MicroRNAs: potential biomarkers for diagnosis and prognosis of different cancers

Sharma, Prakash C.; Gupta, Alisha

doi:10.21037/tcr-20-1294

Cited by 48 publications

(23 citation statements)

References 218 publications

(330 reference statements)

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“…The outcomes of various researches have shown that many miRNAs have a positive value for gastric cancer in prognosis [ 22 , 36 ]. Recent progress in prognosis and treatment has considerably increased the long-term survival for patients with early gastric cancer [ 10 ]. For instance, downregulation of miR-451 was associated with worse prognosis of gastric cancer patients [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, in tumor cells, the dysregulation of microRNAs (abbreviated as miRNAs or miRs), as an abundant class of endogenous noncoding RNAs (about 18∼24 nt) suggests their tumorigenic or antitumorigenic effects on target genes expressed in the tumor environment [ 9 , 10 ]. Several miRNAs were showed to be related to the development and progression of gastric cancer, which also could predict the status of LNM before the surgical operation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Low Expression of miR-491-3p Is Correlated with Lymph Node Metastasis in Gastric Cancer

Luo

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. MiR-491-3p, as a tumor suppressor miRNA, was found decreased in many solid tissues. In this study, we aim to investigate miR-491-3p expression in gastric cancer with or without lymph node metastasis (LNM). Methods. GSE173215 dataset from Gene Expression Omnibus (GEO) was used to measure miRNA expression from tissue samples of gastric cancer patients. Moreover, gastric tumor tissues (non-LNM: n = 78; LNM: n = 68) were obtained to detect the miR-491-3p expression. Receiver operating characteristic (ROC) curve and Kaplan–Meier (KM) survival analysis, as well as Cox regression analysis, were performed to reveal the role of miR-491-3p in diagnosis and prognosis of gastric cancer. Results. According to GSE173215 datasets (t = −11.25, adjust P value = 1.30E-06) and our clinical results (0.390 ± 0.193 vs. 0.562 ± 0.166, P < 0.005 ), the gastric cancer patients with LNM showed lower miR-491-3p expression than those without LNM, demonstrating a high diagnostic efficiency (sensitivity: 74.36%; specificity: 69.12%). In addition, both LNM and low miR-491-3p expression were correlated with the poor prognosis of gastric cancer. Furthermore, the LNM patient with low expression of miR-491-3p had the worse prognosis, but the non-LNM patient with high expression of miR-491-3p had the best prognosis. MiR-491-3p expression (HR = 0.003, 95%CI: 3.35E-04∼0.028) and LNM (HR = 2.326, 95%CI: 1.046∼5.173) were independent risk factors for gastric cancer. Conclusion. Downregulated miR-491-3p expression was found in gastric cancer, being a high diagnostic efficiency and an independent risk factor for gastric cancer, especially in those having LNM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Low Expression of miR-491-3p Is Correlated with Lymph Node Metastasis in Gastric Cancer

Luo

2022

Evidence-Based Complementary and Alternative Medicine

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“…Examination of miRNAs for specific fractions can significantly increase both the sensitivity and specificity of selected circulating miRNAs as noninvasive biomarkers [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ].…”

Section: Circulating Mirnamentioning

confidence: 99%

miRNAs in Cancer (Review of Literature)

Smolarz

Durczyński

Romanowicz

et al. 2022

IJMS

136

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MicroRNAs (miRNAs) are short, noncoding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level by binding to mRNAs. miRNAs affect the course of processes of fundamental importance for the proper functioning of the organism. These processes include cell division, proliferation, differentiation, cell apoptosis and the formation of blood vessels. Altered expression of individual miRNAs has been shown in numerous cancers, which may indicate the oncogenic or suppressor potential of the molecules in question. This paper discusses the current knowledge about the possibility of using miRNA as a diagnostic marker and a potential target in modern anticancer therapies.

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“…miRNAs play important roles in several biological processes, including organ development, cell proliferation, apoptosis, and differentiation [ 7 , 8 , 9 , 10 ]. As their targets include oncogenes and/or tumor suppressor genes, miRNAs can function as tumor promoters or suppressors, and, due to their tissue- and disease-specific expression, they are often ideal candidates as tumor biomarkers [ 11 ]. Furthermore, miRNAs may confer specific features to tumors, including resistance to radiation and chemotherapy, cancer stem cell (CSC) maintenance as well as augmented angiogenesis [ 12 ], therefore constituting prognostic markers and/or therapeutic targets [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

2022

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The miR-29 family comprises miR-29a, miR-29b, and miR-29c, and these molecules play crucial and partially overlapped functions in solid tumors, in which the different isoforms are variously de-regulated and mainly correlated with tumor suppression. miR-29b is the most expressed family member in cancer, in which it is involved in regulating gene expression at both transcriptional and post-transcriptional levels. This review focuses on the role of miR-29b in breast cancer, in which it plays a controversial role as tumor suppressor or onco-miRNA. Here we have highlighted the dual effect of miR-29b on breast tumor features, which depend on the prevailing function of this miRNA, on the mature miR-29b evaluated, and on the breast tumor characteristics. Remarkably, the analyzed miR-29b form emerged as a crucial element in the results obtained by various research groups, as the most abundant miR-29b-3p and the less expressed miR-29b1-5p seem to play distinct roles in breast tumors with different phenotypes. Of particular interest are the data showing that miR-29b1-5p counteracts cell proliferation and migration and reduces stemness in breast tumor cells with a triple negative phenotype. Even if further studies are required to define exactly the role of each miR-29b, our review highlights its possible implication in phenotype-specific management of breast tumors.

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MicroRNAs: potential biomarkers for diagnosis and prognosis of different cancers

Cited by 48 publications

References 218 publications

Low Expression of miR-491-3p Is Correlated with Lymph Node Metastasis in Gastric Cancer

Low Expression of miR-491-3p Is Correlated with Lymph Node Metastasis in Gastric Cancer

miRNAs in Cancer (Review of Literature)

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

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