MicroRNAs in Psychological Stress Reactions and Their Use as Stress-Associated Biomarkers, Especially in Human Saliva

Wiegand, Conrad; Savelsbergh, Andreas; Heusser, Peter

doi:10.1159/000481126

Cited by 22 publications

(32 citation statements)

References 80 publications

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“…We investigated psychological parameters of subjective stress perception, physiological stress parameters such as HRV-parameters, biochemical stress parameters (salivary cortisol levels and salivary alpha-amylase activity) as well as epigenetic parameters such as salivary microRNAs (miRNAs). For further details on other aspects of this project, we would like to refer to our recent publications 8 , 9 .…”

Section: Methodsmentioning

confidence: 99%

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Binary symbolic dynamics analysis to detect stress-associated changes of nonstationary heart rate variability

Spellenberg

Heusser

Büssing

et al. 2020

Sci Rep

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Psychological stress may have harmful physiological effects and result in deteriorating health. Acute psychological stress acts also on cardiac autonomic regulation and may lead to nonstationarities in the interbeat interval series. We address the requirement of stationary RR interval series to calculate frequency domain parameters of heart rate variability (HRV) and use binary symbolic dynamics derived from RR interval differences to overcome this obstacle. 24 healthy subjects (12 female, 20–35 years) completed the following procedure: waiting period, Trier Social Stress Test to induce acute psychological stress, recovery period. An electrocardiogram was recorded throughout the procedure and HRV parameters were calculated for nine 5-min periods. Nonstationarities in RR interval series were present in all periods. During acute stress the average RR interval and SDNN decreased compared to rest before and after the stress test. Neither low frequency oscillations (LF), high frequency oscillations (HF) nor LF/HF could unambiguously reflect changes during acute stress in comparison to rest. Pattern categories derived from binary symbolic dynamics clearly identified acute stress and accompanying alterations of cardiac autonomic regulation. Methods based on RR interval differences like binary symbolic dynamics should be preferred to overcome issues related to nonstationarities.

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Section: Methodsmentioning

confidence: 99%

“…To cope with acute psychological stress, the organism initiates several physiological, biochemical and molecular processes that can be conflated as the psychological stress response 8 . Furthermore, epigenetic regulation and gene expression are also altered 9 .…”

Section: Introductionmentioning

confidence: 99%

Binary symbolic dynamics analysis to detect stress-associated changes of nonstationary heart rate variability

Spellenberg

Heusser

Büssing

et al. 2020

Sci Rep

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“…MicroRNAs (miRNAs), a kind of endogenous non-coding RNAs of 18-22 nucleotides in length, negatively regulate target genes expression at posttranscriptional level [1][2][3]. As either oncogenes or anti-oncogenes, they are found to play vital roles in a wide range of fundamental biological processes, such as proliferation [4,5], differentiation [6,7], apoptosis [8,9], cell cycle [10][11][12][13], metastasis [14][15][16], stress response [17][18][19], metabolic [20][21][22] and etc. Owing to its detectability and stability in tissues, marrow or blood, a growing number of studies suggests that miRNAs can serve as promising biomarkers for the prognosis of carcinomas [23].…”

Section: Introductionmentioning

confidence: 99%

MiR-24-3p and various cancers: From a meta-analysis view

Wang

Chen

Zhang

et al. 2020

Preprint

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Background: A growing number of researches suggests that microRNAs (miRNAs) as oncogene or tumor suppressor genes play a fundamental role in various kinds of cancers. Among them, miR-24-3p, as a star molecule, is widely studied. However, the prognostic value of miR-24-3p is unclear and controversial. We conducted this meta-analysis to evaluate the prognostic value of miR-24-3p in a variety of cancers by integrated existing articles from four databasesMethods: PubMed, Embase, Web of Science, and Cochrane Library (last update in March 2020) were searched for approach literature. Hazard ratios (HRs) and odds ratios (ORs) were used to evaluate the association between miR-24-3p expression levels and prognostic value or clinicopathological characteristics, respectively.Results: A total of 15 studies from 14 literature were finally qualified and concluded in the present meta-analysis. A significantly worse overall survival was observed in higher expression of miR-24-3p cancer group for OS(Overall survival) of log rank tests and cox multivariate regression by fixed effects model. Also, we found a significant correlation between elevated miR-24-3p levels to RFS (Recurrence-free survival) and DFS(Disease free survival). In addition, the pooled odds ratios (ORs) showed that evaluated miR-24-3p was also associated with the larger tumor size (≥5cm) and advanced TNM stage (Ⅲ and Ⅳ).Conclusion: Built on the above findings, elevated expression levels of miR-24-3p may serve as a promising biomarker used to predict the worse prognosis of cancer patients.

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“…Furthermore, the subjective perception of (psychological) stress is individual and depends on individual coping capacities 4 . It leads to several responsive processes on the physiological, cellular and molecular levels of the organism 5 . Some physiological reactions can be reliably elicited through standardized experimental social stress tests such as the “Trier Social Stress Test” (TSST) 6 and are generally accepted as biological markers for psychological stress.…”

Section: Introductionmentioning

confidence: 99%

Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study

Wiegand

Heusser

Cysarz

et al. 2018

Sci Rep

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Stress is an important co-factor for the genesis and maintenance of many diseases and is known to have an effect on gene expression via epigenetic regulation. MicroRNAs (miRNAs) appear to function as one of the key factors of this regulation. This is the first study to investigate the response of 11 stress-associated miRNAs in human saliva - as a non-invasive source - in an experimental condition of acute psychological stress, and also their correlation with established psychological (subjective stress perception), physiological (heart rate and heart rate variability) and biochemical stress parameters (salivary cortisol and alpha-amylase). 24 healthy participants between 20 and 35 years of age were investigated, using the Trier Social Stress Test (TSST) to induce acute psychological stress. Stress-associated changes were significant for miR-20b, -21 and 26b, and changes in miR-16 and -134 were close to significance, recommending further research on these miRNAs in the context of stress reactions. Significant correlations with alpha-amylase suggest their integration in sympathetic stress regulation processes. Additionally, our results demonstrate the TSST as a reliable tool for studying salivary miRNAs as non-invasive indicators of epigenetic processes in acute psychological stress reactions.

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MicroRNAs in Psychological Stress Reactions and Their Use as Stress-Associated Biomarkers, Especially in Human Saliva

Cited by 22 publications

References 80 publications

Binary symbolic dynamics analysis to detect stress-associated changes of nonstationary heart rate variability

Binary symbolic dynamics analysis to detect stress-associated changes of nonstationary heart rate variability

MiR-24-3p and various cancers: From a meta-analysis view

Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study

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