MicroRNAs in Plasma and Cerebrospinal Fluid as Potential Markers for Alzheimer's Disease

Kiko, Takehiro; Nakagawa, Kiyotaka; Tsuduki, Tsuyoshi; Furukawa, Koichi; Arai, Hiroyuki; Miyazawa, Teruo

doi:10.3233/jad-130932

Cited by 228 publications

(180 citation statements)

References 49 publications

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“…miRNAs are already being used commercially as disease biomarkers in oncology [17]. There is evidence for the use miRNAs as biomarkers in a wide range of diseases including prostate cancer [36], cardiac disease [37], acute kidney injury [38], and Alzheimer's disease [39]. If we could identify miRNAs that could be used as biomarkers for PCOS, the diagnosis and treatment of PCOS would be revolutionized.…”

Section: Discussionmentioning

confidence: 99%

Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome

Roth

McCallie

Alvero

et al. 2014

J Assist Reprod Genet

159

127

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Purpose To determine if microRNAs are differentially expressed in the follicular fluid of women with PCOS compared to fertile oocyte donors and identify associated altered gene expression. Methods Women undergoing IVF who met Rotterdam criteria for PCOS or who were fertile oocyte donors were recruited from a private IVF center. Individual follicle fluid was collected at the time of oocyte retrieval. MicroRNA analysis was performed using microarray and validated using real-time PCR on additional samples. Potential gene targets were identified and their expression analyzed by real time PCR. Results Microarray profiling of human follicular fluid revealed expression of 235 miRNAs, 29 were differentially expressed between the groups. Using PCR validation, 5 miRNAs (32, 34c, 135a, 18b, and 9) showed significantly increased expression in the PCOS group. Pathway analysis revealed genes involved in insulin regulation and inflammation. Three potential target genes were found to have significantly decreased expression in the PCOS group (interleukin 8, synaptogamin 1, and insulin receptor substrate 2).Conclusions MicroRNAs are differentially expressed in the follicular fluid of women with PCOS when compared to fertile oocyte donors. There is also altered expression of potential target genes associated with the PCOS phenotype.

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Section: Discussionmentioning

confidence: 99%

Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome

Roth

McCallie

Alvero

et al. 2014

J Assist Reprod Genet

159

127

View full text Add to dashboard Cite

show abstract

“…Decreased levels of this miRNA correlate with high tau and low Aβ amyloid levels. A second study analysed a selected group of miRNA candidates and observed that miRNAs 34a, 125b and 146a levels were significantly lower in the CSF of AD patients when compared to control cases, while the levels of the miRNAs 29a and 29b were significantly higher [181]. In an independent study low levels of miRNA-146a were also detected in the CSF of AD patients [182].…”

Section: Micrornasmentioning

confidence: 96%

New Frontiers in Alzheimer's Disease Diagnosis

Llorens¹,

Nuhn²,

Peter³

et al. 2015

Alzheimer's Disease - Challenges for the Future

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“…However, recent research suggests that miRNAs play an important role in the molecular pathogenesis of both genetic and sporadic AD (Berezin et al, 2014). The expression profile of miRNAs in patients with AD is significantly altered compared to that in controls, and these alterations may play a direct role in regulating the expression of AD-related genes and its subsequent phenotypic manifestations (Kiko et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-139 modulates Alzheimer’s-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2

Tang

Bao

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Alzheimer's disease (AD) is a neurodegenerative disorder, and is the most common type of dementia in the elderly population. Growing evidence indicates that microRNAs (miRNAs) play a crucial role in neuroinflammation associated with AD progression. In this study, we analyzed the expression of microRNA-139 (miR-139) as well as the learning and memory function in AD. We observed that the miR-139 expression was significantly higher in the hippocampus of aged senescence accelerated mouse prone 8 (SAMP8) mice (2.92 ± 0.13) than in the control mice (1.49 ± 0.08). Likewise, the overexpression of miR-139 by means of hippocampal injection impaired the hippocampus-dependent learning and memory formation. In contrast, the downregulation of miR-139 in mice improved learning and memory function in the mice. The level of cannabinoid receptor type 2 (CB2), a potential target gene of miR-139, was inversely correlated with the miR-139 expression in primary hippocampal cells. Furthermore, we demonstrated that miR-139 inversely modulated the responses to proinflammatory stimuli. Together, our findings demonstrate that miR- 139 exerts a pathogenic effect in AD by modulating CB2-meditated neuroinflammatory processes.

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MicroRNAs in Plasma and Cerebrospinal Fluid as Potential Markers for Alzheimer's Disease

Cited by 228 publications

References 49 publications

Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome

Altered microRNA and gene expression in the follicular fluid of women with polycystic ovary syndrome

New Frontiers in Alzheimer's Disease Diagnosis

MicroRNA-139 modulates Alzheimer’s-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2

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