microRNAs in chronic kidney disease

Zhao, Hui; Ma, Shixing; Shang, You-Quan; Zhang, Huanqiao; Wei, Su

doi:10.1016/j.cca.2019.01.008

Cited by 60 publications

(47 citation statements)

References 71 publications

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“…Functional studies have shown that microRNA dysregulation is causal in myriad diseases, with microRNAs acting as activators or suppressors, and insight into the roles of microRNAs in disease progression has made microRNAs attractive targets of therapeutic modalities [96][97][98][99]. Here, we only highlight microRNA-21, -205 and -153 that play pivotal roles in renal disorders.…”

Section: Micrornasmentioning

confidence: 98%

Redox signaling in aging kidney and opportunity for therapeutic intervention through natural products

Chen

et al. 2019

Free Radical Biology and Medicine

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Kidney diseases are serious public problems with high morbidity and mortality in the general population and heavily retard renal function with aging regardless of the cause. Although myriad strategies have been assigned to prevent or harness disease progression, unfortunately, thus far, there is a paucity of effective therapies partly due to an insufficient knowledge of underlying pathological mechanisms, indicating deeper studies are urgently needed. Additionally, natural products are increasingly recognized as an alternative source for disease intervention owing to the potent safety and efficacy, which might be exploited for novel drug discovery. In this review, we primarily expatiate the new advances on mediators that might be amenable to targeting aging kidney and kidney diseases, including nicotinamide adenine dinucleotide phosphate oxidase (NOX), transforming growth factor-β (TGF-β), renin-angiotensin system (RAS), nuclear factor-erythroid 2 related factor 2 (Nrf2), peroxisome proliferator-activated γ receptor (PPARγ), advanced glycation endproducts (AGEs) as well as microRNAs and vitagenes. Of note, we conclude by highlighting some natural products which have the potential to facilitate the development of novel treatment for patients with myriad renal diseases.

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Section: Micrornasmentioning

confidence: 98%

Redox signaling in aging kidney and opportunity for therapeutic intervention through natural products

Chen

et al. 2019

Free Radical Biology and Medicine

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“…MicroRNAs (miRNAs) are highly conserved short noncoding RNAs, 18-25 nucleotides in length, and are the major post-transcriptional regulators of gene expression [10]. Recently, more and more studies have implicated that miR-NAs occupy a vital position in pathophysiology of renal diseases [11,12]. Moreover, the effects of some miRNAs on DN pathophysiology have been identified, revealing that miRNAs are promising therapeutic targets in DN [13].…”

Section: Introductionmentioning

confidence: 99%

MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3

Wang

2020

Bioscience Reports

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Objective: Diabetic nephropathy (DN) is one of the most severe and frequent diabetic complications. MicroRNAs (miRNAs) have been reported to play a vital role in DN pathogenesis. The present study aimed to investigate the molecular mechanism of miR-770-5p in DN. Methods: Podocyte injury model was established by treating mouse podocytes with high glucose (HG, 33 mM) for 24 h. The levels of miR-770-5p and TIMP3 were examined in kidney tissues and podocytes using quantitative real-time PCR (qRT-PCR). Flow cytometry analysis was applied to detect apoptosis in podocytes. Western blot assay was used to measure the protein levels of B-cell lymphoma 2 (Bcl-2), Bcl-2 associated X (Bax) and tissue inhibitors of metalloproteinase 3 (TIMP3). Enzyme-linked immunosorbent assay (ELISA) was conducted to measure the levels of inflammatory factors. The interaction between miR-770-5p and TIMP3 was determined by MicroT-CDS and luciferase reporter assay. Results: MiR-770-5p was up-regulated and TIMP3 was down-regulated in DN kidney tissues and HG-stimulated podocytes. Depletion of miR-770-5p suppressed cell apoptosis and the release of pro-inflammatory factors in HG-treated podocytes. Additionally, TIMP3 was a target of miR-770-5p in HG-treated podocytes. TIMP3 inhibited cell apoptosis and inflammation in HG-treated podocytes. Moreover, TIMP3 knockdown alleviated the inhibitory effect of miR-770-5p silencing on podocyte apoptosis and inflammatory response. Conclusion: Knockdown of miR-770-5p suppressed podocyte apoptosis and inflammatory response by targeting TIMP3 in HG-treated podocytes, indicating that miR-770-5p may be a potential therapeutic target for DN therapy.

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“…Recently, various miRNAs have been used as biomarkers for the diagnosis of kidney diseases and have also been found to be associated with the severity of diseases. In particular, it has been shown that miRNAs can be used as biomarkers in lupus nephritis, focal segmental glomerulosclerosis, IgA nephropathy, and diabetic nephropathy 18 .…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between MicroRNAs And Congenital Kidney Anomalies

Yılmaz¹,

Gündüz²,

Kütük

et al. 2020

Dicle Tıp Dergisi

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Objective: The purpose of this study was to identify diagnostic microRNAs (miRNAs) associated with congenital kidney anomalies. Methods: Twenty-five healthy pregnant women who were found to have fetal kidney anomaly in the second trimester of their pregnancy at Department of Perinatology, were included in the study. Serum samples were taken from the pregnant women at the moment of diagnosis in the antenatal 20th gestational week, whereas serum samples were taken from the cord blood of babies during birth. There were 11 multicystic dysplastic kidney patients, 6 autosomal recessive polycystic kidney patients, and 8 unilateral hypoplastic kidney patients. Expression of specific miRNAs was monitored using specific primer assays in Real-Time PCR. The expression of the following miRNAs was quantified: miR-17, miR-192, miR-194, miR-204, miR-215, and miR-216. Results: mir-17 expression was significantly lower in children with congenital kidney anomalies than in the control group. ROC curve analysis showed that the area under the curve was 0.700 for miR-17 in the prediction of congenital kidney anomalies. Conclusions: In children with congenital kidney anomalies, miR-17 expression was significantly different than in the control group. Thus, this miRNA may be used in the antenatal early detection of these congenital kidney anomalies.

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microRNAs in chronic kidney disease

Cited by 60 publications

References 71 publications

Redox signaling in aging kidney and opportunity for therapeutic intervention through natural products

Redox signaling in aging kidney and opportunity for therapeutic intervention through natural products

MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3

The Relationship Between MicroRNAs And Congenital Kidney Anomalies

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