MicroRNAs involved with hepatocellular carcinoma (Review)

Mao, Bijing; Wang, Ge

doi:10.3892/or.2015.4275

Cited by 68 publications

(54 citation statements)

References 111 publications

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“…It has been reported in multiple studies that miRNAs are involved in the biology of many tumors, playing roles in cell proliferation, differentiation, motility, apoptosis, angiogenesis and metastasis [5-9]. In recent years, many miRNAs have been recognized to promote progression of HCC through enhancing oncogene expression or inhibiting tumor suppressor genes [10-12]. miRNA-873 has been reported to be frequently and aberrantly expressed in many cancers, such as glioblastoma [13], lung adenocarcinoma [14], breast cancer [15] and ovarian cancer [16].…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-873 Promotes Cell Proliferation, Migration, and Invasion by Directly Targeting TSLC1 in Hepatocellular Carcinoma

Han¹,

Zhang²,

Ni³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and has the third highest mortality rate among all cancers. MicroRNAs are a class of endogenous, single-stranded short noncoding RNAs. The purpose of this study was to study the role of microRNA-873 in HCC. Methods: The expression of miRNA-873 and tumor suppressor in lung cancer 1 (TSLC1) in HCC tissues and cell lines was detected by real-time quantitative RT-PCR (RT-qPCR) or western blot. A CCK-8 assay was used to examine cell proliferation; flow cytometry was used to assess the cell cycle; the Transwell migration assay was used to test for metastasis. Luciferase assays were performed to assess whether TSLC1 was a novel target of miRNA-873. Results: We showed that miRNA-873 was upregulated in HCC tissues and cell lines compared with the normal control. Knockdown of miRNA-873 inhibited the growth and metastasis of HepG2 and accelerated G1 phase arrest, while overexpression of miRNA-873 had the opposite effect. The dual-luciferase reporter assays revealed that TSLC1 was a novel target of miRNA-873. Further study showed that TSLC1 was decreased in HCC tissues and cell lines. There was a negative correlation between the expression levels of TSLC1 and miRNA-873. The effect of miRNA-873 overexpression was neutralized by TSLC1. We also found that miRNA-873 activated the PI3K/AKT/mTOR signaling pathway and promoted HCC. Conclusions: Our data demonstrated that miRNA-873 promoted HCC progression by targeting TSLC1 and provided a new target for the therapy of HCC.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-873 Promotes Cell Proliferation, Migration, and Invasion by Directly Targeting TSLC1 in Hepatocellular Carcinoma

Han¹,

Zhang²,

Ni³

et al. 2018

Cell Physiol Biochem

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“…lncRNAs acting as ceRNAs or natural miRNA sponges are important posttranscriptional regulators of gene expression, which communicate with and coregulate each other by competing for binding to shared miRNAs. Understanding this novel RNA crosstalk will shed light on gene regulatory networks and human development and disease (Afonso‐Grunz & Muller, ; Huarte, ; Mao & Wang, ; Mendell & Olson, ). Here, we showed that lncRNA NORAD overexpressed in HCC tissues, and elevated NORAD positively related to the poor prognosis and high recurrence rate of HCC patients.…”

Section: Discussionmentioning

confidence: 99%

The long noncoding RNA NORAD enhances the TGF‐β pathway to promote hepatocellular carcinoma progression by targeting miR‐202‐5p

Yang

Cai

Peng

et al. 2018

Journal Cellular Physiology

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Hepatocellular carcinoma (HCC) is one of the most fatal cancers with common features of invasion and metastasis. Recent evidence indicate that the long noncoding RNA NORAD is a potential oncogene and is significantly upregulated in several cancers. However, the general biological role and clinical value of NORAD in HCC remains unknown. Here, NORAD expression was measured in 29 paired tumor and paratumor tissues via quantitative real‐time polymerase chain reaction (qPCR). The effects of NORAD on HCC cell malignant potential were investigated via NORAD overexpression and knockdown both in vitro and in vivo. The mechanism of competitive endogenous RNAs (ceRNAs) was acquired and identified by bioinformatics analyses and luciferase assays. Moreover, the impact of NORAD level on the transforming growth factor β (TGF‐β) pathway was further determined by qPCR. We found that HCC tissues had a high level of NORAD compared with the paratumor tissues, and NORAD upregulation was associated with the shorter overall survival of patients with HCC. Furthermore, NORAD overexpression was demonstrated to promote HCC cell migration and invasion. Mechanically, NORAD might function as a ceRNA to regulate miR‐202‐5p, which served as a tumor‐suppressing microRNA via the TGF‐β pathway. We address that NORAD has a tumor‐promoting effect in HCC and describes a novel mechanism whereby NORAD regulates the TGF‐β pathway as a ceRNA of Homo sapiens (hsa)‐miR‐202‐5p.

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“…Generally, Taraxacum species are found effective against oxidative stress. Recently, it has been reported that T. marginellum was the most efficient extract reducing intracellular ROS levels although in vitro assays, T. obovatum was observed as the best free radical scavenger (Mingarro et al, 2015). Undoubtedly the above studies suggest the promising efficacy of TO against various drugs induced oxidative stress.…”

Section: Antioxidant Effectmentioning

confidence: 91%

“…These strategies are clearly implicated in anticancer efficacy of dandelion. In a very recent study it was found that relevant cytotoxic effect in T. lacistrum extract over HeLa and HepG2 cell lines (Mingarro et al, 2015). However, studies regarding the usefulness of TO against liver carcinoma experimental models are scanty or not available in literature.…”

Section: Anticancer Activitymentioning

confidence: 99%

“…HCC usually presents with poor outcomes due to the high rates of tumor recurrence and widespread metastasis (Mao and Wang, 2015). Recent results pointed out that natural products, in particular those present in Taraxacum root extract, have great potential as non-toxic and effective alternatives to conventional modes of chemotherapy available today (Ovadje et al, 2012).…”

Section: Anticancer Activitymentioning

confidence: 99%

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Hepatoprotective properties of Dandelion: recent update

Ezhilarasan¹

2016

J App Pharm Sci

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Taraxacum officinalis (Dandelion) have been used as folk medicines in China, India, and Russia for the treatment of chronic liver diseases. This review focuses exclusively on published literature pertaining to the potential use of Taraxacum officinalis or Dandelion for the treatment of various chronic liver diseases. Dandelion has been tested against various drugs and chemical induced chronic liver diseases in experimental animals and came out with promising results. In vitro studies also confirm the hepatoprotective, antioxidant and anti-inflammatory properties of dandelion. The extensive literature survey reveal the fact that Taraxacum officinalis or dandelion to be safe and the available evidence on the mechanisms of action appears promising, there are currently insufficient d ata from well-conducted clinical trials to recommend it use in patients with alcoholic liver chronic liver disease.

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MicroRNAs involved with hepatocellular carcinoma (Review)

Cited by 68 publications

References 111 publications

MicroRNA-873 Promotes Cell Proliferation, Migration, and Invasion by Directly Targeting TSLC1 in Hepatocellular Carcinoma

MicroRNA-873 Promotes Cell Proliferation, Migration, and Invasion by Directly Targeting TSLC1 in Hepatocellular Carcinoma

The long noncoding RNA NORAD enhances the TGF‐β pathway to promote hepatocellular carcinoma progression by targeting miR‐202‐5p

Hepatoprotective properties of Dandelion: recent update

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