2021
DOI: 10.1134/s0006297921070014
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MicroRNAs in Cancer: From Gene Expression Regulation to the Metastatic Niche Reprogramming

Abstract: By 2003, the Human Genome project had been completed; however, it turned out that 97% of genome sequences did not encode proteins. The explanation came later when it was found the untranslated DNA contain sequences for short microRNAs (miRNAs) and long noncoding RNAs that did not produce any mRNAs or tRNAs, but instead were involved in the regulation of gene expression. Initially identified in the cytoplasm, miRNAs have been found in all cell compartments, where their functions are not limited to the degradati… Show more

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Cited by 32 publications
(12 citation statements)
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“…The involvement of miRNAs in the progression of tumors has been widely investigated. miRNAs might affect the development of various malignancies through regulating the malignant phenotypes of tumor cells [ 29 ]. miR-148a has been reported to play a tumor suppressive role in several types of tumors.…”
Section: Discussionmentioning
confidence: 99%
“…The involvement of miRNAs in the progression of tumors has been widely investigated. miRNAs might affect the development of various malignancies through regulating the malignant phenotypes of tumor cells [ 29 ]. miR-148a has been reported to play a tumor suppressive role in several types of tumors.…”
Section: Discussionmentioning
confidence: 99%
“…Importantly, this effect was cell-type-specific and was related particularly to Schwann cells, since fibroblast-derived exosomes failed to exert any beneficial actions on axon growth [60]. The exosomes derived from Schwann cells were demonstrated to be packed with growth factors (NGF, BDNF), cytokines (IL-6, IL-8), and cytoskeletal proteins (actin and β3-tubulin) required for the axon growth-cone modulation, myelin-associated glycoprotein, which is in huge demand for axon remyelination, and microRNA being of a paramount importance [61].…”
Section: The Role Of Exosomes In Regeneration Of Peripheral Nervesmentioning
confidence: 99%
“…For almost 30 years since miRNAs were discovered, they have received widespread attention due to their potential role in a wide variety of physiological and pathological processes, including neurogenesis, neuronal maturation, embryogenesis, and regeneration of the nervous system among other complicated biological processes. MiRNAs can affect the phenotype of both the recipient and donor cells [2,61].…”
Section: The Role Of Mirnas In the Regeneration Of Peripheral Nervesmentioning
confidence: 99%
“…MiRNA expression is dysregulated in cancer patients and differs from miRNA expression in healthy individuals [36,37]. Using open-source miRNA software, we identified six miRNAs that potentially target with VEGF-C transcription, and miR-196-3p synthesis was mostly decreased with WISP-3 treatment (Figure 5A).…”
Section: Inhibition Of Mir-196a-3p Controls Wisp-3-promoted Vegf-c Synthesismentioning
confidence: 99%