MicroRNAs in Drosophila Cancer Models

Sander, Moritz; Herranz, Héctor

doi:10.1007/978-3-030-23629-8_9

Cited by 8 publications

(8 citation statements)

References 162 publications

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“…miRNAs are short noncoding RNAs that control gene activity mainly through post-transcriptional mechanisms. Recently, they have been linked to almost all biological processes and diseases, particularly cancer (Peng & Croce, 2016;Sander & Herranz, 2019). Concerning glioma, the miR-200 family (which includes miR-200, miR-141, and miR-429) plays central roles in GB development, metastasis, therapeutic response, and prognosis (reviewed in Peng et al [2018]).…”

Section: Introductionmentioning

confidence: 99%

Insulin signaling mediates neurodegeneration in glioma

et al. 2021

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Cell to cell communication facilitates tissue development and physiology. Under pathological conditions, brain tumors disrupt glia-neuron communication signals that in consequence, promote tumor expansion at the expense of surrounding healthy tissue. The glioblastoma is one of the most aggressive and frequent primary brain tumors. This type of glioma expands and infiltrates into the brain, causing neuronal degeneration and neurological decay, among other symptoms. Here, we describe in a Drosophila model how glioblastoma cells produce ImpL2, an antagonist of the insulin pathway, which targets neighboring neurons and causes mitochondrial disruption as well as synapse loss, both early symptoms of neurodegeneration. Furthermore, glioblastoma progression requires insulin pathway attenuation in neurons. Restoration of neuronal insulin activity is sufficient to rescue synapse loss and to delay the premature death caused by glioma. Therefore, signals from glioblastoma to neuron emerge as a potential field of study to prevent neurodegeneration and to develop anti-tumoral strategies.

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Section: Introductionmentioning

confidence: 99%

Insulin signaling mediates neurodegeneration in glioma

et al. 2021

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“…The ability to regulate a single transcriptional target in opposite directions depending on tissue type and cell fate choice is critical for normal development. The miRNA bantam has previously been identified as tumorigenic in Drosophila cancer models (Sander and Herranz, 2019). Potential human counterparts of bantam have been identified, including mir-450b that contains close sequence similarity (Ibanez-Ventoso et al, 2008) and has been described as suppressing cancer cell proliferation and inducing protective differentiation (Sun et al, 2014;Zhao et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate

Ford

Zraly

Perez

et al. 2020

Developmental Biology

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“…The regulation of ImpL2 expression in GB cells seems to depend on microRNAs, at least in part. In cancer, micro-RNAs have emerged as general regulators key for tumoral progression, including GB (Sander and Herranz, 2019). Interestingly, miR-200 family (miR-8 in Drosophila) play a key role in human GB.…”

Section: Recent Publications Suggested An Active Communication Betweementioning

confidence: 99%

“…MicroRNAs (miRNAs) are short non-coding RNAs that control gene activity mainly through post-transcriptional mechanisms. They m have been related recently to almost all biological processes and diseases, particularly cancer (Peng and Croce, 2016;Sander and Herranz, 2019). Related to glioma, the miR-200 family (which includes miR-200, miR-141 and miR-429) plays central roles in GB development, metastasis, therapeutic response, and prognosis (reviewed by (Peng et al, 2018)).…”

Section: Introductionmentioning

confidence: 99%

Insulin signaling mediates neurodegeneration in glioma

Jarabo

Pablo

Herranz

et al. 2020

Preprint

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Cell to cell communication facilitates tissue development and physiology. Under pathological conditions, brain tumors disrupt glia-neuron communication signals in which in consequence, promotes tumor expansion at expenses of healthy tissue. The glioblastoma is the most aggressive and frequent brain tumor. This type of glioma expands and infiltrates in the brain, causing neuronal degeneration and neurological decay, among other symptoms. Here we describe how glioblastoma produce ImpL2, an antagonist of the insulin pathway, which is regulated by the microRNA miR-8. ImpL2 targets neighboring neurons and causes mitochondrial disruption as well as synapse loss, an early symptom of neurodegeneration. Furthermore, glioblastoma progression requires insulin pathway attenuation in neurons. Restoration of neuronal insulin activity is sufficient to rescue this synapse loss and delay the premature death caused by glioma. Therefore, signals from GB to neuron emerge as a potential field of study to prevent neurodegeneration and anti-tumoral strategies. A. (2006). Age-independent synaptogenesis by phosphoinositide 3 kinase.

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MicroRNAs in Drosophila Cancer Models

Cited by 8 publications

References 162 publications

Insulin signaling mediates neurodegeneration in glioma

Insulin signaling mediates neurodegeneration in glioma

The Drosophila MLR COMPASS-like complex regulates bantam miRNA expression differentially in the context of cell fate

Insulin signaling mediates neurodegeneration in glioma

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