MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases

Zhang, Guang-Qiong; Wang, Sheng-Quan; Chen, Yan; Fu, Lingyun; Xu, Yini; Li, Ling; Tao, Ling; Shen, Xiangchun

doi:10.3389/fphar.2021.663322

Cited by 24 publications

(19 citation statements)

References 150 publications

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“…Several miRNAs are specifically associated with the mitochondrial phenotype in human diseases (Zhang et al, 2021). Some of them, also known as mitomiRs, are produced by the mitochondrial genome to regulate the mRNA transcription in loco, others can target nuclear encoded mRNAs localized on the mitochondria surface, or are necessary for mitochondrial homeostasis (Latronico and Condorelli, 2012;Song et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease

Gambardella

Fiordelisi

Sorriento

et al. 2022

J Pharmacol Exp Ther

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We demonstrate for the first time that a specific signature of circulating mitochondrial microRNAs (mitomiRs) is dysregulated in Fabry disease (FD). In our study, we observed that mitomiRs regulating fundamental aspects of mitochondrial homeostasis and fitness, including expression and assembly of the respiratory chain, mitogenesis, antioxidant capacity, and apoptosis are significantly dysregulated in FD patients. Taken together, our new findings introduce mitomiRs as unprecedented biomarkers of FD and point at mitochondrial dysfunction as a novel potential mechanistic target for therapeutic approaches.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease

Gambardella

Fiordelisi

Sorriento

et al. 2022

J Pharmacol Exp Ther

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“…Placental microRNAs (miRNAs) are selectively packaged in the exosomes, secreted into the maternal and fetal circulation and transferred to target cells where they regulate gene expression [ 68 ]. Recent evidence suggests that miRNAs regulate GLUT1 expression as well as cardiac mitochondrial function [ 69 , 70 , 71 ]. Moreover, BPA alters the expression of several small RNAs in the mouse placentas [ 68 , 72 , 73 ].…”

Section: Discussionmentioning

confidence: 99%

Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model

Ermini

Mandalà

Cresti

et al. 2022

Cells

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Dietary exposure to Bisphenol A (BPA), an industrial chemical present in food containers, affects nutrient metabolism in the myocardium of offspring during intrauterine life. Using a murine model, we observed that fetal hearts from mothers exposed to BPA (2.5 μg/kg/day) for 20 days before mating and for all of the gestation had decreased expression of glucose transporter-1 (GLUT1), the principal sugar transporter in the fetal heart, and increased expression of fatty acid cluster of differentiation 36 transporter (CD36), compared to control fetuses from vehicle-treated mothers. We confirmed the suppression of GLUT1 by exposing fetal heart organotypic cultures to BPA (1nM) for 48 h but did not detect changes in CD36 compared to controls. During pregnancy, the placenta continuously releases extracellular vesicles such as exosomes into fetal circulation. These vesicles influence the growth and development of fetal organs. When fetal heart cultures were treated with cord blood-derived exosomes isolated from BPA-fed animals, GLUT1 expression was increased by approximately 40%. Based on our results, we speculate that exosomes from cord blood, in particular placenta-derived nanovesicles, could contribute to the stabilization of the fetal heart metabolism by ameliorating the harmful effects of BPA on GLUT1 expression.

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“…Various miRNAs have been described to contribute to distinct CVDs, such as HF, ischemic heart diseases, cardiac hypertrophy and diabetic cardiomyopathy, through the regulation of relevant signaling pathways and mitochondrial function-related proteins [ 49 ]. In this regard, several studies that used transgenic mice with overexpressed specific miRNA activity have demonstrated a crucial role in the initiation and progression of DCM through regulating genes involved in the maintenance of mitochondrial function ( Figure 1 and Table 1 ).…”

Section: Mitochondria Dysfunction and Mirnasmentioning

confidence: 99%

The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity

Alonso-Villa

Bonet

Hernández-Torres

et al. 2022

IJMS

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Dilated cardiomyopathy (DCM) is a clinical diagnosis characterized by left ventricular or biventricular dilation and systolic dysfunction. In most cases, DCM is progressive, leading to heart failure (HF) and death. This cardiomyopathy has been considered a common and final phenotype of several entities. DCM occurs when cellular pathways fail to maintain the pumping function. The etiology of this disease encompasses several factors, such as ischemia, infection, autoimmunity, drugs or genetic susceptibility. Although the prognosis has improved in the last few years due to red flag clinical follow-up, early familial diagnosis and ongoing optimization of treatment, due to its heterogeneity, there are no targeted therapies available for DCM based on each etiology. Therefore, a better understanding of the mechanisms underlying the pathophysiology of DCM will provide novel therapeutic strategies against this cardiac disease and their different triggers. MicroRNAs (miRNAs) are a group of small noncoding RNAs that play key roles in post-transcriptional gene silencing by targeting mRNAs for translational repression or, to a lesser extent, degradation. A growing number of studies have demonstrated critical functions of miRNAs in cardiovascular diseases (CVDs), including DCM, by regulating mechanisms that contribute to the progression of the disease. Herein, we summarize the role of miRNAs in inflammation, endoplasmic reticulum (ER) stress, oxidative stress, mitochondrial dysfunction, autophagy, cardiomyocyte apoptosis and fibrosis, exclusively in the context of DCM.

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MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases

Cited by 24 publications

References 150 publications

Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease

Mitochondrial microRNAs Are Dysregulated in Patients with Fabry Disease

Fetal Myocardial Expression of GLUT1: Roles of BPA Exposure and Cord Blood Exosomes in a Rat Model

The Role of MicroRNAs in Dilated Cardiomyopathy: New Insights for an Old Entity

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