MicroRNAs in heart and circulation during physical exercise

Wang, Lijun; Lv, Yicheng; Li, Guoping; Xiao, Junjie

doi:10.1016/j.jshs.2018.09.008

Cited by 78 publications

(65 citation statements)

References 69 publications

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“…However, the precise cellular and molecular mechanism for beneficial effects of exercise remains unclear. Nevertheless, non-coding RNAs, and especially microRNAs (miRNAs, miRNAs), constitute a new regulatory component that may play a role in exercise-induced adaptations (Silva et al, 2017;Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Circulating microRNAs in Response to Exercise Training in Healthy Adults

Zhou

Shi

et al. 2020

Front. Genet.

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Circulating microRNAs (miRNAs, miRs) have great potential as cardiac biomarkers and they are also being explored for their roles in intercellular communication and gene expression regulation. The analysis of circulating miRNAs in response to exercise would provide a deeper understanding of the molecular response to physical activity and valuable information for clinical practice. Here, eight male college students were recruited to participate in cardiopulmonary exercise testing (CPET) and 1 h acute exercise training (AET). Blood samples were collected and serum miRNAs involved in angiogenesis, inflammation and enriched in muscle and/or cardiac tissues were analyzed before and after cardiopulmonary exercise and acute exercise. The miRNAs we detected were miR-1, miR-20a, miR-21, miR-126, miR-133a, miR-133b, miR-146, miR155, miR-208a, miR-208b, miR-210, miR-221, miR-222, miR-328, miR-378, miR-499, and miR-940. We found that serum miR-20a was decreased significantly after CPET and serum miR-21 was increased after AET. In addition, no robust correlation was identified between the changes of these miRNAs and makers of cardiac function and exercise capacity, which indicates a distinct adaptation of these miRNAs to exercise. Future studies are highly needed to define the potential use of these circulating miRNAs as useful biomarkers of exercise training, and disclose the biological function of circulating miRNAs as physiological mediators of exercise-induced cardiovascular adaptation.

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Section: Introductionmentioning

confidence: 99%

Circulating microRNAs in Response to Exercise Training in Healthy Adults

Zhou

Shi

et al. 2020

Front. Genet.

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“…miRNAs, a vital class of upstream regulatory factors of gene expression, negatively regulate gene expression at the post-transcriptional level by binding to the 3 UTR of target mRNAs. miRNAs are broadly involved in various biological processes including development, cell differentiation, and apoptosis in vivo and in vitro (Bartel, 2004;Ouellet et al, 2006;Wang et al, 2018). However, the regulatory miRNA of agrin has not been reported.…”

Section: Discussionmentioning

confidence: 99%

Agrin Influences Botulinum Neurotoxin A-Induced Nerve Sprouting via miR-144-agrin-MuSK Signaling

Pan

Liu

et al. 2020

Front. Cell Dev. Biol.

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Botulinum neurotoxin (BoNT) has become a powerful therapeutic tool, and is extensively used in aesthetic medicine and in the treatment of neurological disorders. However, its duration of effect is limited, mainly owing to nerve sprouting. Inhibition of nerve sprouting to prolong the effective duration of BoNT is therefore of great clinical interest. However, appropriate interventional strategies to accomplish this are currently unavailable. In this study, we determined the role of the neurogenic regulator agrin in BoNT type A (BoNT/A)-induced nerve sprouting in a rat model. We then determined whether agrin could be used as an interventional target for prolonging the duration of effect of BoNT/A, and made a preliminary study of the upstream and downstream regulatory mechanisms by which agrin could influence the effective duration of BoNT/A. Our results showed that agrin was involved in the regulation of BoNT/A-induced nerve sprouting, and blocking of agrin function with anti-agrin antibody temporarily could delay muscle strength recovery and prolong the duration of BoNT/A effect. Moreover, agrin influenced the duration of BoNT/A effect by regulating downstream myogenic muscle-specific receptor tyrosine kinase (MuSK), and was simultaneously regulated by upstream miR-144. In conclusion, agrin could regulate BoNT/A-induced nerve sprouting through miR-144-agrin-MuSK signaling; it influences the effective duration of BoNT/A, and could find clinical application as an interventional target for prolonging the effect of BoNT/A.

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“…Recent studies indicated that miRNAs with specific changes in the progression of heart valve disease play key role in the processes of disease progression, such as fibrosis, calcification, matrix degradation remodeling, and inflammation. In addition, some miRNAs could also regulate extracellular body through exosomes and participate in circulation in the exocrine [21][22][23]. Further studies revealed that these miR-NAs can be used as biomarkers for cardiovascular diseases for clinical diagnosis and personalized medicine.…”

Section: Mirnas In Cardiovascular Diseasesmentioning

confidence: 99%

Online Databases and Non-coding RNAs in Cardiovascular Diseases

Chen

Shi

Yao

et al. 2020

Advances in Experimental Medicine and Biology

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Cardiovascular disease is characterized by its highest morbidity and mortality. One of the main pathological basis of this disease is the dysregulation of gene expression. Non-coding RNA (ncRNA) is a kind of functional RNA, which is transcript from DNA but not translated into proteins. More and more studies have established the important roles of ncRNAs, including transcription, RNA maturation, translation, protein degradation, and their involvement in the pathogenesis of diseases such as cancer and cardiovascular diseases. This chapter will focus on the biological functions of ncRNAs and their advances in cardiovascular disease. With the development of sequencing and computer technology, more and more databases can be easily obtained on the internet. In another part of this chapter, we will summarize some commonly used noncoding RNA databases, which can be easily and quickly used for relevant research.

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MicroRNAs in heart and circulation during physical exercise

Cited by 78 publications

References 69 publications

Circulating microRNAs in Response to Exercise Training in Healthy Adults

Circulating microRNAs in Response to Exercise Training in Healthy Adults

Agrin Influences Botulinum Neurotoxin A-Induced Nerve Sprouting via miR-144-agrin-MuSK Signaling

Online Databases and Non-coding RNAs in Cardiovascular Diseases

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