MicroRNAs in Cancer and Cardiovascular Disease

Ilieva, Mirolyuba; Panella, Riccardo; Uchida, Shizuka

doi:10.3390/cells11223551

Cited by 21 publications

(15 citation statements)

References 158 publications

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“…[1][2][3] Aberrant expression of miRNAs is highly correlated with the development and progression of various types of human malignancies, and the quantication of the miRNA expressing level is signicant in cancer detection, staging, progression, and response to therapies. 4,5 For instance, alterations in the miRNA-21 expression level have a signicant effect on carcinogenesis and can function as an oncogenic gene in gastric carcinoma, a devastating illness with far-reaching consequences for world health. 6,7 The precise identication and quantitative determination of miRNAs are crucial for the clinical diagnosis and treatment of disease.…”

Section: Introductionmentioning

confidence: 99%

A simple, sensitive and label-free method for miRNA analysis in gastric cancer via catalytic hairpin assembly assisted programming of split-G-quadruplexes

Ma¹,

Li²,

Tao³

2023

Anal. Methods

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Section: Introductionmentioning

confidence: 99%

A simple, sensitive and label-free method for miRNA analysis in gastric cancer via catalytic hairpin assembly assisted programming of split-G-quadruplexes

Ma¹,

Li²,

Tao³

2023

Anal. Methods

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“…As a class of small molecular RNA, MicroRNA has the length of approximately 20–25 nucleotides. Through binding to the 3′ non‐coding region of the target gene mRNA, microRNA can cause the inhibition or degradation of the target mRNA, leading to gene silencing, and thus participating in a series of vital processes containing tumor proliferation, invasion and migration 19 . A series of evidences have indicated that miRNAs are abnormally expressed in the development of osteosarcoma, providing strong evidence for understanding the pathogenesis of osteosarcoma and diagnosis of osteosarcoma 20,21 .…”

Section: Introductionmentioning

confidence: 99%

“…Through binding to the 3 0 noncoding region of the target gene mRNA, microRNA can cause the inhibition or degradation of the target mRNA, leading to gene silencing, and thus participating in a series of vital processes containing tumor proliferation, invasion and migration. 19 A series of evidences have indicated that miRNAs are abnormally expressed in the development of osteosarcoma, providing strong evidence for understanding the pathogenesis of osteosarcoma and diagnosis of osteosarcoma. 20,21 In addition, miRNAs may affect the development and progression of osteosarcoma by the regulation of signaling pathways including PI3K/ Akt, Notch, RAS/P21, MAPK, Wnt, and Jun/FOS signaling pathways.…”

mentioning

confidence: 99%

Circ_LRP6 facilitates osteosarcoma progression via the miR‐122‐5p/miR‐204‐5p/HMGB1 axis

Wang

Xing

Gao

et al. 2023

Environmental Toxicology

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Circ_LRP6 is participated in the occurrence and development of numerous tumors. Nevertheless, its roles and mechanism in osteosarcoma (OS) is unknown. This study aims to illustrate this point. With the use of qRT‐PCR, the level of circ_LRP6, miR‐122‐5p, miR‐204‐5p and HMGB1 was identified. To observe cell proliferation, migration and invasion, we adopted CCK‐8 and Transwell assays in the present study. Besides, to prove the existing interaction, bioinformatics analysis and dual luciferase reporting assays were employed. The influence of circ_LRP6 on osteosarcoma in vivo was evaluated by subcutaneous tumor formation model in nude mice. In osteosarcoma tissues, circ_LRP6 and HMGB1 are strongly denoted, whereas miR‐122‐5p and miR‐204‐5p are under‐expressed. Circ_LRP6 knockdown could significantly hinder the proliferation, migration and invasion of osteosarcoma cells. Circ_LRP6 hindered the proliferation of osteosarcoma in vivo. Bioinformatics predicted that miR‐122‐5p and miR‐204‐5p functioned as direct targets of circ_LRP6, and HMGB1 were possible target genes of miR‐122‐5p and miR‐204‐5p. The findings indicated that the low level of miR‐122‐5p and miR‐204‐5p and the overexpression of HMGB1 could partially restore and reduce the inhibitory impact of circ_LRP6 on the proliferation, migration and invasion of osteosarcoma cells. Circ_LRP6 affects osteosarcoma progression via the miR‐122‐5p/miR‐204‐5p/HMGB1 axis, and is shown to be a molecular biomarker.

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“…MicroRNAs (miRNAs) can play the role of oncogenes or cancer suppressor genes in various types of human cancer. [9][10][11] miR-455-3p was under-expressed in various tumors and can be involved in adjusting diverse biological processes, containing cell proliferation, apoptosis, migration, and drug resistance, as a tumor suppressor gene. [12][13][14][15] According to previous studies, miR-455-3p inhibited PCa cell growth through targeted regulation of eIF4E.…”

Section: Introductionmentioning

confidence: 99%

Circ_0082878 contributes to prostate cancer progression via the miR‐455‐3p/WTAP axis

Zhao,

Han,

et al. 2023

Environmental Toxicology

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Circ_0082878 has been found to be strongly expressed in prostate cancer (PCa). However, its roles and potential mechanism in PCa have not been investigated. This study aims to clarify it. RNase R digestion method was adopted for verifying the circular structure of circ_0082878. RT‐qPCR assay is aimed to detect the expressions of circ_0082878, miR‐455‐3p and WTAP in PCa tissues and cells. For identifying cell proliferation, migration and invasion abilities, CCK‐8 and transwell assay were used. To show the correlation between miR‐455‐3p and WTAP or circ_0082878, the luciferase reporter gene, RNA RIP and RNA pull‐down experiments were employed. We employed western blot to detect protein level of WTAP. In addition, the impact of circ_0082878 on PCa cells in vivo was also studied. It was found that circ_0082878 and WTAP were highly expressed in PCa tissues and cells, whereas miR‐455‐3p was lowly expressed. Inhibition of circ_0082878 restrained the growth of PCa in vitro and in vivo. Regarding mechanism, miR‐455‐3p was the target of circ_0082878, and WTAP was the target of miR‐455‐3p. Circ_0082878 could downregulate the level of miR‐455‐3p, and inhibiting of miR‐455‐3p expression could partially eliminate the inhibitory impact of low expression of circ_0082878 on the proliferation and migration of PCa cells. Additionally, over‐expression of miR‐455‐3p resulted in the reduced level of WTAP, and WTAP over‐expression counteracted the tumor suppressive impact of miR‐455‐3p in PCa cells. Moreover, the obtained findings indicated that circ_0082878 may exert tumor‐promoting activity in PCa via sponging miR‐455‐3p and then upregulating WTAP. This indicates that the circ_0082878/miR‐455‐3p/WTAP axis can probably become the possible therapeutic target for PCa.

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MicroRNAs in Cancer and Cardiovascular Disease

Cited by 21 publications

References 158 publications

A simple, sensitive and label-free method for miRNA analysis in gastric cancer via catalytic hairpin assembly assisted programming of split-G-quadruplexes

A simple, sensitive and label-free method for miRNA analysis in gastric cancer via catalytic hairpin assembly assisted programming of split-G-quadruplexes

Circ_LRP6 facilitates osteosarcoma progression via the miR‐122‐5p/miR‐204‐5p/HMGB1 axis

Circ_0082878 contributes to prostate cancer progression via the miR‐455‐3p/WTAP axis

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