MicroRNAs in the epigenetic regulation of disease progression in Parkinson’s disease

Selvakumar, Sushmaa Chandralekha; Preethi, K. Auxzilia; Tusubira, Deusdedit; Sekar, Durairaj

doi:10.3389/fncel.2022.995997

Cited by 8 publications

(3 citation statements)

References 65 publications

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“…As epigenetic regulating factors, miRNAs mainly control the mRNA translation by binding to 3′untranslated regions of mRNAs ( Zhang et al, 2019 ). A lot of miRNAs have been shown to epigenetically regulate the gene expression of PD-associated genes and control the disease progression ( Selvakumar et al, 2022 ). A review study reported that more than 80 miRNAs were reported to be altered in different tissues of patients with PD, of which 15 miRNAs were upregulated or downregulated in the 3 tissue samples of brain, cerebrospinal fluid (CSF), and blood of patients with PD as well as in animal models with PD by RNA sequencing, microarray, and microRNA qPCR analysis from 34 reported screening studies.…”

Section: Histone Acetylation In Parkinson’s Diseasementioning

confidence: 99%

Epigenetic modification in Parkinson’s disease

Song

Chen

Huang

et al. 2023

Front. Cell Dev. Biol.

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Parkinson’s disease (PD) is a common neurodegenerative disorder caused by genetic, epigenetic, and environmental factors. Recent advance in genomics and epigenetics have revealed epigenetic mechanisms in PD. These epigenetic modifications include DNA methylation, post-translational histone modifications, chromatin remodeling, and RNA-based mechanisms, which regulate cellular functions in almost all cells. Epigenetic alterations are involved in multiple aspects of neuronal development and neurodegeneration in PD. In this review, we discuss current understanding of the epigenetic mechanisms that regulate gene expression and neural degeneration and then highlight emerging epigenetic targets and diagnostic and therapeutic biomarkers for treating or preventing PD.

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Section: Histone Acetylation In Parkinson’s Diseasementioning

confidence: 99%

Epigenetic modification in Parkinson’s disease

Song

Chen

Huang

et al. 2023

Front. Cell Dev. Biol.

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“…Both lncRNA and miRNA control gene expression post-transcriptionally through either translational repression or mRNA degradation [ 73 ]. An excellent review has recently been published that highlights multiple aspects of the regulatory and diagnostic roles of miRNAs in PD: these are signaling mechanisms and epigenetic regulation; inflammation, ferroptosis, mitophagy and autophagy mediating pathways and miRNAs as biomarkers and therapeutic targets [ 74 ].…”

Section: Familial and Sporadic Forms Of Pd Epigenetic Aspectsmentioning

confidence: 99%

Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease

Dolgacheva

Зинченко

Гончаров

2022

IJMS

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An increasing number of the population all around the world suffer from age-associated neurodegenerative diseases including Parkinson’s disease (PD). This disorder presents different signs of genetic, epigenetic and environmental origin, and molecular, cellular and intracellular dysfunction. At the molecular level, α-synuclein (αSyn) was identified as the principal molecule constituting the Lewy bodies (LB). The gut microbiota participates in the pathogenesis of PD and may contribute to the loss of dopaminergic neurons through mitochondrial dysfunction. The most important pathogenetic link is an imbalance of Ca2+ ions, which is associated with redox imbalance in the cells and increased generation of reactive oxygen species (ROS). In this review, genetic, epigenetic and environmental factors that cause these disorders and their cause-and-effect relationships are considered. As a constituent of environmental factors, the example of organophosphates (OPs) is also reviewed. The role of endothelial damage in the pathogenesis of PD is discussed, and a ‘triple hit hypothesis’ is proposed as a modification of Braak’s dual hit one. In the absence of effective therapies for neurodegenerative diseases, more and more evidence is emerging about the positive impact of nutritional structure and healthy lifestyle on the state of blood vessels and the risk of developing these diseases.

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“…This contributes to their exceptional stability in the body. [16][17][18][19][20] So far, over 2000 miRNA molecules have been identified in the human body. A single circRNA molecule can simultaneously interact with multiple miRNA molecules, further emphasizing their complex regulatory functions.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of miRNA Expression in Patients with Gestational Diabetes Mellitus: Investigating Diagnostic Potential and Clinical Implications

Kunysz,

Cieśla,

Darmochwał-Kolarz

2024

DMSO

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Purpose Gestational diabetes mellitus (GDM) is common pregnancy complication (8%), characterized by hyperglycemia resulting from pathological homeostatic mechanisms. There’s a concerning trend of increasing GDM prevalence. New markers, particularly epigenetic ones, are sought for early detection and enhanced care. miRNA are small non-coding RNA molecules. The main goal was to investigate the potential role of miRNA (miR-16-5p, miR-222-3p, miR-21-5p) in GDM and their association with clinical features. Patients and Methods The study included 72 pregnant patients, with 42 having GDM and 30 in the control group. miRNA expression was measured using ELISA. Results There were no significant differences in miR-222-3p expression between GDM patients and the control group. The GDM group exhibited a positive correlation between miR-16-5p expression and miR-21-5p expression as well as between miR-16-5p expression and insulin resistance. In the GDM group, a positive correlation was observed between miR-21-5p expression and fasting glucose levels. Conclusion Results do not confirm the role of miR-222-3p in GDM pathogenesis or as a diagnostic marker. Additionally, a role for miR-16-5p in GDM pathogenesis was observed. Furthermore, a potential role for miR-21-5p in monitoring GDM treatment is indicated.

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MicroRNAs in the epigenetic regulation of disease progression in Parkinson’s disease

Cited by 8 publications

References 65 publications

Epigenetic modification in Parkinson’s disease

Epigenetic modification in Parkinson’s disease

Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease

Evaluation of miRNA Expression in Patients with Gestational Diabetes Mellitus: Investigating Diagnostic Potential and Clinical Implications

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