MicroRNAs in biofluids are novel tools for bladder cancer screening

Liu, Xiaobing; Liu, Xin; Wu, Yuqi; Wu, Qingzhong; Wang, Qingqing; Yang, Zhenxing; Li, Longkun

doi:10.18632/oncotarget.16026

Cited by 43 publications

(32 citation statements)

References 104 publications

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“…The development of suitable biomarkers is vital for diagnosing cancer or predicting patient prognoses. miRNAs have attracted a great deal of attention as they are highly stable and may be a potential biomarker for tumors and other diseases (22,23). The prognostic and diagnostic value of miRNA expression in OS has been studied intensely in recent years (24,25).…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of microRNAs and their targets expressed in osteosarcoma

et al. 2019

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Osteosarcoma (OS) is the most common type of bone cancer in children and adolescents, and has a poor prognosis. Previous studies have demonstrated that a number of microRNAs (miRNAs) were deregulated in OS, and that the expression of certain miRNAs was correlated with the stage of OS. Therefore, miRNAs may serve a role as a diagnostic and prognostic biomarker of OS. miRNA and mRNA integrated analysis of public expression profiles in the Gene Expression Omnibus database for OS was performed, and the regulated targets of miRNA in OS were predicted. Next, the regulatory network of miRNAs/genes was constructed and verified by reverse transcription-quantitative polymerase chain reaction in tissues and MG-63 cell lines. Two miRNA expression profiling studies and four eligible mRNA expression profiling studies were selected. Ten upregulated miRNAs, 5 downregulated miRNAs and 5 DGEs were identified in OS compared with normal tissues. hsa-miR-346 was inversely correlated with the target gene c-FLIP, which was consistent with the results of integrated analysis. In vitro, pre-miRNA-346 can downregulate the protein expression of c-FLIP, while not changing the mRNA level of c-FLIP. In the regulatory network, hsa-miR-346 and its target gene, c-FLIP, can be used as biomarkers for an earlier diagnosis of OS.

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Section: Discussionmentioning

confidence: 99%

Identification and validation of microRNAs and their targets expressed in osteosarcoma

et al. 2019

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“…However, its expression increasement is associated with bladder cancer invasive state (X. Liu et al, 2017). Thus, it can be used as a (a) (b) (c) F I G U R E 2 miR-9 functions in human lung, gastric, and bladder cancer.…”

Section: Mir-9 In Bladder Cancermentioning

confidence: 99%

miR‐9: From function to therapeutic potential in cancer

Khafaei

Rezaie

Mohammadi

et al. 2019

Journal Cellular Physiology

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Malignant neoplasms are regarded as the main cause of death around the world; hence, many research studies were conducted to further perceive molecular mechanisms, treatment, and cancer prognosis. Cancer is known as a major factor for health‐related problems in the world. The main challenges associated with these diseases are prompt diagnosis, disease remission classification and treatment status forecast. Therefore, progressing in such areas by developing new and optimized methods with the help of minimally invasive biological markers such as circular microRNAs (miRNAs) can be considered important. miRNA interactions with target genes have specified their role in development, apoptosis, differentiation, and proliferation and also, confirm direct miRNA function in cancer. Different miRNAs expression levels in various types of malignant neoplasms have been observed to be associated with prognosis of various carcinomas. miR‐9 seems to implement opposite practices in different tissues or under various cancer incidences by influencing different genes. Aberrant miR‐9 levels have been observed in many cancer types. Therefore, we intended to investigate the precise role of miR‐9 in patients with malignant neoplasms. To this end, in this study, we attempted to examine different studies to clarify the overall role of miR‐9 as a prognostic marker in several human tumors. The presented data in this study can help us to find the novel therapeutic avenues for treatment of human cancers.

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“…EVs participate in cell–cell communication and can typically be classified based on their size (from 4 to 10 microns), intracellular origin, and density (Cocucci and Meldolesi, 2011; Raposo and Stoorvogel, 2013; Valadi et al ., 2007). EVs can be found in all different body fluids, such as blood, serum, plasma, saliva, urine, and pleural effusions (Fernandez‐Mercado et al ., 2015; Liu et al ., 2017a; Mitchell et al ., 2008; Ortiz‐Quintero, 2016; Weber et al ., 2010). In the last decade, several studies have shown that EVs are enriched for various proteins, such as cytokines, messenger RNAs, lipids, and noncoding RNAs, such as miRNAs and long noncoding RNAs (lncRNAs) (Colombo et al ., 2013; Valadi et al ., 2007).…”

Section: Introductionmentioning

confidence: 99%

Cell‐to‐cell communication: microRNAs as hormones

2017

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Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell‐to‐cell communication within the tumor microenvironment. EVs’ components, such as proteins, noncoding RNAs [microRNAs (miRNAs), and long noncoding RNAs (lncRNAs)], messenger RNAs (mRNAs), DNA, and lipids, can mediate paracrine signaling in the tumor microenvironment. Recently, miRNAs encapsulated in secreted EVs have been identified in the extracellular space. Mature miRNAs that participate in intercellular communication are released from most cells, often within EVs, and disseminate through the extracellular fluid to reach remote target cells, including tumor cells, whose phenotypes they can influence by regulating mRNA and protein expression either as tumor suppressors or as oncogenes, depending on their targets. In this review, we discuss the roles of miRNAs in intercellular communication, the biological function of extracellular miRNAs, and their potential applications for diagnosis and therapeutics. We will give examples of miRNAs that behave as hormones.

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MicroRNAs in biofluids are novel tools for bladder cancer screening

Cited by 43 publications

References 104 publications

Identification and validation of microRNAs and their targets expressed in osteosarcoma

Identification and validation of microRNAs and their targets expressed in osteosarcoma

miR‐9: From function to therapeutic potential in cancer

Cell‐to‐cell communication: microRNAs as hormones

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