MicroRNAs at the epicenter of intestinal homeostasis

Belcheva, A.

doi:10.1002/bies.201600200

Cited by 45 publications

(24 citation statements)

References 118 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another layer of regulatory complexity consists of post-transcriptional regulation involving microRNA (miRNA)–messenger RNA (mRNA) target interactions. In addition to specific miRNAs associated with intestinal homeostasis and permeability [ 14 – 17 ], miRNA–mRNA interactions result in competing-endogenous RNA (ceRNA) function. miRNAs may target multiple RNA transcripts, while an mRNA transcript may be targeted by multiple miRNAs (Fig.…”

Section: Introductionmentioning

confidence: 99%

Modelling the structure of a ceRNA-theoretical, bipartite microRNA–mRNA interaction network regulating intestinal epithelial cellular pathways using R programming

Robinson

Henderson

2018

BMC Res Notes

View full text Add to dashboard Cite

ObjectiveWe report a method using functional-molecular databases and network modelling to identify hypothetical mRNA–miRNA interaction networks regulating intestinal epithelial barrier function. The model forms a data-analysis component of our cell culture experiments, which produce RNA expression data from Nanostring Technologies nCounter® system. The epithelial tight-junction (TJ) and actin cytoskeleton interact as molecular components of the intestinal epithelial barrier. Upstream regulation of TJ-cytoskeleton interaction is effected by the Rac/Rock/Rho signaling pathway and other associated pathways which may be activated or suppressed by extracellular signaling from growth factors, hormones, and immune receptors. Pathway activations affect epithelial homeostasis, contributing to degradation of the epithelial barrier associated with osmotic dysregulation, inflammation, and tumor development. The complexity underlying miRNA–mRNA interaction networks represents a roadblock for prediction and validation of competing-endogenous RNA network function.ResultsWe developed a network model to identify hypothetical co-regulatory motifs in a miRNA–mRNA interaction network related to epithelial function. A mRNA–miRNA interaction list was generated using KEGG and miRWalk2.0 databases. R-code was developed to quantify and visualize inherent network structures. We identified a sub-network with a high number of shared, targeting miRNAs, of genes associated with cellular proliferation and cancer, including c-MYC and Cyclin D.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3126-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

Modelling the structure of a ceRNA-theoretical, bipartite microRNA–mRNA interaction network regulating intestinal epithelial cellular pathways using R programming

Robinson

Henderson

2018

BMC Res Notes

View full text Add to dashboard Cite

show abstract

“…Finally, as a prototypical HDACi, butyrate regulates the expression of many protein‐coding genes and also alters miRNA expression in many solid and nonsolid cancer cell lines as well as in the intestines. For instance, butyrate downregulates the expression of oncogenic miRNAs (miRs) (miR‐17‐92, miR‐106b‐25, and miR‐106a‐363 clusters) and upregulates the expression of miRNA suppressors (miR‐15a and miR‐16) (for review see Ali et al and Belcheva).…”

Section: Natural Compounds Possessing Epigenetic Properties That Stimmentioning

confidence: 99%

Anticancer potential of naturally occurring immunoepigenetic modulators: A promising avenue?

Schnekenburger

Dicato

Diederich

2019

Cancer

View full text Add to dashboard Cite

The immune system represents the major primary defense line against carcinogenesis and acts by identifying and eradicating nascent transformed cells. A growing body of evidence is indicating that aberrant epigenetic reprogramming plays a key role in tumor immune escape through: 1) impaired efficient recognition of neoplastic cells by the immune system, resulting from a downregulation or loss of the expression of tumor‐associated antigens, human leukocyte antigens, antigen processing and presenting machinery, and costimulatory molecule genes; 2) aberrant expression of immune checkpoint proteins and their ligands; and 3) modification of cytokine profiles and tumor‐associated immune cell populations toward an immunosuppressive state in the tumor microenvironment. Consistent with the inherent reversibility of epigenetic alterations, epigenetic drugs, including DNA methyltransferase and histone deacetylase inhibitors, have the unique potential to favorably modify the tumor microenvironment, restore tumor recognition and stimulate an antitumor immune response. The objective of this review is to highlight selected, naturally occurring epigenetic modulators, namely, butyrate, curcumin, (−)‐epigallocatechin‐3‐gallate, resveratrol, romidepsin, and trichostatin A, with a special focus on their antitumor immune properties.

show abstract

“…It has been found that microbiota-produced butyrate regulated hepatic cell apoptosis and proliferation by inducing miR-22 expression ( Pant et al, 2017 ). The research about gut microbiota–miRNA interaction has revealed that the gut microbiota could be regulated by host-secreted miRNAs and the gut microbiota may affect the host via inducing miRNAs ( Liu et al, 2016 ; Belcheva, 2017 ). The gut microbiota–miRNAs-diseases axis could serve as a new direction for future investigation.…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota: An Integral Moderator in Health and Disease

2018

View full text Add to dashboard Cite

The gut microbiota, as the main member in gut microecology, is an essential mediator in health and disease. The gut microbiota interacts with various organs and systems in the body, including brain, lung, liver, bone, cardiovascular system, and others. Microbiota-derived metabolites such as the short chain fatty acid (SCFA) butyrate are primary signals, which link the gut microbiota and physiology. Recently, the gut microbiota has been identified as the origin of a number of diseases by influencing the related cell signaling pathways such as WNT/beta-catenin pathway in colorectal cancer and T cell receptor signaling in the central nervous system. Moreover, several microRNAs participate in signaling networks through the intervention of the gut microbiota. The interaction between the gut microbiota and miRNAs plays a crucial role in vascular dysfunction and hepatocellular carcinoma (HCC). In this review, we will report and discuss recent findings about the crosstalk between the gut microbiota and physical organs and how the gut microbiota and miRNAs regulate each other while influencing the host via genes, proteins, or metabolites.

show abstract

MicroRNAs at the epicenter of intestinal homeostasis

Cited by 45 publications

References 118 publications

Modelling the structure of a ceRNA-theoretical, bipartite microRNA–mRNA interaction network regulating intestinal epithelial cellular pathways using R programming

Modelling the structure of a ceRNA-theoretical, bipartite microRNA–mRNA interaction network regulating intestinal epithelial cellular pathways using R programming

Anticancer potential of naturally occurring immunoepigenetic modulators: A promising avenue?

Gut Microbiota: An Integral Moderator in Health and Disease

Contact Info

Product

Resources

About