Expressed by Oncolytic Adenovirus Competitively Consumes OncomiRs to Exert Antitumor Efficacy in Hepatocellular Carcinoma

An Artificially Designed Interfering lncRNA Expressed by Oncolytic Adenovirus Competitively Consumes OncomiRs to Exert Antitumor Efficacy in Hepatocellular Carcinoma

MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection

Investigation of the value of miR-21 in the diagnosis of early stage HCC and its prognosis: a meta-analysis

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