MicroRNAs in drug addiction: Current status and future perspectives

Zhao, Yue; Qin, Feng; Han, Shuang; Li, Shu; Zhao, Ying; Wang, Hongbo; Tian, Jingwei; Cen, Xiaobo

doi:10.1016/j.pharmthera.2022.108215

Cited by 15 publications

(14 citation statements)

References 270 publications

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“…Stable epigenetic modifications in specific neuronal populations occur because of persistent adaptation and are proportional to the nature and long-lasting of the experience of addiction [12,19,20].…”

Section: Epigenetic Mechanisms and Targets In Drug Addictionmentioning

confidence: 99%

“…[14][15][16][17][18]. Stable epigenetic modifications in specific neuronal populations occur because of persistent adaptation and are proportional to the nature and long-lasting of the experience of addiction [12,19,20]; similarly, changes in the epigenetic signature occurs in nociception leading to analgesic tolerance and dependence [21][22][23]. Hence, in recent years, epigenetic signature has been investigated centrally and at the periphery, providing evidence of new molecular pathways and new diagnostic, prognostic and therapeutic perspectives for the treatment of addiction.…”

Section: Introductionmentioning

confidence: 99%

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Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport

Mazzeo

Meccariello

Guatteo

2023

IJMS

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Opioids are substances derived from opium (natural opioids). In its raw state, opium is a gummy latex extracted from Papaver somniferum. The use of opioids and their negative health consequences among people who use drugs have been studied. Today, opioids are still the most commonly used and effective analgesic treatments for severe pain, but their use and abuse causes detrimental side effects for health, including addiction, thus impacting the user’s quality of life and causing overdose. The mesocorticolimbic dopaminergic circuitry represents the brain circuit mediating both natural rewards and the rewarding aspects of nearly all drugs of abuse, including opioids. Hence, understanding how opioids affect the function of dopaminergic circuitry may be useful for better knowledge of the process and to develop effective therapeutic strategies in addiction. The aim of this review was to summarize the main features of opioids and opioid receptors and focus on the molecular and upcoming epigenetic mechanisms leading to opioid addiction. Since synthetic opioids can be effective for pain management, their ability to induce addiction in athletes, with the risk of incurring doping, is also discussed.

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Section: Epigenetic Mechanisms and Targets In Drug Addictionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport

Mazzeo

Meccariello

Guatteo

2023

IJMS

View full text Add to dashboard Cite

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“…A large number of ncRNAs have been implicated in the onset and progression of drug addiction [118]. Whether these ncRNAs can be used as diagnostic indicators and therapeutic targets for AUD are also worthy of further study.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder

Wang¹,

Liu²,

Xia³

et al. 2023

Int. J. Biol. Sci.

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Alcohol use disorder (AUD) is one of the most prevalent neuropsychological disorders worldwide, and its pathogenesis is convoluted and poorly understood. There is considerable evidence demonstrating significant associations between multiple heritable factors and the onset and progression of AUD. In recent years, a substantial body of research conducted by emerging biotechnologies has increasingly highlighted the crucial roles of noncoding RNAs (ncRNAs) in the pathophysiology of mental diseases. As in-depth understanding of ncRNAs and their mechanisms of action, they have emerged as prospective diagnostic indicators and preclinical therapeutic targets for a variety of psychiatric illness, including AUD. Of note, dysregulated expression of ncRNAs such as circRNAs, lncRNAs and miRNAs was routinely found in AUD individuals, and besides, exogenous regulation of partial ncRNAs has also been shown to be effective in ameliorating alcohol preference and excessive alcohol consumption. However, the exact molecular mechanism still remains elusive. Herein, we systematically summarized current knowledge regarding alterations in the expression of certain ncRNAs as well as their-mediated regulatory mechanisms in individuals with AUD. And finally, we detailedly reviewed the potential theranostics applications of gene therapy agents targeting ncRNAs in AUD mice. Overall, a deeper comprehension of functional roles and biological mechanisms of ncRNAs may make significant contributions to the accurate diagnosis and effective treatment of AUD.

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“…It is also apparent that the deregulation of miRNAs is directly associated with the onset and progression of multiple diseases and pathological conditions. Furthermore, recent reviews have determined that miRNAs have roles in newer avenues, including drug addiction [ 226 ], neonatal sepsis [ 227 ], and the alteration of synaptic plasticity in depression [ 228 , 229 ], illustrating that this class of ncRNAs displays versatile functions in several aspects of cellular development as well as in pathological conditions.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Revisiting the miR-200 Family: A Clan of Five Siblings with Essential Roles in Development and Disease

2022

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Over two decades of studies on small noncoding RNA molecules illustrate the significance of microRNAs (miRNAs/miRs) in controlling multiple physiological and pathological functions through post-transcriptional and spatiotemporal gene expression. Among the plethora of miRs that are essential during animal embryonic development, in this review, we elaborate the indispensable role of the miR-200 family (comprising miR-200a, -200b, 200c, -141, and -429) in governing the cellular functions associated with epithelial homeostasis, such as epithelial differentiation and neurogenesis. Additionally, in pathological contexts, miR-200 family members are primarily involved in tumor-suppressive roles, including the reversal of the cancer-associated epithelial–mesenchymal transition dedifferentiation process, and are dysregulated during organ fibrosis. Moreover, recent eminent studies have elucidated the crucial roles of miR-200s in the pathophysiology of multiple neurodegenerative diseases and tissue fibrosis. Lastly, we summarize the key studies that have recognized the potential use of miR-200 members as biomarkers for the diagnosis and prognosis of cancers, elaborating the application of these small biomolecules in aiding early cancer detection and intervention.

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MicroRNAs in drug addiction: Current status and future perspectives

Cited by 15 publications

References 270 publications

Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport

Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport

Functional roles, regulatory mechanisms and theranostics applications of ncRNAs in alcohol use disorder

Revisiting the miR-200 Family: A Clan of Five Siblings with Essential Roles in Development and Disease

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