MicroRNAs: Potential Biomarkers of Disease Severity in Chronic Rhinosinusitis with Nasal Polyps

Abstract

Background and Objectives: Chronic rhinosinusitis with nasal polyps (CRwNP) has multiple clinical presentations, and predictors of successful treatment are correlated to different parameters. Differentially expressed microRNAs in nasal polyps emerge as possible facilitators of precise endotyping in this disease. We aimed to evaluate the correlation between the clinical parameters of CRSwNP and two different microRNAs. Materials and Methods: The expression of miR-125b and miR-203a-3p in nasal polyps (n = 86) and normal nasal mucosa (n = 20) was determined through microarray analysis. Preoperative workup included CT scan, nasal endoscopy, blood tests, symptoms and depression questionnaires. Results: MiR-125b showed significant overexpression in NP compared to the normal nasal mucosa. miR-125b expression levels were positively and significantly correlated with blood eosinophilia (p = 0.018) and nasal endoscopy score (p = 0.021). Although high CT scores were related to miR-125b overexpression, the correlation did not reach statistical significance. miR-203a-3p was underexpressed in nasal polyps and was significantly underexpressed in CRSwNP patients with environmental allergies. Conclusions: Both miR-125b and miR-203a-3p are potential biomarkers in CRSwNP. miR-125b also correlates with the clinical picture, while miR-203a-3p could help identify an associated allergy.

MicroRNA-125b Is a Potential Predictor of Surgical Outcomes in Chronic Rhinosinusitis with Nasal Polyps

“…17,18 Furthermore, in previous research on the matter, besides an overexpression in nasal polyps compared to the normal nasal mucosa, a correlation between miR-125b values and preoperative disease severity was proven. 19 The current study is the first to evaluate the potential role of miR-125 in predicting ESS outcomes for CRSwNP patients.…”

“…Multiple studies have already proven overexpression of miRNA-125b in CRSwNP patients. [16][17][18][19] It has been pointed to the role of miR-125b in innate immune activation, being linked to the airway antiviral innate immunity and mucosal eosinophilia. 17 Overexpression of miR-125b intensifies type I interferon expression, potentially contributing to increase in mucosal eosinophilia.…”

“…However, miR-125b is one of the most mentioned. [16][17][18][19] This study aimed to investigate whether the values of miR-125b are correlated with postoperative disease evolution in CRSwNP and whether this biomarker is a potential predictor of recurrence.…”

“Add What You Can to Life”

“…Gata and colleagues reported on 86 patients having first time sinus surgery for CRS with nasal polyps. 6 Multivariate analysis showed the greatest predictor for disease progression was miR-125b, even after adjusting for asthma, endoscopy score and CT score.…”