MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis

Shirjang, Solmaz; Mansoori, Behzad; Asghari, Samira; Duijf, Pascal H.G.; Mohammadi, Ali; Gjerstorff, Morten F.; Baradaran, Behzad

doi:10.1016/j.freeradbiomed.2019.05.017

Cited by 146 publications

(104 citation statements)

References 231 publications

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“…The binding of miRNA to mRNA leads to mRNA degradation or translational repression, and thus miRNAs are negative regulators of gene expression . Through the post‐transcriptional regulation of gene expression, miRNAs are believed to regulate various biological processes, including proliferation, apoptosis, the cell cycle, and differentiation, that are involved in both physiological and pathological progress . Currently, accumulating evidence indicates that various miRNAs are dysregulated in cerebral ischaemia/reperfusion injury and can be potentially used as diagnostic and/or therapeutic targets .…”

Section: Introductionmentioning

confidence: 99%

“…9 Through the post-transcriptional regulation of gene expression, miRNAs are believed to regulate various biological processes, including proliferation, apoptosis, the cell cycle, and differentiation, that are involved in both physiological and pathological progress. [10][11][12] Currently, accumulating evidence indicates that various miRNAs are dysregulated in cerebral ischaemia/ reperfusion injury and can be potentially used as diagnostic and/or therapeutic targets. 13,14 Various studies demonstrated that targeting specific miRNAs can alleviate neuronal injury and recover neurological functions using in vitro and in vivo experimental models of cerebral ischaemia/reperfusion injury.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of microRNA‐148b‐3p alleviates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling

et al. 2020

Clin Exp Pharma Physio

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MicroRNAs (miRNAs) have emerged as crucial regulators of neuronal injury during cerebral ischaemia/reperfusion injury. Various miRNAs are dysregulated during this pathological process; however, the precise role of these miRNAs in regulating neuronal injury remains largely unknown. In the current study, we explored the potential function of microRNA‐148b‐3p (miR‐148b‐3p) in regulating neuronal injury induced by oxygen‐glucose deprivation/reoxygenation (OGD/R) in vitro, a cellular model for mimicking cerebral ischaemia/reperfusion injury. We found that miR‐148b‐3p expression was significantly decreased in neurons in response to OGD/R exposure. Importantly, miR‐148b‐3p overexpression decreased cell viability and exacerbated apoptosis and reactive oxygen species (ROS) production in OGD/R‐exposed neurons. By contrast, miR‐148b‐3p inhibition improved cell viability and decreased apoptosis and ROS production in OGD/R‐exposed neurons. Notably, Sestrin2, a cytoprotective gene, was identified as a miR‐148b‐3p target gene. miR‐148b‐3p inhibition markedly increased Sestrin2 expression as well as the activation of nuclear factor erythroid‐2‐related factor 2 (Nrf2) antioxidant signalling. Moreover, silencing of Sestrin2 or Nrf2 significantly reversed the miR‐148‐3p‐inhibition‐mediated protective effect in OGD/R‐injured neurons. Overall, these results demonstrate that miR‐148b‐3p inhibition protects neurons from OGD/R‐induced apoptosis and ROS production through reinforcing Nrf2 antioxidant signalling via upregulation of Sestrin2. Our study indicates that the miR‐148b‐3p/Sestrin2/Nrf2 axis plays an important role in regulating neuronal injury and may serve as a potential therapeutic target for providing neuroprotection during cerebral ischaemia/reperfusion injury.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of microRNA‐148b‐3p alleviates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling

et al. 2020

Clin Exp Pharma Physio

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“…The first miRNA, lin-4, was discovered in 1993, and its roles were revealed to be involved in the larval development programs of the nematode Caenorhabditis elegans (Bartel, 2004;Sharma, 2017). Subsequently, a number of miRNAs have been found, and their roles have been characterized (Ramakrishna and Muddashetty, 2019;Shirjang et al, 2019). MiRNAs in humans and mice have been well studied, while the studies of miRNAs in lower vertebrates, such as fish, are just beginning.…”

Section: Introductionmentioning

confidence: 99%

“…Author(s) agree that this article remain permanently open access under the terms of the Creative Commons Attribution License 4.0 International License can directly regulate multidrug resistance protein 4 (MRP4, ABCC4), and polymorphisms in the ABCC4 3'-UTR have no significant effect on miRNA regulation (Markova and Kroetz, 2014). It has been demonstrated that one miRNA usually has multiple target sites to target different genes in tissues to regulate different processes in vivo, and the miRNA can promote the degradation of the target mRNA or block its translation into protein, meanwhile one mRNA can also be targeted by multiple miRNAs (Sharma, 2017;Shirjang et al, 2019). In addition, long noncoding RNAs can also target miRNAs and regulate their expression (Shu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…MiRNAs are very important regulators of cellular mechanisms and physiological processes, such as cell cycle progression, cell division, apoptosis and necroptosis (Shirjang et al, 2019). To date, numbers of miRNAs have been discovered in different organisms, and diverse roles of these miRNAs have been described in physiological or pathological conditions .…”

Section: Introductionmentioning

confidence: 99%

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MiR-124 involvement of apoptosis, immunity and regulator of diseases

Sun¹,

Huang²,

Yu³

et al. 2020

Afr. J. Biotechnol.

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Most microRNAs (miRNAs) are noncoding, conserved RNA molecules in vertebrates, and their roles are similar and very important. MiRNAs usually have tissue-specific expression, and abnormal levels of miRNAs have been associated with diseases and have been used as disease biomarkers. MiRNAs are widely involved in biological processes by regulating target mRNAs. MiR-124 is one of the best studied miRNAs in organisms. By targeting different mRNAs, miR-124 plays important roles in the central nervous system, cellular infiltration, pathophysiological processes of cardiovascular diseases, inflammation, immunity and tolerance, etc. This review mainly focuses on tissue-specific or abnormal expression of miR-124 as a biomarker and on the ways miR-124 for the treatment of serious diseases such as cancers.

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Oncogenes

Pierotti

Frattini²,

Epistolio³

et al. 2022

Holland‐Frei Cancer Medicine

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Overview The initiation and the progression of human neoplastic disease is a multistep process involving the accumulation of genetic changes, characterized by the activation of oncogenes and the inactivation of tumor suppressor genes, in somatic cells. Oncogenes are altered versions of the proto‐oncogenes involved in the regulation of cell growth that are activated by mutation, chromosomal rearrangement, or gene amplification. In this article, at first we describe the methods that have been applied for the discovery and the identification of oncogenes. Then, we present the genetic mechanisms of proto‐oncogenes activation with several examples and the role played by oncogenes in the initiation and progression of various cancers. The identification of oncogene abnormalities has provided tools for the molecular diagnosis and monitoring of cancer. Most important, oncogenes represent potential targets for new types of cancer therapies that permit to kill cancer cells selectively while sparing normal cells. These therapies display an evident benefit for the treatment of several tumors; however, mainly due to the occurrence of secondary resistance mechanisms, they are not able to kill 100% of neoplastic cells. In the last part of the article, we review all the genes for which a targeted therapy has been developed.

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MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis

Cited by 146 publications

References 231 publications

Inhibition of microRNA‐148b‐3p alleviates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling

Inhibition of microRNA‐148b‐3p alleviates oxygen‐glucose deprivation/reoxygenation‐induced apoptosis and oxidative stress in HT22 hippocampal neuron via reinforcing Sestrin2/Nrf2 signalling

MiR-124 involvement of apoptosis, immunity and regulator of diseases

Oncogenes

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