2013
DOI: 10.1155/2013/650218
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MicroRNAs in Head and Neck Cancer

Abstract: microRNAs (miRs) are small noncoding single-stranded RNAs, about 19–25 nucleotides long. They have been shown to be capable of altering mRNA expression; thus some are oncogenic or tumour suppressive in nature and are regulated by cellular and epigenetic factors. The molecular pathogenic pathway of many cancers has been modified since the discovery of miRs. Head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer in the world, has recently been associated with infection by the human papilloma… Show more

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Cited by 51 publications
(53 citation statements)
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References 127 publications
(268 reference statements)
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“…1, D and E), further emphasizing the complex nature of interaction between an miRNA and its target gene. Moreover, miRNAs are known to either degrade their target mRNAs or inhibit translation (22).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…1, D and E), further emphasizing the complex nature of interaction between an miRNA and its target gene. Moreover, miRNAs are known to either degrade their target mRNAs or inhibit translation (22).…”
Section: Discussionmentioning
confidence: 99%
“…They are known to regulate the expression level of oncogenes and tumor suppressors (22), and they may also act as oncogenes and tumor suppressor genes. For example, overexpressed miRNAs (e.g.…”
mentioning
confidence: 99%
“…This included usage of different platforms to measure RNA , inter-tumor heterogeneity in RNA expression, variability in sample dissection, the limited size of most sample datasets, and cohort differences in head and neck cancer etiology etc. [1, 10, 19]. With time, platform-dependent differences in RNA measurement results have been greatly reduced, though those for miRNA still can occur [2022].…”
Section: Possible Explanation For Poor Results In Diagnosis Using Oscmentioning
confidence: 99%
“…Other miRNAs are reduced in spe- cific tumour types and appear to be tumour suppressors [12], [13]. Much effort has gone into describing a set of miRNAs that show consistent changes in levels, first with head and neck squamous cell carcinomas (HNSCCs) [14]- [16] and more recently with subsets of these cancers such as OSCC [17].…”
Section: Introductionmentioning
confidence: 99%