microRNAs: Implications for air pollution research

Jardim, Melanie J.

doi:10.1016/j.mrfmmm.2011.03.014

Cited by 59 publications

(41 citation statements)

References 82 publications

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“…6,90 A growing list of studies illustrates the role of epigenetic mechanisms as links between these exposures and biological function and health. [91][92][93][94][95][96][97] For example, studies have found that higher concentrations of several persistent organic pollutants (POPs) are associated with a decrease in global methylation in humans, 98,99 while exposure to urban pollution has been shown to modify epigenetic markers and related regulatory enzymes in mice. 4,100 Exposure to heavy metals, such as arsenic, also alters methylation patterns, possibly due to competition for methyl donors since these metals become methylated during the metabolic process of detoxification.…”

Section: Environmental Toxicantsmentioning

confidence: 99%

Biological memories of past environments: Epigenetic pathways to health disparities

2011

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Section: Environmental Toxicantsmentioning

confidence: 99%

Biological memories of past environments: Epigenetic pathways to health disparities

2011

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“…Exposure to environmental neurotoxicants during pregnancy or early life, which are known to increase PD risk, may progressively damage SN and increase vulnerability to other environmental insults (TWO HIT model) [199]. Pollutant exposure might change expression profiles of microRNAs which are crucial mediators of post translational gene regulation [200].…”

Section: Gene-environment Interaction and Epigenetic Vulnerabilitymentioning

confidence: 99%

Disruption of Neurosynaptic Physiology and Neuron Network Dysfunction in Brain Disorders: An Environmental and Occupational Health Perspective

Pandey¹

2017

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Networks of signaling cascades regulate synaptic transmission and morphology. Signaling molecules and their dynamics are subject to impact of environmental insults as well as genes predisposing to disease risks. Pollutants may impact brain through cellular, molecular and inflammatory pathways, causing direct damage or predisposing to damage by other insults, leading to diseases. Disruptions in structure and function of neurotransmission elements and protein networks contribute to pathogenesis of neuropsychiatric diseases. Different affected brain regions and/or synaptic connections between excitatory and inhibitory neurons charecterise specific clinical states. Functional identification of synaptic signaling networks and specific neuronal pathways would facilitate understanding of specific pathomechanisms relevant to preventive and corrective interventions. Physiology of neural networks and pathogenesis, therapeutics and prevention of diseases arising of their disruption, specially with environmental afflictions, deserve holistic and not fragmentary understanding. Present article attempts to present such diverse information with possible coherence to emphasize necessary address in contemporary medical teaching and continuing education for young researchers. The mounting challenge of prevention and management of pollution inflicted disruption of neurophysiology associated with brain dysfunction and diseases in contemporary world may be better addressed by integrated interdisciplinary understanding of the problems.

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“…Over 1,000 miRNAs have been discovered, and they regulate nearly two-thirds of human genes [48]. Because miRNAs control numerous cellular processes, they may be critical for mediating biological responses to air pollutants [17]. To this end, a few studies have begun investigating the effects of air pollution exposure on selected miRNAs of interest.…”

Section: Air Pollutants and Mirnasmentioning

confidence: 99%

“…We focus primarily on epidemiologic studies in the past three years, as several good reviews exist summarizing the scientific evidence prior to 2010 (Table 1) [14][15][16][17]. We include discussion of supporting experimental data when appropriate, although an exhaustive review of experimental data is beyond the scope of this review.…”

Section: Introductionmentioning

confidence: 99%