MicroRNAs in the diagnosis, prognosis and treatment of cancer

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate critical cell processes such as cell proliferation, apoptosis and differentiation by modulating gene expression. MiRNAs deregulation has been observed extensively in cancer. Elegant studies have demonstrated that miRNAs are involved in the initiation and progression of several malignancies. In this review we will address the role of miRNAs in the diagnosis and prognosis of cancer. The development of new drugs mimicking or blocking miRNAs will be discussed

MicroRNA-129-1 acts as tumour suppressor and induces cell cycle arrest of GBM cancer cells through targeting IGF2BP3 and MAPK1

“…Global alterations in miRNA expression have been illustrated in a large number of malignancies 18 34 35. Some studies have reported the downregulation of miR-129-1 expression in GBM tumors11 28 but its function remains unknown 36.…”