MicroRNAs Dysregulation as Potential Biomarkers for Early Diagnosis of Endometriosis

Ghasemi, Fahimeh; Alemzadeh, Effat; Allahqoli, Leila; Alemzadeh, Esmat; Mazidimoradi, Afrooz; Salehiniya, Hamid; Alkatout, İbrahim

doi:10.3390/biomedicines10102558

Cited by 7 publications

(3 citation statements)

References 83 publications

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“…Involved in almost all diseases, they have also been investigated in the pathophysiology of endometriosis [ 2 , 4 , 5 , 7 , 47 ]. Some miRNAs regulate the epithelial-mesenchymal transition [ 48 ], essential for the dissemination of epithelial cells. Others would modulate the hormonal environment (miRNAs -23a and -23b, miRNAs -:135a, 135b, 29c, and 194 −3p) via their interaction with SF1.…”

Section: Theories On Endometriosismentioning

confidence: 99%

Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement

2023

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Endometriosis is a chronic disease caused by ectopic endometrial tissue. Endometriotic implants induce inflammation, leading to chronic pain and impaired fertility. Characterized by their dependence on estradiol (via estrogen receptor β (ESRβ)) and their resistance to progesterone, endometriotic implants produce their own source of estradiol through active aromatase. Steroidogenic factor-1 (SF1) is a key transcription factor that promotes aromatase synthesis. The expression of SF1 and ESRβ is enhanced by the demethylation of their promoter in progenitor cells of the female reproductive system. High local concentrations of estrogen are involved in the chronic inflammatory environment favoring the implantation and development of endometriotic implants. Similar local conditions can promote, directly and indirectly, the appearance and development of genital cancer. Recently, certain components of the microbiota have been identified as potentially promoting a high level of estrogen in the blood. Many environmental factors are also suspected of increasing the estrogen concentration, especially prenatal exposure to estrogen-like endocrine disruptors such as DES and bisphenol A. Phthalates are also suspected of promoting endometriosis but throughmeans other than binding to estradiol receptors. The impact of dioxin or tobacco seems to be more controversial.

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Section: Theories On Endometriosismentioning

confidence: 99%

Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement

2023

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“…This ncRNA has the potential to be a diagnostic biomarker for the EMS. However, no specific miRNA has been transmitted from the laboratory to the clinic for diagnostic purposes in EMS ( 18 , 62 ). Although being a diagnostic biomarker has been studied more, miRNAs can control the progression of the disease by affecting various determining mechanisms.…”

Section: Non-coding Rnas Have Roles In the Inflammation And Immunopat...mentioning

confidence: 99%

The landscape of non-coding RNAs in the immunopathogenesis of Endometriosis

Abbaszadeh,

Karimi,

Rajaei

2023

Front. Immunol.

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Endometriosis is a complex disorder that is characterized by the abnormal growth of endometrial-like tissue outside the uterus. It is associated with chronic inflammation, severe pelvic pain, infertility, and significantly reduced quality of life. Although the exact mechanism of endometriosis remains unknown, inflammation and altered immunity are considered key factors in the immunopathogenesis of the disorder. Disturbances of immune responses result in reduced clearance of regurgitated endometrial cells, which elicits oxidative stress and progression of inflammation. Proinflammatory mediators could affect immune cells’ recruitment, fate, and function. Reciprocally, the activation of immune cells can promote inflammation. Aberrant expression of non-coding RNA (ncRNA) in patient and animal lesions could be suggestive of their role in endometriosis establishment. The engagement of these RNAs in regulating diverse biological processes, including inflammatory responses and activation of inflammasomes, altered immunity, cell proliferation, migration, invasion, and angiogenesis are widespread and far-reaching. Therefore, ncRNAs can be identified as a determining candidate regulating the inflammatory responses and immune system. This review aims in addition to predict the role of ncRNAs in the immunopathogenesis of endometriosis through regulating inflammation and altered immunity based on previous studies, it presents a comprehensive view of inflammation role in the pathogenesis of endometriosis.

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“…A recent study suggests that four miRNAs could be included as a prognostic marker in endometriosis 7 . However, future clinical studies should evaluate the efficacy of these miRNAs in endometriosis diagnosis and treatment 8 .…”

Section: Introductionmentioning

confidence: 99%

Genetic variants in miR-146a and miR-196a2 in endometriosis: a Brazilian study

Oliveira,

Cintra,

Lima

et al. 2024

Rev. Assoc. Med. Bras.

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OBJECTIVE:The aim of this study was to determine the allelic and genotypic frequencies of the polymorphisms, rs2910164 miR-146a and rs11614913 miR-196a2, by investigating their association with endometriosis. METHODS: This is a case-control study performed with approximately 120 women. The polymorphisms were determined by real-time polymerase chain reaction. For the statistical analysis, the chi-square and logistic regression tests were used. RESULTS: There were no significant differences in the genotype and allele frequencies of rs2910164 and rs11614913 between cases and controls. The frequencies in both polymorphisms are in accordance with Hardy-Weinberg equilibrium regarding miR-146a (patients: χ 2 =1.64, p=0.20; controls: χ 2 =0.25, p=0.62) and miR-196a2 (patients: χ 2 =0.58, p=0.44; controls: χ 2 =2.78, p=0.10). No relationship was observed between rs2910164 and rs11614913 and endometriosis in the inheritance models analyzed. CONCLUSION: In this study, our results show that the studied polymorphisms are not implicated in the development of endometriosis.

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MicroRNAs Dysregulation as Potential Biomarkers for Early Diagnosis of Endometriosis

Cited by 7 publications

References 83 publications

Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement

Endometriosis: Update of Pathophysiology, (Epi) Genetic and Environmental Involvement

The landscape of non-coding RNAs in the immunopathogenesis of Endometriosis

Genetic variants in miR-146a and miR-196a2 in endometriosis: a Brazilian study

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