MicroRNAs Potentiate Neural Development

Fineberg, Sarah K.; Kosik, Kenneth S.; Davidson, Beverly L.

doi:10.1016/j.neuron.2009.10.020

Cited by 314 publications

(224 citation statements)

References 66 publications

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“…Several studies have suggested that microRNAs contribute to the establishment and maintenance of synaptic plasticity in developing and mature neurons (1,3,25,26). MicroRNAs regulated by neuronal activity are particularly suited for this role.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9

Chai

Cambronne

Eichhorn

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Significance Most brain regions comprise numerous neural cell types that are distinct in function and molecular characteristics. We examined microRNA-134 (miR-134) activity in cortical cultures using a microRNA sensor and discovered that miR-134 was induced in response to neuronal activity in somatostatin- and calretinin-expressing interneurons but not in pyramidal neurons. We identified the palmitoylation enzyme DHHC9 as a direct target of miR-134 and showed that it contributed to the regulation of H-Ras in somatostatin interneurons. H-Ras is a signaling molecule crucial for neuronal development and function. This study uncovered an activity-dependent miR-134 regulatory pathway in cortical interneurons that can potentially affect membrane localization of multiple signaling molecules.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9

Chai

Cambronne

Eichhorn

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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“…This leads to translational inhibition or mRNA degradation, reducing the production of hundreds of proteins (6). There is evidence indicating that miRNAs expressed in the brain are involved in neuronal development, survival and apoptosis (7). β-site amyloid precursor protein-cleaving enzyme1 (BACE1), a rate-limiting enzyme involved in the production of Aβ, is important in the pathogenesis of AD (8).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-29c targets β-site amyloid precursor protein-cleaving enzyme 1 and has a neuroprotective role in vitro and in vivo

Yang

Song

Zhou

et al. 2015

Molecular Medicine Reports

103

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Abstract. Alzheimer's disease (AD), characterized by β-amyloid deposition and neurodegeneration, is the most common cause of dementia worldwide. Emerging evidence suggests that ectopic expression of micro (mi)RNAs is involved in the pathogenesis of AD. There is increasing evidence that miRNAs expressed in the brain are involved in neuronal development, survival and apoptosis. The expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is regulated by dysregulated miRNAs in the brain. The present study determined the expression levels of the miRNA-29 (miR-29) family in peripheral blood samples of patients with AD and demonstrated a marked decrease in the expression of miR-29c compared with age-matched controls. In addition, a significant increase in the exprssion of BACE1 was observed in the peripheral blood of patients with AD. Correlation analysis revealed that the expression of miR-29c was negatively correlated with the protein expression of BACE1 in the peripheral blood samples from patients with AD. The present study also investigated the role of miR-29 on hippocampal neurons in vitro and in vivo. The results demonstrated that the upregulation of miR-29c promoted learning and memory behaviors in SAMP8 mice, at least partially, by increasing the activity of protein kinase A/cAMP response element-binding protein, involved in neuroprotection. This evidence suggested that miR-29c may be a promising potential therapeutic target against AD.

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“…42 Remarkably, miR-185 expression in the present study was particularly pronounced in these brain regions. As microRNAs play an important role in cortical and cerebellar development, 9 prominent miR-185 expression in the developing cortical plate and the cerebellum may be related to 22q11.2DS brain abnormalities. 38,39,42 Gene-based analysis of MIR185 and its predicted target genes revealed no individual or gene-wide association between schizophrenia and common variants at the MIR185 locus per se.…”

Section: Discussionmentioning

confidence: 99%

“…MicroRNAs are small noncoding RNAs that control the translation of target messenger RNAs (mRNAs). Accumulating evidence suggests that microRNAs contribute to the basic mechanisms underlying brain development and plasticity, 9,10 thus suggesting their possible involvement in the pathogenesis of several psychi atric disorders, 11 including schizophrenia. 12 This hypothesis is supported by a large genome-wide association study (GWAS) of schizophrenia conducted by the Psychi atric Genomics Consortium (PGC).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia

Forstner

Basmanav

Mattheisen³

et al. 2014

jpn

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Background: Schizophrenia is a complex neuropsychiatric disorder of unclear etiology. The strongest known genetic risk factor is the 22q11.2 microdeletion. Research has yet to confirm which genes within the deletion region are implicated in schizophrenia. The minimal 1.5 megabase deletion contains MIR185, which encodes microRNA 185. Methods: We determined miR-185 expression in embryonic and adult mouse brains. Common and rare variants at this locus were then investigated using a human genetics approach. First, we performed genebased analyses for MIR185 common variants and target genes using Psychiatric Genomics Consortium genomewide association data. Second, MIR185 was resequenced in German patients (n = 1000) and controls (n = 500). We followed up promising variants by genotyping an addi tional European sample (patients, n = 3598; controls, n = 4082). Results: In situ hybridization in mice revealed miR-185 expression in brain re gions implicated in schizophrenia. Genebased tests revealed association between common variants in 3 MIR185 target genes (ATAT1,

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MicroRNAs Potentiate Neural Development

Cited by 314 publications

References 66 publications

MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9

MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9

MicroRNA-29c targets β-site amyloid precursor protein-cleaving enzyme 1 and has a neuroprotective role in vitro and in vivo

Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia

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